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61 条记录 (耗时 0.033 秒)

    Methods for oral decorporation of metals
    21.
    发明授权
    Methods for oral decorporation of metals 失效
    口服金属化学方法

    公开(公告)号：US5494935A

    公开(公告)日：1996-02-27

    申请号：US415361

    申请日：1995-04-03

    申请人： Scott C. Miller ,  Friedrich W. Bruenger

    发明人： Scott C. Miller ,  Friedrich W. Bruenger

    IPC分类号： A61K31/195 ,  A61K31/13

    CPC分类号： A61K31/195

    摘要： Several new powerful chelating agents, suitable for the removal of a variety of certain heavy metal ions from the body of a mammal by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyaminocarboxylic acids (PACA). They were synthesized in non-aqueous media from triethylenetetramine (TT) by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino groups using ethylbromoacetate and subsequent alkaline hydrolysis of the ester. In contrast to their non-lipophilic counterparts EDTA and DTPA, compositions of the present inventions exhibit appreciable absorption from the intestine and, therefore, can be administered orally. By varying the length of the alkyl chain, the chelons can be directed primarily to selected target organs. In addition, the compounds can be modified to target particular absorbed heavy metals.

    摘要翻译： 已经合成并测试了适用于通过口服应用从哺乳动物身体中除去多种某些重金属离子的几种新的强效螯合剂。 在结构上，这些化合物是部分亲脂性聚氨基羧酸（PACA）。 它们在非水介质中由三亚乙基四胺（TT）通过伯氨基的单烷基化合成，然后使用乙酸乙酯进行残留的氨基的残留羧甲基化，随后碱的水解。 与其非亲脂性对应物EDTA和DTPA相反，本发明的组合物表现出明显的肠吸收，因此可以口服给药。 通过改变烷基链的长度，可以将螯合剂主要导向选定的靶器官。 此外，化合物可以被修饰以靶向特定的吸收重金属。

    Method and apparatus for spectrum allocation in wireless networks
    23.
    发明授权
    Method and apparatus for spectrum allocation in wireless networks 有权
    无线网络中频谱分配的方法和装置

    公开(公告)号：US08958810B2

    公开(公告)日：2015-02-17

    申请号：US11557176

    申请日：2006-11-07

    申请人： Milind M. Buddhikot ,  Scott C. Miller ,  Kevin Ryan

    发明人： Milind M. Buddhikot ,  Scott C. Miller ,  Kevin Ryan

    IPC分类号： H04W72/00 ,  H04W16/10 ,  H04W16/14

    CPC分类号： H04W16/10 ,  H04W16/14 ,  H04W24/02 ,  H04W72/048

    摘要： The invention includes a method and apparatus for dynamically allocating spectrum available within a region including a plurality of base stations. The method includes obtaining a plurality of spectrum demands associated with at least a portion of the base stations, each spectrum demand requesting a portion of the available spectrum, and determining a plurality of spectrum allocations satisfying at least a portion of the spectrum demands. The spectrum allocations are determined by processing the spectrum demands using network information such as base station information associated with the base stations and region information such as terrain information associated with the region. The region information may include signal propagation information.

    摘要翻译： 本发明包括一种用于在包括多个基站的区域内动态分配可用频谱的方法和装置。 该方法包括获得与至少一部分基站相关联的多个频谱需求，每个频谱需求请求可用频谱的一部分，以及确定满足频谱需求的至少一部分的多个频谱分配。 通过使用诸如与基站相关联的基站信息的网络信息和诸如与该区域相关联的地形信息的区域信息来处理频谱需求来确定频谱分配。 区域信息可以包括信号传播信息。

    Azacycloalkanone serine protease inhibitors
    28.
    发明授权
    Azacycloalkanone serine protease inhibitors 有权
    氮杂环烷酮丝氨酸蛋白酶抑制剂

