公开(公告)号：US08026104B2

公开(公告)日：2011-09-27

申请号：US11875942

申请日：2007-10-21

申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： G01N27/00 ,  G01N27/413

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

公开(公告)号：US20110061458A1

公开(公告)日：2011-03-17

申请号：US12949645

申请日：2010-11-18

申请人： Dijia Huang ,  Steven C. Charlton ,  Suny J. George ,  Andrew J. Edelbrock

发明人： Dijia Huang ,  Steven C. Charlton ,  Suny J. George ,  Andrew J. Edelbrock

IPC分类号： G01F23/24

CPC分类号： G01N27/3272 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/3275 ,  G01N27/4163 ,  Y10T29/49082 ,  Y10T29/49099

摘要： According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.

摘要翻译： 根据本发明的一个实施例，公开了一种用于检测流体测试样品中分析物浓度的电化学传感器（10）。 传感器（10）包括具有高电阻部分的对电极，用于检测测试传感器是否已接收到预定量的样本。

公开(公告)号：US20120244295A1

公开(公告)日：2012-09-27

申请号：US13488882

申请日：2012-06-05

申请人： Greg P. Beer ,  Andrew J. Edelbrock

发明人： Greg P. Beer ,  Andrew J. Edelbrock

IPC分类号： B05D3/06

CPC分类号： G01N27/3272

摘要： A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer.

摘要翻译： 形成电化学测试传感器的方法包括提供基底。 将电化学活性材料放置在基底上。 介电材料涂覆在电化学活性材料上。 电介质材料的第一选择区域被激光烧蚀以暴露电化学活性材料。 电介质材料和电化学活性材料的第二选择区域被激光烧蚀以露出基底。 第一选区与第二选区不同。 施加第二层以辅助在测试传感器中形成通道。 该通道有助于允许流体样品​​与位于其中的试剂接触。 介电材料位于基底和第二层之间。

公开(公告)号：US20090152128A1

公开(公告)日：2009-06-18

申请号：US12083952

申请日：2006-11-13

申请人： Amy H. Chu ,  Andrew J. Edelbrock ,  Hope G. Spradlin

发明人： Amy H. Chu ,  Andrew J. Edelbrock ,  Hope G. Spradlin

IPC分类号： G01N33/50 ,  G01N33/52

CPC分类号： C12Q1/26 ,  C12Q1/006

摘要： A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.

摘要翻译： 用于测量体液中分析物浓度的测试传感器试剂包括用于改善测试传感器的稳定性并减少总测定时间的纤维素聚合物。 测试传感器试剂还包括酶，电子转移介体和流变添加剂。

公开(公告)号：US20090075213A1

公开(公告)日：2009-03-19

申请号：US11918826

申请日：2006-04-18

申请人： Andrew J. Edelbrock

发明人： Andrew J. Edelbrock

IPC分类号： H01L21/70

CPC分类号： G01N33/48771 ,  A61B5/1486 ,  H05K1/0286 ,  H05K3/027

摘要： An auto-calibration circuit or label (20) is formed to be used with an instrument (10). A structure is provided that includes an electrically conductive layer. A pattern is created with the electrically conductive layer using a laser to form an auto-calibration circuit or label. The pattern is adapted to be utilized by the instrument to auto-calibrate. The pattern may be adapted to be utilized for a first instrument and a second instrument to auto-calibrate in which the first and second instruments are different.

摘要翻译： 形成与仪器（10）一起使用的自动校准电路或标签（20）。 提供了包括导电层的结构。 使用激光形成具有导电层的图案以形成自动校准电路或标签。 该模式适用于仪器自动校准。 该图案可以适于用于第一仪器和第二仪器以自动校准，其中第一和第二仪器不同。

公开(公告)号：USRE44521E1

公开(公告)日：2013-10-08

申请号：US12257031

申请日：2008-10-23

申请人： Matthew K. Musho ,  J. Oakey Noell ,  Andrew J. Edelbrock ,  Dijia Huang

发明人： Matthew K. Musho ,  J. Oakey Noell ,  Andrew J. Edelbrock ,  Dijia Huang

IPC分类号： G01N27/327

CPC分类号： C12Q1/001 ,  G01N27/3274

摘要： An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.

