公开(公告)号：US10424394B2

公开(公告)日：2019-09-24

申请号：US13829373

申请日：2013-03-14

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula

IPC: G16B30/00 ,  C12Q1/6827 ,  G16B20/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US12112832B2

公开(公告)日：2024-10-08

申请号：US16573161

申请日：2019-09-17

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  Amin Mazloom

IPC: G16B20/10 ,  C12Q1/6869 ,  C12Q1/6883 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20 ,  G16B40/00

CPC classification number: G16B20/10 ,  C12Q1/6869 ,  C12Q1/6883 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20 ,  G16B40/00 ,  C12Q2545/101 ,  C12Q2545/114

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20220411871A1

公开(公告)日：2022-12-29

申请号：US17751201

申请日：2022-05-23

Applicant: Sequenom, Inc.

Inventor： Taylor Jacob Jensen ,  Jennifer Geis ,  Sung Kyun Kim ,  Cosmin Deciu ,  Mathias Ehrich

IPC: C12Q1/6883 ,  G16B25/00 ,  G16B45/00 ,  G16B25/10 ,  G16B25/20

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20220093207A1

公开(公告)日：2022-03-24

申请号：US17544537

申请日：2021-12-07

Applicant: Sequenom, Inc.

Inventor： Amin Mazloom ,  Cosmin Deciu ,  Chen Zhao ,  Tong Liu ,  Yijin Wu

IPC: G16B20/10 ,  G16B40/00 ,  G16B20/00 ,  G16B20/20 ,  G06N7/00

Abstract: Technology provided herein relates in part to non-invasive classification of one or more genetic copy number alterations (CNAs) for a test sample. Certain methods include sampling a quantification of sequence reads from parts of a genome, generating a confidence determination, and using the confidence determination to enhance classification. Technology provided herein is useful for classifying a genetic CNA for a sample as part of non-invasive pre-natal (NIPT) testing and oncology testing, for example.

公开(公告)号：US20210272650A1

公开(公告)日：2021-09-02

申请号：US17140426

申请日：2021-01-04

Applicant: Sequenom, Inc.

Inventor： Cosmin Deciu ,  Chen Zhao

IPC: G16B30/00 ,  C12Q1/6869

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of nucleic acid fragments from circulating cell free nucleic acid. Also provided herein are methods for partitioning one or more genomic regions of a reference genome into a plurality of portions according to one or more features.

公开(公告)号：US11004537B2

公开(公告)日：2021-05-11

申请号：US15647171

申请日：2017-07-11

Applicant: SEQUENOM, INC.

Inventor： Lin Tang ,  Cosmin Deciu

IPC: G16H20/00 ,  C12Q1/6869 ,  C12Q1/6874 ,  G16B30/00 ,  G16B40/00 ,  G16B20/00

Abstract: Provided in part herein are methods and processes that can be used for non-invasive assessment of a genetic variation which can lead to diagnosis of a particular medical condition or conditions. Such methods and processes can, for example, identify dissimilarities or similarities for one or more features between a subject data set and a reference data set, generate a multidimensional matrix, reduce the matrix into a representation and classify the representation into one or more groups. Methods and processes described herein are applicable to data in biotechnology and other fields.

公开(公告)号：US11001884B2

公开(公告)日：2021-05-11

申请号：US15647148

申请日：2017-07-11

Applicant: SEQUENOM, INC.

Inventor： Dirk Johannes Van Den Boom ,  Charles R. Cantor ,  Sung Kyun Kim ,  Zeljko Dzakula ,  Cosmin Deciu

IPC: C12Q1/6869 ,  G16B20/00 ,  C12Q1/6827 ,  G16B30/00 ,  G16B40/00

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20200168296A1

公开(公告)日：2020-05-28

申请号：US16664265

申请日：2019-10-25

Applicant: Sequenom, Inc.

Inventor： Cosmin Deciu ,  Zeljko Dzakula

IPC: G16B30/00 ,  G16B20/00 ,  G16B25/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US09920361B2

公开(公告)日：2018-03-20

申请号：US13782857

申请日：2013-03-01

Applicant: SEQUENOM, INC.

Inventor： Sung K. Kim ,  Cosmin Deciu

IPC: C12Q1/68 ,  G06F19/22 ,  G06F19/24

CPC classification number: C12Q1/6869 ,  G06F19/22 ,  G06F19/24

Abstract: Technology provided herein relates in part to methods, processes, compositions and apparatuses for analyzing nucleic acid.

公开(公告)号：US20160034640A1

公开(公告)日：2016-02-04

申请号：US14812432

申请日：2015-07-29

Applicant: Sequenom, Inc.

Inventor： Chen ZHAO ,  Cosmin Deciu ,  Dirk Johannes Van Den Boom

IPC: G06F19/24 ,  G06F19/22

CPC classification number: G16B40/00 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  G16B20/00 ,  G16B30/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information.

Abstract translation: 本文提供了利用核酸片段长度信息对遗传变异进行非侵入性评估的方法，过程和装置。