摘要:
There is provided an industrial production method of an aminopyrrolidine derivative having chemokine receptor antagonist activity represented by the following formula, a synthetic intermediate thereof and a production method thereof: wherein R11 is H, C1-C6 alkyl or C2-C7 alkanoyl; R12, R14, R15, R16 and R17 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy, hydroxyl or C2-C7 alkoxycarbonyl; R23, R24, R25 and R26 are H, halogen, optionally halogenated C1-C6 alkyl, optionally halogenated C1-C6 alkoxy or hydroxyl; and R3 is H or C1-C6 alkyl.
摘要翻译:提供了具有下式表示的趋化因子受体拮抗剂活性的氨基吡咯烷衍生物及其合成中间体及其制备方法的工业生产方法:其中R 11是H,C 1 C 6 -C 6烷基或C 2 -C 7烷酰基; R 12,R 14,R 15,R 16和R 17均为 H,卤素,任选卤代C 1 -C 6烷基,任意卤代C 1 -C 6烷氧基, 羟基或C 2 -C 7烷氧基羰基; R 23,R 24,R 25和R 26是H,卤素,任选卤代的C 1 -C 12烷基, C 1 -C 6烷基,任选卤代C 1 -C 6烷氧基或羟基; R 3是H或C 1 -C 6烷基。
摘要:
A printer apparatus has a thermal head for printing by making contact with a heat-sensitive coloring layer of a heat-sensitive adhesive sheet comprised of the heat-sensitive coloring layer and a heat-sensitive adhesive layer formed on opposite sides of a sheet-like base material. A thermal head heats the heat-sensitive adhesive layer to activate the same, and a conveying roller conveys the heat-sensitive adhesive sheet in a predetermined direction to an ejection hole which ejects the heat-sensitive adhesive sheet out of the apparatus. A sheet holding unit holds the printed sheet with part of the same exposed to the outside from the ejection hole.
摘要:
A printer has a printing unit for printing during a printing operation on a printable surface of a thermally sensitive adhesive sheet having a thermally sensitive adhesive layer formed on a surface opposite to the printable surface. A first transporting mechanism transports the thermally sensitive adhesive sheet through the printing unit. A thermally activating unit heats the thermally sensitive adhesive layer of the thermally sensitive adhesive sheet and has a second transporting mechanism for transporting the thermally sensitive adhesive sheet through the thermally activating unit. A third transporting mechanism transports the thermally sensitive adhesive sheet from the printing unit to the thermally activating unit. A control device independently controls the first and second transporting mechanisms to thereby independently control a transporting speed of the thermally sensitive adhesive sheet during transportation thereof by the first and second transporting mechanisms.
摘要:
An optical isolator having an optical element, comprised of an incoming side polarizer, a Faraday rotator, and an outgoing side polarizer superposed in the order of mention in the direction of an optical path, is embedded in the optical path of an optical fiber or optical waveguide having a light axis. The isolator has a slot extending across the light axis in a direction slanted with respect to the light axis. The optical element is inserted in the slot and the spaces between the optical element and the incoming and outgoing sides of the slot are filled with an optical adhesive portion. At least one of the interfaces is inclined at an angle reversely from the plane normal to the light axis as viewed from the slanted incoming side of the slot.
摘要:
A thermally activating apparatus comprises a main body frame (1), a thermal head (4) for heating a sheet, a first head holding member (5a) for holding the thermal head from a back portion thereof, a platen roller (2) arranged in parallel with the thermal head and paper feeding means (8a through 8c) for transporting the sheet after having been heated by the thermal head, and a second head holding member (5b) having a first support shaft (6a) in parallel with the thermal head and the holding the first head holding member pivotably by the first support shaft, wherein the second head holding member is pivotably supported by a second support shaft (6b) arranged in parallel with the thermal head and transversely hung rotatably between side walls of the main body frame and the thermal head is constituted to be able to be proximate to and remote from the platen roller by constituting centers of rotation by two shafts of the first support shaft and the second support shaft.