公开(公告)号：US08399070B2

公开(公告)日：2013-03-19

申请号：US13488882

申请日：2012-06-05

申请人： Greg P. Beer ,  Andrew J. Edelbrock

发明人： Greg P. Beer ,  Andrew J. Edelbrock

IPC分类号： B05D3/00 ,  C12Q1/00

CPC分类号： G01N27/3272

摘要： A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer.

摘要翻译： 形成电化学测试传感器的方法包括提供基底。 将电化学活性材料放置在基底上。 介电材料涂覆在电化学活性材料上。 电介质材料的第一选择区域被激光烧蚀以暴露电化学活性材料。 电介质材料和电化学活性材料的第二选择区域被激光烧蚀以露出基底。 第一选区与第二选区不同。 施加第二层以辅助在测试传感器中形成通道。 该通道有助于允许流体样品​​与位于其中的试剂接触。 介电材料位于基底和第二层之间。

公开(公告)号：US08273226B2

公开(公告)日：2012-09-25

申请号：US12316113

申请日：2008-12-09

申请人： Andrew J. Edelbrock

发明人： Andrew J. Edelbrock

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  Y10T156/1082

摘要： An electrochemical test sensor includes a base, a generally hard electrically-conductive layer, an electrochemically-active layer, and a lid. The electrically-conductive layer is located between the base and the electrochemically-active layer. The electrically-conductive layer and the electrochemically-active layer are made of a different material. The electrically-conductive layer and the electrochemically-active layer form an electrode pattern. The electrochemical test sensor includes a reagent adapted to assist in determining information related to an analyte of a fluid sample.

摘要翻译： 电化学测试传感器包括基底，通常硬的导电层，电化学活性层和盖。 导电层位于基底和电化学活性层之间。 导电层和电化学活性层由不同的材料制成。 导电层和电化学活性层形成电极图案。 电化学测试传感器包括适于帮助确定与流体样品的分析物相关的信息的试剂。

公开(公告)号：US20090145755A1

公开(公告)日：2009-06-11

申请号：US12316113

申请日：2008-12-09

申请人： Andrew J. Edelbrock

发明人： Andrew J. Edelbrock

IPC分类号： G01N27/26 ,  B32B37/00 ,  B32B38/04 ,  B32B38/00 ,  C23C14/34

CPC分类号： G01N27/3272 ,  Y10T156/1082

摘要： An electrochemical test sensor includes a base, a generally hard electrically-conductive layer, an electrochemically-active layer, and a lid. The electrically-conductive layer is located between the base and the electrochemically-active layer. The electrically-conductive layer and the electrochemically-active layer are made of a different material. The electrically-conductive layer and the electrochemically-active layer form an electrode pattern. The electrochemical test sensor includes a reagent adapted to assist in determining information related to an analyte of a fluid sample.

摘要翻译： 电化学测试传感器包括基底，通常硬的导电层，电化学活性层和盖。 导电层位于基底和电化学活性层之间。 导电层和电化学活性层由不同的材料制成。 导电层和电化学活性层形成电极图案。 电化学测试传感器包括适于帮助确定与流体样品的分析物相关的信息的试剂。

公开(公告)号：US06841052B2

公开(公告)日：2005-01-11

申请号：US09861437

申请日：2001-05-21

申请人： Matthew K. Musho ,  J. Oakey Noell ,  Andrew J. Edelbrock ,  Dijia Huang

发明人： Matthew K. Musho ,  J. Oakey Noell ,  Andrew J. Edelbrock ,  Dijia Huang

IPC分类号： C12Q1/00 ,  G01N33/487 ,  G01N27/327 ,  G01N27/333

CPC分类号： C12Q1/001 ,  G01N27/3274

摘要： An improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working and counter electrodes are configured so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode. This configuration enables the sensor when the capillary space is incompletely filled with test fluid.

摘要翻译： 一种改进的电化学传感器，其具有承载工作和对电极的基座，其提供用于流体测试样品的流动路径。 工作电极和对电极被构造成使得相对电极的主要部分位于与工作电极相距的流动路径的下游，除了对电极的小子元件之外，该小子元件与主电极 对置电极并位于工作电极的上游。 当毛细管空间未完全填充测试流体时，该配置使得传感器成为可能。