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21.发明申请公开(公告)号：US20060073150A1
公开(公告)日：2006-04-06
申请号：US10236878
申请日：2002-09-06
申请人： Mary Faris , Wangmao Ge , Arthur Raitano , Pia Challita-Eid , Aya Jakobovits
发明人： Mary Faris , Wangmao Ge , Arthur Raitano , Pia Challita-Eid , Aya Jakobovits
IPC分类号： A61K39/395
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2319/00 , G01N33/57484
摘要： A novel gene 08P1D4 (also designated STEAP-1) and its encoded protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
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22.发明申请公开(公告)号：US20060052321A1
公开(公告)日：2006-03-09
申请号：US11068859
申请日：2005-02-28
申请人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
发明人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
CPC分类号： C07K14/47
摘要： A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.
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公开(公告)号：US20060029940A1
公开(公告)日：2006-02-09
申请号：US10857484
申请日：2004-05-28
申请人： Wangmao Ge , Pia Challita-Eid , Arthur Raitano , Aya Jakobovits
发明人： Wangmao Ge , Pia Challita-Eid , Arthur Raitano , Aya Jakobovits
CPC分类号： C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要： PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, propylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
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24.发明申请Nucleic acid and corresponding protein entitled 121P2A3 useful in treatment and detection of cancer 审中-公开核酸和相应的蛋白质121P2A3可用于治疗和检测癌症公开(公告)号：US20050214211A1
公开(公告)日：2005-09-29
申请号：US11073349
申请日：2005-03-03
申请人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Steven Mitchell , Daniel Afar , Douglas Saffran , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Steven Mitchell , Daniel Afar , Douglas Saffran , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A01K67/027 , A61K39/395 , A61K51/00 , C07K14/47 , C07K16/40 , C12N5/06
CPC分类号： C07K14/47
摘要： A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 121P2A3 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为121P2A3）及其编码的蛋白质及其变体，其中121P2A3在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，121P2A3提供诊断，预后， 癌症的预防和/或治疗靶标。 121P2A3基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与121P2A3反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20060275211A1
公开(公告)日：2006-12-07
申请号：US11396178
申请日：2006-03-31
申请人： Aya Jakobovits , Steven Kanner , Pia Challita-Eid , Juan Perez-Villar , Daulet Satpaev , Arthur Raitano , Robert Morrison , Karen Morrison , Xiao-Chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven Kanner , Pia Challita-Eid , Juan Perez-Villar , Daulet Satpaev , Arthur Raitano , Robert Morrison , Karen Morrison , Xiao-Chi Jia , Jean Gudas
IPC分类号： A61K51/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82 , C07K16/30 , C07K16/46
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
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公开(公告)号：US20050221400A1
公开(公告)日：2005-10-06
申请号：US11131648
申请日：2005-05-17
申请人： Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Morrison , Karen Morrison , Hui Shao , Pia Challita-Eid , Arthur Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Morrison , Karen Morrison , Hui Shao , Pia Challita-Eid , Arthur Raitano
IPC分类号： C07K20060101 , C07K14/47 , C07K14/705 , C07K16/30 , C07K16/46 , C12N20060101 , G01N33/574
CPC分类号： A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , A61K2039/545 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/34 , C07K2317/73 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57492 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20050208059A1
公开(公告)日：2005-09-22
申请号：US11125805
申请日：2005-05-09
申请人： Pia Challita-Eid , Rene Hubert , Steve Mitchell , Arthur Raitano , Mary Faris , Daniel Afar , Aya Jakobovits
发明人： Pia Challita-Eid , Rene Hubert , Steve Mitchell , Arthur Raitano , Mary Faris , Daniel Afar , Aya Jakobovits
IPC分类号： A61K38/00 , C07K14/47 , G01N33/574 , C12Q1/68 , A61K39/395 , C07K14/82 , C07K16/30
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , Y02A50/465 , Y02A50/473
摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
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28.发明申请Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权核酸和相应的标题为161P2F10B的蛋白质可用于治疗和检测癌症公开(公告)号：US20070004913A1
公开(公告)日：2007-01-04
申请号：US10860769
申请日：2004-06-02
申请人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Aya Jakobovits
发明人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Aya Jakobovits
CPC分类号： C07K14/47 , A61K39/00 , C07K16/40 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , Y02A50/466
摘要： A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response.
摘要翻译： 描述了一种基因（命名为161P2F10B）及其编码的蛋白质，其中161P2F10B在正常成人组织中表现出组织特异性表达，其在表I中列出的癌症中异常表达。因此，161P2F10B提供诊断，预后，预防和/或治疗靶标 为癌症。 161P2F10B基因或其片段或其编码的蛋白质或其片段可用于引发体液或细胞免疫应答。
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公开(公告)号：US20060147375A1
公开(公告)日：2006-07-06
申请号：US11355464
申请日：2006-02-15
申请人： Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Morrison , Pia Challita-Eid , Arthur Raitano
发明人： Jean Gudas , Aya Jakobovits , Xiao-Chi Jia , Robert Morrison , Pia Challita-Eid , Arthur Raitano
IPC分类号： A61K51/00 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C12N5/06
CPC分类号： G01N33/57492 , A61K39/0011 , A61K47/6869 , A61K49/0002 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/21 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G01N33/566 , G01N33/57415 , G01N33/57434 , G01N33/57484 , G01N2500/04
摘要： Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization. CROSS-REFERENCE TO RELATED APPLICATIONS
摘要翻译： 其中PSCA在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后， 癌症的预防和/或治疗靶标。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。 相关申请的交叉引用
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30.发明申请公开(公告)号：US20060002993A1
公开(公告)日：2006-01-05
申请号：US10859643
申请日：2004-06-02
申请人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Aya Jakobovits
发明人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Aya Jakobovits
CPC分类号： C07K14/47 , A61K39/00 , C07K16/40 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , Y02A50/466
摘要： A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit a humoral or cellular immune response.
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