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公开(公告)号：US09211362B2
公开(公告)日：2015-12-15
申请号：US13491985
申请日：2012-06-08
申请人： Julia Hwang , Joseph Hammer , Herb Schwartz , Prasanna Malaviya
发明人： Julia Hwang , Joseph Hammer , Herb Schwartz , Prasanna Malaviya
CPC分类号： A61L27/3604 , A61F2/08 , A61F2002/0852 , A61F2210/0004 , A61F2250/0015 , A61F2250/0028 , A61L27/18 , A61L27/3641 , A61L27/3645 , A61L27/3662 , A61L27/3691 , A61L27/56 , A61L27/58 , C08L67/04
摘要： A connective tissue scaffold including opposed first and second anchoring segments formed from a plurality of bioresorbable polymeric fibers oriented in a direction substantially parallel to a longitudinal axis of the scaffold and a plurality of bioresorbable polymeric fibers oriented in a direction substantially transverse to a longitudinal axis of the scaffold. A central segment joins the first and second anchoring segments and includes a plurality of bioresorbable polymeric fibers oriented in a direction substantially parallel to the longitudinal axis of the scaffold. The scaffold can also a tissue particle and/or biological component.
摘要翻译： 一种结缔组织支架，其包括相对的第一和第二锚定段，所述第一和第二锚定段由多个生物可再吸收的聚合物纤维形成，所述多个生物可再吸收的聚合物纤维在基本上平行于所述支架的纵向轴线的方向上定向;以及多个生物可再吸收的聚合物纤维， 脚手架 中心段连接第一和第二锚固段，并且包括沿基本上平行于支架的纵向轴线的方向取向的多个生物可再吸收的聚合物纤维。 支架也可以是组织颗粒和/或生物组分。
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公开(公告)号：US08637066B2
公开(公告)日：2014-01-28
申请号：US12887011
申请日：2010-09-21
IPC分类号： A61F2/00
CPC分类号： A61L27/3683 , A61F2/08 , A61L27/3604 , A61L27/3662 , A61L2430/10
摘要： A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译： 提供生物相容性韧带修复植入物或支架装置用于修复各种韧带组织损伤。 修复过程可以用韧带修复植入物进行，其包含有助于愈合或组织修复的生物成分。 生物相容性韧带修复植入物包括衍生自韧带组织或腱组织的生物相容性支架和活组织颗粒，使得组织和支架变得相关联。 活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。
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公开(公告)号：US20130005681A1
公开(公告)日：2013-01-03
申请号：US13173658
申请日：2011-06-30
申请人： Dongling Su , Julia Hwang , Brooks J. Story
发明人： Dongling Su , Julia Hwang , Brooks J. Story
IPC分类号： A61K31/728 , A61P29/00 , A61P19/04 , A61P19/02
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K31/726 , A61K31/728 , A61K31/737 , A61K47/02 , A61K47/10 , A61K2300/00
摘要： Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluronic acid (“HA”), in combination with at least one stabilizer. The composition can include a stabilizer that increases the stability and shelf-life of the HA. In another embodiment, the compositions and methods can also include an additional component, such as one or more glycosaminoglycans (“GAG”) or GAG precursors. Examples of GAGs or GAG precursors can include chondroitin sulfate (“CS”), dermatan sulfate, heparin, heparan sulfate, keratan sulfate, and glucosamine (“GlcN”).
摘要翻译： 提供组合物和方法用于治疗关节病，例如骨关节炎和/或与之相关的疼痛。 组合物和方法利用第一组分，即透明质酸（HA）与至少一种稳定剂的组合。 组合物可以包括增加HA的稳定性和保质期的稳定剂。 在另一个实施方案中，组合物和方法还可以包括另外的组分，例如一种或多种糖胺聚糖（GAG）或GAG前体。 GAG或GAG前体的实例可包括硫酸软骨素（CS），硫酸皮肤素，肝素，硫酸乙酰肝素，硫酸角质素和葡糖胺（GlcN）。
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公开(公告)号：US07901461B2
公开(公告)日：2011-03-08
申请号：US10729046
申请日：2003-12-05
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/38 , A61L2430/06
摘要： Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
摘要翻译： 提供生物相容性组织植入物用于修复组织损伤或缺损。 组织植入物包括用作可进行组织再生和/或修复的活细胞来源的生物组织切片。 生物组织切片可以从健康组织收获，以具有适合于在损伤或缺损部位植入的几何形状。 将收获的组织切片的尺寸设定为允许包含在组织切片内的活细胞移出并增殖并与损伤或缺损部位周围的组织整合。 还提供了使用组织植入物修复组织损伤或缺陷的方法。
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公开(公告)号：US20050130879A1
公开(公告)日：2005-06-16
申请号：US11045714
申请日：2005-01-28
申请人： Julia Hwang , Samuel Stupp
发明人： Julia Hwang , Samuel Stupp
IPC分类号： A61K31/728 , A61K38/00 , A61L27/34 , A61L27/36 , A61L27/50
CPC分类号： A61K31/728 , A61L27/34 , A61L27/36 , A61L27/50 , C08L89/00
摘要： A method for modifying the surface properties of tissue in vivo is described. The method comprises forming a liquid crystalline matrix on the tissue surface wherein the matrix comprises a tissue surface component. In one embodiment there is provided a method for improving the bonding of surgical glues and cements to cartilage and other synovial fluid wetted tissue surfaces. Such surfaces are contacted with a composition comprising a poly(hydroxy substituted amino acid) to form a liquid crystalline matrix on the tissue surface. The matrix is readily removed to provide a tissue surface that exhibits improved bonding with surgical glues.
