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公开(公告)号：US10675356B2
公开(公告)日：2020-06-09
申请号：US15574734
申请日：2016-05-19
发明人： Gunnar J. Hanson , Ming Zhou
摘要： Provided herein are oligonucleotides, peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
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公开(公告)号：US10202602B2
公开(公告)日：2019-02-12
申请号：US15247584
申请日：2016-08-25
IPC分类号： C12N15/113 , C07F9/59 , C07F9/572 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C07H21/00 , A61K31/496 , A61K31/5377 , C07D265/30 , C07D295/108 , C07F9/22 , C07F9/26 , C07F9/6544
摘要： Oligonucleotide analogs comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
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公开(公告)号：US09790499B2
公开(公告)日：2017-10-17
申请号：US15007017
申请日：2016-01-26
发明人： Gunnar J. Hanson , Dwight D. Weller , Bao Zhong Cai , Ming Zhou
IPC分类号： C12N15/113 , C07H21/00 , C07F9/6558 , C07F9/6561 , C07F9/6584
CPC分类号： C12N15/113 , C07F9/65583 , C07F9/65586 , C07F9/65616 , C07F9/65846 , C07H21/00 , C12N15/1131 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/346 , C12N2310/351 , C12N2310/3513 , C12N2310/353
摘要： Functionally-modified oligonucleotide analogs comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
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