    公开(公告)号：US06469029B1

    公开(公告)日：2002-10-22

    申请号：US09661327

    申请日：2000-09-13

    申请人： Scott C. Miller ,  Juan José Marugán Sánchez ,  Kristin D. Haslow ,  Jonathan Hall

    发明人： Scott C. Miller ,  Juan José Marugán Sánchez ,  Kristin D. Haslow ,  Jonathan Hall

    IPC分类号： A61K31445

    CPC分类号： C07K5/06139 ,  A61K38/00

    摘要： The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having Formula I: or pharmaceutically acceptable salts thereof; wherein Q is phenyl, benzyl, pyridyl, thienyl, indolyl, quinolinyl, benzothienyl, biphenylyl, or imidazolyl; any of which can include one or more optional substituents independently selected from halo, trifluoromethyl, hydroxy, amino, nitro, cyano, C1-3 alkoxy, C1-3 alkyl, methylenedioxy, carboxamido, acetamido, or amidino; X is methylene, carbonyl, or sulfonyl; Z is methylene, ethylene, or propylene; M is methylene or ethylene; and R1 R2 and R3 are independently hydrogen or C1-3 alkyl.

    摘要翻译： 本发明涉及可用于治疗动脉和静脉血栓闭塞障碍，炎症，癌症和神经变性疾病的非肽因子Xa抑制剂。 因子Xa抑制剂提供具有式I化合物或其药学上可接受的盐; 其中Q是苯基，苄基，吡啶基，噻吩基，吲哚基，喹啉基，苯并噻吩基，联苯基或咪唑基; 其中任何一个可以包括一个或多个选自卤素，三氟甲基，羟基，氨基，硝基，氰基，C 1-3烷氧基，C 1-3烷基，亚甲二氧基，甲酰氨基，乙酰氨基或脒基的任选取代基; X是亚甲基，羰基， 或磺酰基; Z是亚甲基，亚乙基或亚丙基; M是亚甲基或亚乙基; 并且R 1和R 2独立地是氢或C 1-3烷基。

    System for individual and remote control of spaced lighting fixtures
    29.
    发明授权
    System for individual and remote control of spaced lighting fixtures 有权

    公开(公告)号：US06310440B1

    公开(公告)日：2001-10-30

    申请号：US09479744

    申请日：2000-01-07

    申请人： Adam T. Lansing ,  Russell L. MacAdam ,  Noel Mayo ,  Scott C. Miller ,  Robert A. Reiss ,  Ian Rowbottom ,  Joel S. Spira

    发明人： Adam T. Lansing ,  Russell L. MacAdam ,  Noel Mayo ,  Scott C. Miller ,  Robert A. Reiss ,  Ian Rowbottom ,  Joel S. Spira

    IPC分类号： G05F100

    CPC分类号： F21V23/0435 ,  G08C2201/71 ,  H05B37/02 ,  H05B37/0272 ,  H05B39/088 ,  H05B41/36 ,  H05B41/3922

    摘要： A plurality of spaced ceiling mounted fixtures or other controllable electrical appliances have radiation detectors mounted within each fixture and wired internally of the fixture to a dimming circuit or to a ballast. The radiation detectors have sensitivity over a wide angle and have elongated plastic radiation conduction rods which extend to or beyond the plane of the lens of the fixture to be located free of shadow effects of reflections of the fixture lens. A flexible end light fiber optics can be used in place of the acrylic rods. A narrow beam radiation transmitter selectively illuminates one of the rods or end light fiber optics without illuminating the others. The dimming circuits or ballasts within the fixtures can be further controlled by external dimmers, occupancy sensors, timeclocks, photosensors and other types of input devices. The radiation detector and ballast can occupy a common housing and share the same power supply and circuit board. The microcontroller for the radiation detector operates with a 4 of 4 voting mode until a valid signal is detected to switch the system to a 3 of 4 voting mode. A novel mounting adaptor for mounting a visible light fiber optic cable is disclosed with the visible light fiber optic cable conducting infrared radiation for up to 24 inches.