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1.发明授权Optimized DNA sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins 有权优化抗体的DNA序列，以提高细菌表达的抗体融合蛋白的质量和产量公开(公告)号：US08530637B2
公开(公告)日：2013-09-10
申请号：US12985542
申请日：2011-01-06
IPC分类号： C07H21/04
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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公开(公告)号：US6129915A
公开(公告)日：2000-10-10
申请号：US296595
申请日：1999-04-23
IPC分类号： A61K38/00 , A61K47/48 , C07K16/28 , C12N15/13 , A61K39/395
CPC分类号： C07K16/2863 , A61K47/48561 , A61K2039/505 , A61K38/00 , C07K2317/622 , C07K2319/00
摘要： The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.
摘要翻译： 本发明涉及EGF受体的单链和双链抗体。 本发明还涉及这种抗体的毒素缀合物。 这些抗体可用于治疗和诊断病理状况如癌症和细胞超增殖的状况。
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3.发明申请OPTIMIZED DNA AND PROTEIN SEQUENCE OF AN ANTIBODY TO IMPROVE QUALITY AND YIELD OF BACTERIALLY EXPRESSED ANTIBODY FUSION PROTEINS 有权抗体的优化DNA和蛋白质序列提高细菌表达抗体融合蛋白的质量和产量公开(公告)号：US20090018079A1
公开(公告)日：2009-01-15
申请号：US12170623
申请日：2008-07-10
IPC分类号： A61K38/00 , C07K14/00 , C12N15/11 , C12N15/00 , A61P31/00 , A61K31/7088 , C12N1/20 , C12P21/04
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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4.发明授权Optimized DNA and protein sequence of an antibody to improve quality and yield of bacterially expressed antibody fusion proteins 有权优化抗体的DNA和蛋白质序列，以改善细菌表达的抗体融合蛋白的质量和产量公开(公告)号：US07887801B2
公开(公告)日：2011-02-15
申请号：US12170623
申请日：2008-07-10
IPC分类号： A61K39/00
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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公开(公告)号：US5942602A
公开(公告)日：1999-08-24
申请号：US800198
申请日：1997-02-13
CPC分类号： C07K16/2863 , A61K47/48561 , A61K2039/505 , A61K38/00 , C07K2317/622 , C07K2319/00
摘要： The present invention is related to single and double chain antibodies to EGF receptor. The invention also relates to toxin conjugates of such antibodies. These antibodies are useful for treating and diagnosing the status of pathological conditions such as cancer and cellular hyper proliferation.
摘要翻译： 本发明涉及EGF受体的单链和双链抗体。 本发明还涉及这种抗体的毒素缀合物。 这些抗体可用于治疗和诊断病理状况如癌症和细胞超增殖的状况。
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6.发明申请Optimized DNA Sequence Of An Antibody To Improve Quality And Yield Of Bacterially Expressed Antibody Fusion Proteins 有权抗体优化DNA序列，提高细菌表达抗体融合蛋白的质量和产量公开(公告)号：US20110105742A1
公开(公告)日：2011-05-05
申请号：US12985542
申请日：2011-01-06
IPC分类号： C07H21/04
CPC分类号： C07K16/32 , A61K31/7088 , C07K14/21 , C07K2317/622 , C07K2319/00 , C07K2319/55
摘要： Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
摘要翻译： 本发明的目的是编码scFv（FRP5）抗体片段的优化的DNA序列。 该新型序列防止在scFv（FRP5）-ETA融合蛋白以及可能还有其它细菌表达的scFv（FRP5）融合蛋白的上下文中产生不需要的副产物。 通过交换不同的密码子修饰scFv（FRP5）-ETA的scFv（FRP5）结构域的DNA序列，从而防止蛋白质翻译的另外可能的内部启动。
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公开(公告)号：US5571894A
公开(公告)日：1996-11-05
申请号：US235838
申请日：1994-04-29
申请人： Winfried S. Wels , Nancy E. Hynes , Ina-Maria Harweth , Bernd Groner , Norman Hardman , Markus Zwickl
发明人： Winfried S. Wels , Nancy E. Hynes , Ina-Maria Harweth , Bernd Groner , Norman Hardman , Markus Zwickl
CPC分类号： C07K16/32 , A61K38/00 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacturing those recombinant and monoclonal antibodies, hybridoma cells secreting those monoclonal antibodies, a method of manufacturing those hybridoma cells, DNAs encoding the heavy and light chain variable domains and the recombinant antibody, a method of manufacturing that DNA, hybrid vectors suitable for the expression of that DNA, host cells transformed with that DNA, and processes of using those recombinant and monoclonal antibodies in the diagnosis and treatment of tumors.
摘要翻译： 本发明涉及针对人生长因子受体c-erbB-2细胞外结构域的重组抗体，其包含轻链可变结构域和单克隆抗体的重链可变区，针对c-erbB-2本身的单克隆抗体， 制备这些重组和单克隆抗体的方法，分泌这些单克隆抗体的杂交瘤细胞，制备这些杂交瘤细胞的方法，编码重链和轻链可变区的DNA和重组抗体，制备该DNA的方法，适用于 该DNA的表达，用该DNA转化的宿主细胞，以及使用这些重组和单克隆抗体进行肿瘤诊断和治疗的过程。
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