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21.发明申请METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS 有权用于改善CD138表达肿瘤细胞靶向的方法和试剂公开(公告)号：US20090169570A1
公开(公告)日：2009-07-02
申请号：US12342815
申请日：2008-12-23
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K2317/34 , C07K2317/73 , C07K2317/92
摘要： Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.
摘要翻译： 公开了对CD138具有特异性的免疫缀合物，其降低表达CD138的肿瘤细胞与基质细胞的粘附性及其使用方法。 这种粘附性降低使得肿瘤细胞不仅对免疫缀合物敏感，而且对其它试剂，特别是细胞毒性剂也是敏感的。
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22.发明申请Optimized DNA Sequence Of An Antibody To Improve Quality And Yield Of Bacterially Expressed Antibody Fusion Proteins 有权抗体优化DNA序列，提高细菌表达抗体融合蛋白的质量和产量公开(公告)号：US20110105742A1
公开(公告)日：2011-05-05
申请号：US12985542
申请日：2011-01-06
IPC分类号： C07H21/04
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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23.发明授权Optimized DNA sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins 有权优化抗体的DNA序列，以提高细菌表达的抗体融合蛋白的质量和产量公开(公告)号：US08530637B2
公开(公告)日：2013-09-10
申请号：US12985542
申请日：2011-01-06
IPC分类号： C07H21/04
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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24.发明申请OPTIMIZED DNA AND PROTEIN SEQUENCE OF AN ANTIBODY TO IMPROVE QUALITY AND YIELD OF BACTERIALLY EXPRESSED ANTIBODY FUSION PROTEINS 有权抗体的优化DNA和蛋白质序列提高细菌表达抗体融合蛋白的质量和产量公开(公告)号：US20090018079A1
公开(公告)日：2009-01-15
申请号：US12170623
申请日：2008-07-10
IPC分类号： A61K38/00 , C07K14/00 , C12N15/11 , C12N15/00 , A61P31/00 , A61K31/7088 , C12N1/20 , C12P21/04
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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25.发明授权Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins 有权优化抗体的DNA和蛋白质序列，以改善细菌表达的抗体融合蛋白的质量和产量公开(公告)号：US07887801B2
公开(公告)日：2011-02-15
申请号：US12170623
申请日：2008-07-10
IPC分类号： A61K39/00
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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