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公开(公告)号：US10799360B2
公开(公告)日：2020-10-13
申请号：US15968000
申请日：2018-05-01
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Samir Kapadia
Abstract: A system for treating regurgitation of blood through a diseased heart valve having at least two leaflets can include an implantable, lollipop-shaped device and an adjustment mechanism. The device can have a proximal end portion, a distal end portion, and an intermediate portion extending therebetween. The intermediate portion can include an expandable occluding member having a selectively adjustable diameter and a biocompatible layer attached to at least a portion thereof. The distal end portion can include an anchoring member. The adjustment member can include a distal connecting end that is operatively connected to the proximal end portion of the device. Operation of the adjustment member, after implantation of the device, can cause the diameter of the occluding member to change so that at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve.
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Patent Agency Ranking
22.发明授权公开(公告)号：US10537432B2
公开(公告)日：2020-01-21
申请号：US15677470
申请日：2017-08-15
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Jose L. Navia , Samir Kapadia , Marwane Berrada
IPC: A61F2/24
Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.
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公开(公告)号：US10213304B2
公开(公告)日：2019-02-26
申请号：US14883819
申请日：2015-10-15
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Samir Kapadia
Abstract: An apparatus for treating regurgitation of blood through a diseased heart valve having at least two leaflets includes a lollipop-shaped body member having a proximal end portion, a distal end portion, and an intermediate portion extending between the end portions. The intermediate portion includes an expandable occluding member having an adjustable diameter so that, during at least a portion of the cardiac cycle, at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve. The proximal end portion is physically connected to the occluding member and includes a connecting mechanism for operably mating with an adjustment member for adjusting the position and diameter of the occluding member within the diseased heart valve. The distal end portion includes an anchoring member for securing the apparatus in a heart chamber containing the diseased heart valve.
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公开(公告)号：US10039644B2
公开(公告)日：2018-08-07
申请号：US14737591
申请日：2015-06-12
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Jose L. Navia , Samir Kapadia
IPC: A61F2/24
Abstract: In one aspect of the present disclosure, a device for treating a regurgitant heart valve in a subject can include a flexible, elongated body having a central chordae support portion disposed between first and second arms. The first and second arms can include first and second lumens, respectively, extending longitudinally therethrough. A method of treating a regurgitant heart valve in a subject is also provided.
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公开(公告)号：US09498584B2
公开(公告)日：2016-11-22
申请号：US14060231
申请日：2013-10-22
Inventor： Samir Kapadia , Marwane Berrada , Cesar Fuentes-Ortega , Daniel Wing Fai Mok
CPC classification number: A61M5/427 , A61B17/3403 , A61B17/3478 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/22069 , A61B2017/22095 , A61B2017/3405 , A61B2017/3411 , A61B2017/3488 , A61B2018/00279 , A61B2018/00351 , A61B2018/00357 , A61B2018/0038 , A61B2018/00386 , A61B2034/2051
Abstract: An apparatus for targeting a desired target site on a body tissue comprising a wall of a first body cavity of a patient includes a target catheter. The framing member has a longitudinal framing member core defining a central framing member axis. At least one target point is carried by the framing member and is adapted for placement adjacent the desired target site. The framing member comprises a plurality of longitudinally extending multi-segment framing strands.
Abstract translation: 用于靶向包括患者的第一体腔的壁的身体组织上的所需目标部位的装置包括目标导管。 框架构件具有限定中央框架构件轴线的纵向框架构件芯部。 至少一个目标点由框架构件承载，并适于放置在所需目标位置附近。 框架构件包括多个纵向延伸的多段框架线。
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公开(公告)号：US20140155993A1
公开(公告)日：2014-06-05
申请号：US14096047
申请日：2013-12-04
Applicant: THE CLEVELAND CLINIC FOUNDATION
Inventor： Samir Kapadia
IPC: A61F2/24
CPC classification number: A61F2/2445 , A61F2/2412 , A61F2/2427 , A61F2/2466 , A61F2250/006
Abstract: One aspect of the present disclosure relates to a device for preventing or mitigating paravalvular leakage associated with a valve replacement procedure. The device can include a first ring, a second ring axially spaced apart from the first ring, at least one pad section extending between the first and second rings, and a plurality of centering wires attached to at least one of the first and second rings.
Abstract translation: 本公开的一个方面涉及一种用于防止或减轻与瓣膜置换过程相关的瓣膜下泄漏的装置。 该装置可以包括第一环，与第一环轴向间隔开的第二环，在第一和第二环之间延伸的至少一个垫部分，以及连接到第一和第二环中的至少一个的多个定心线。
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