摘要:
A thermal activation device includes a platen lock mechanism (19) for locking a platen roller (12) and a thermal activation head (11) into press contact with each other, the platen lock mechanism (19) including lock arms (32a and 32b) provided to be rotatable and engaged with a platen unit (18), and a compression coil spring (24) which urges the lock arms (32a and 32b) so as to bring the lock arms (32a and 32b) into engagement with the platen roller (18). The plate lock mechanism (19) includes lock pins (33) provided in the platen unit (18), and engagement grooves (37) which are provided in the lock arms (32a and 32b) and with which the lock pins (33) are engaged. Moreover, in the platen lock mechanism (19), in a state where the thermal activation head (11) is in press contact with the platen roller (12), an axis of the lock pins (33) is provided at a position farther than a position of a rotation center of the platen roller (12) with respect to a rotation center of the lock arms (32a and 32b).
摘要:
An anchor 1 adapted to an undercut-type prepared hole 19 having near the hole bottom thereof a diameter expanded in a taper way and including a sleeve 2 having an expansion part 6 and a plug 3 formed with a tapered part 14 inserted into the sleeve 2 for expanding the expansion part 6. When the plug 3 is hammered with the sleeve 2 contacting the bottom of the prepared hole, an annular projecting part 13 and an engagement groove 7 are engaged in a concavo-convex way as the expansion part 6 expands to contact a tapered surface 21a of the prepared hole 19. At the same time, by a hole-bottom reaction force generated by the plug 3 contacting the bottom of the prepared hole 19, a construction is completed with the expansion part 6 making press contact with the tapered surface 21a of the prepared hole. Concurrently with completion of the construction, the tensile strength equal to that of the steel product and the like can be obtained immediately without adding an external tensile force.
摘要:
Beams of light emitted from a light source 1 are incident on a polarizer 14. In the event that the direction of a transmission axis of the polarizer 14 is adjusted in advance such that the polarizer 14 transmits P polarized light, only S polarized light can be attenuated. Beams of light which transmit through a diffracting device 2 and a collimator lens 3 for incidence on a beam splitter 4a are made up substantially only by P polarized light. Part of the beams of light, which is reflected on the beam splitter 4a, is incident on a photodetector 13 for use for feedback control of outputs from the light source 1. Since S polarized light is attenuated by the polarizer 14, only P polarized light is incident on the photodetector 13. Consequently, even in case the quantity of emitted laser beams changes, a ratio between the quantity of light for record and reproduction and the quantity of light for APC remains substantially constant, whereby the accuracy of detecting the intensity of laser beams can be increased, thereby making it possible to avoid errors in record and reproduction.
摘要:
A fastener in which a sleeve 3 and a plug 4 are put into concavo-convex engagement both before and after execution to exert an effect of preventing separation between the two and an effect of preventing loosening therebetween after execution and which can be released by a single action during disassembling. Before execution, the sleeve 3 and the plug 4 press fitted therein are positioned by concavo-convex engagement between a fitting protrusion 8 on the inner periphery of an expanding portion 7 and a neck portion 11 of the plug 4. After execution, the fitting protrusion 8 on the inner periphery of the expanding portion 7 as expanded put into concavo-convex engagement with a neck portion 10 of the plug 4 again, thereby exerting an effect of stopping loosening between the two with respect to vibration, etc. During disassembling, a striking force is given to an end of the plug 4 to release the expanded state by a single action, allowing immediate pulling-away of the fastener 1.
摘要:
To provide a thermal activation device which enables reduced power consumption and reduced device volume while effecting a clear separation between an activation portion and a non-activation portion of a thermal activation label. The thermal activation device for heating a thermal activation sheet by using a thermal head having heat generating elements formed therein, including a radiator adapted to absorb and dissipate a heat of the thermal head and having a portion of the radiator arranged in contact with an introduction path along which the thermal activation sheet is introduced toward the thermal head, the portion of the radiator being brought into contact with the thermal activation sheet to effect preheating as the thermal activation sheet advances in the introduction path.