摘要翻译： 描述了一种修饰体内组织表面性质的方法。 该方法包括在组织表面上形成液晶基质，其中基质包括组织表面组分。 在一个实施方案中，提供了一种用于改善外科胶水和水泥与软骨和其它滑液润湿组织表面的结合的方法。 这样的表面与包含聚（羟基取代的氨基酸）的组合物接触以在组织表面上形成液晶基质。 容易移除基质以提供表现出改善的与手术胶粘结的组织表面。
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公开(公告)号：US08641775B2
公开(公告)日：2014-02-04
申请号：US13018900
申请日：2011-02-01
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/38 , A61L2430/06
摘要： Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
摘要翻译： 提供生物相容性组织植入物用于修复组织损伤或缺损。 组织植入物包括用作可进行组织再生和/或修复的活细胞来源的生物组织切片。 生物组织切片可以从健康组织收获，以具有适合于在损伤或缺损部位植入的几何形状。 将收获的组织切片的尺寸设定为允许包含在组织切片内的活细胞移出并增殖并与损伤或缺损部位周围的组织整合。 还提供了使用组织植入物修复组织损伤或缺陷的方法。
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公开(公告)号：US08398611B2
公开(公告)日：2013-03-19
申请号：US12979981
申请日：2010-12-28
申请人： Julia Hwang , Dongling Su , Julius Lopez
发明人： Julia Hwang , Dongling Su , Julius Lopez
IPC分类号： A61M31/00
CPC分类号： A61K31/728 , A61K9/0019 , A61K31/7008 , A61K31/737 , A61M5/19 , A61M5/2066 , A61K2300/00
摘要： Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”).
摘要翻译： 提供组合物和方法用于治疗关节病，例如骨关节炎和/或与之相关的疼痛。 组合物和方法利用第一组分，即透明质酸（HA）与冻干的第二组分组合，其有效地至少暂时降低HA的粘度。 在一个示例性实施方案中，第二组分是一种或多种糖胺聚糖（GAG），例如硫酸软骨素（CS），包括CS4和/或CS6，硫酸皮肤素，肝素，硫酸乙酰肝素和硫酸角质素。 组合物可任选地包括其它联合补充剂，例如葡糖胺（GlcN）。
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公开(公告)号：US20110009963A1
公开(公告)日：2011-01-13
申请号：US12887011
申请日：2010-09-21
CPC分类号： A61L27/3683 , A61F2/08 , A61L27/3604 , A61L27/3662 , A61L2430/10
摘要： A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译： 提供生物相容性韧带修复植入物或支架装置用于修复各种韧带组织损伤。 修复过程可以用韧带修复植入物进行，其包含有助于愈合或组织修复的生物成分。 生物相容性韧带修复植入物包括衍生自韧带组织或腱组织的生物相容性支架和活组织颗粒，使得组织和支架变得相关联。 活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。
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公开(公告)号：US08524662B2
公开(公告)日：2013-09-03
申请号：US12979972
申请日：2010-12-28
申请人： Ben Byers , Dongling Su , Julia Hwang
发明人： Ben Byers , Dongling Su , Julia Hwang
CPC分类号： A61K31/728 , A61K38/1875 , A61K2300/00
摘要： Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.
摘要翻译： 公开了用于治疗骨关节炎的关节内注射的方法和组合物。 包括透明质酸和骨形态发生蛋白（如rhGDF-5）的组合的方法和组合物可用于任何滑膜关节，包括膝盖，肩部，髋，踝，踝关节，手，脊柱小面或颞下颌关节， 缓解疼痛和减缓疾病进展。
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公开(公告)号：US20110177134A1
公开(公告)日：2011-07-21
申请号：US13018900
申请日：2011-02-01
IPC分类号： A61K35/12 , A61K35/32 , A61K35/38 , A61K35/22 , A61K35/407 , A61K35/36 , A61K35/42 , A61K9/00 , A61P17/02 , A61P19/02
CPC分类号： A61L27/3683 , A61L27/38 , A61L2430/06
摘要： Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
摘要翻译： 提供生物相容性组织植入物用于修复组织损伤或缺损。 组织植入物包括用作可进行组织再生和/或修复的活细胞来源的生物组织切片。 生物组织切片可以从健康组织收获，以具有适合于在损伤或缺损部位植入的几何形状。 将收获的组织切片的尺寸设定为允许包含在组织切片内的活细胞移出并增殖并与损伤或缺损部位周围的组织整合。 还提供了使用组织植入物修复组织损伤或缺陷的方法。
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