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公开(公告)号：US11132797B2
公开(公告)日：2021-09-28
申请号：US16212027
申请日：2018-12-06
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan , Jonathan Liu , Jongsik Kim
Abstract: A multimodal imaging system and method is capable of taking fundus images, automatically identifying regions of interest (ROIs) of the eye from the fundus images, and performing OCT imaging in the identified ROIs, where the OCT images can provide clinically relevant information for screening purposes. By automatically identifying the ROIs, expert intervention is not required to perform specialized OCT imaging and thus, such imaging and analysis can be provided at more facilities and for more subjects for a lower cost.
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公开(公告)号：US20200337553A1
公开(公告)日：2020-10-29
申请号：US16855393
申请日：2020-04-22
Applicant: TOPCON CORPORATION
Inventor： Zaixing Mao , Zhenguo Wang , Bin Cao , Kinpui Chan
Abstract: A method for determining thickness of layers of the tear film includes reconstructing a full- or hyper-spectral interference pattern from an imaged multi-spectral pattern. Tear film thickness can then be estimated from the full- or hyper-spectral interference pattern. Using a full- or hyper-spectral interference pattern provides a greater number of frequency sampling points for increased tear film thickness estimation accuracy, without traditional time consuming techniques.
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公开(公告)号：US11751762B2
公开(公告)日：2023-09-12
申请号：US16719305
申请日：2019-12-18
Applicant: Topcon Corporation
Inventor： Jongsik Kim , Ying Dong , Song Mei , Kinpui Chan , Zhenguo Wang , Zaixing Mao
CPC classification number: A61B3/102 , A61B3/1225 , A61B3/14 , G01N21/17 , G01N2021/1787
Abstract: A low coherence imaging method comprises acquiring image data of an object with an interferometric imaging system, where the image data is from a location of the object at first and second times; determining a first depth profile from the image data from the location at the first time and a second depth profile from the image data of the location at the second time; determining a change with respect to depth between the first and second depth profiles; and determining a property, or identifying a location, of at least one dynamic particle in the object based on the change between the first and second depth profiles. The method is able to identify, analyze, and/or visualize dynamic particles with features comparable to at least fluorescein angiography, indocyanine green angiography, confocal scanning laser fluorescein angiography, confocal scanning laser indocyanine green angiography, and fluorescence microscopy images, without the use of a dye.
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24.发明授权公开(公告)号：US11361481B2
公开(公告)日：2022-06-14
申请号：US16574453
申请日：2019-09-18
Applicant: Topcon Corporation
Inventor： Song Mei , Zaixing Mao , Ying Dong , Zhenguo Wang , Kinpui Chan
Abstract: Shadows caused by opacities and obstructions (such as blood vessels) can block detection of structural information of objects below the shadow-causing structure, affecting visualization and analysis of those deeper structures. An image processing method for removing these shadows includes applying a low pass filter to an energy profile of an image to remove high frequency fluctuations in energy, thereby effectively recovering lower energy inside shadow regions and removing high frequency speckle. The image is then adjusted, for example by linear scaling, based on the filtered energy profile. Two dimensional filters may also be applied for volumes.
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Patent Agency Ranking
25.发明申请公开(公告)号：US20210082163A1
公开(公告)日：2021-03-18
申请号：US16574453
申请日：2019-09-18
Applicant: Topcon Corporation
Inventor： Song Mei , Zaixing Mao , Ying Dong , Zhenguo Wang , Kinpui Chan
Abstract: Shadows caused by opacities and obstructions (such as blood vessels) can block detection of structural information of objects below the shadow-causing structure, affecting visualization and analysis of those deeper structures. An image processing method for removing these shadows includes applying a low pass filter to an energy profile of an image to remove high frequency fluctuations in energy, thereby effectively recovering lower energy inside shadow regions and removing high frequency speckle. The image is then adjusted, for example by linear scaling, based on the filtered energy profile. Two dimensional filters may also be applied for volumes.
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公开(公告)号：US20210082116A1
公开(公告)日：2021-03-18
申请号：US17103058
申请日：2020-11-24
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan , Yasufumi Fukuma
Abstract: A machine learning model is trained to identify the texture difference between the different layers of a multilayer object. By training with data in full 3D space, the resulting model is capable of predicting the probability that each pixel in a 3D image belongs to a certain layer. With the resulting probability map, comparing probabilities allows one to determine boundaries between layers, and/or other properties and useful information such as volume data.
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公开(公告)号：US20200279352A1
公开(公告)日：2020-09-03
申请号：US16797848
申请日：2020-02-21
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan
Abstract: Ophthalmological mages generated by coherent imaging modalities have multiple types of noise, including random noise caused by the imaging system and speckle noise caused by turbid objects such as living tissues. These noises can occur at different levels in different locations. A noise-reduction method and system of the present disclosure thus relates to applying different filters for different types of noise and/or different locations of images, sequentially or in parallel and combined, to produce a final noise-reduced image.
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公开(公告)号：US20200163545A1
公开(公告)日：2020-05-28
申请号：US16200676
申请日：2018-11-27
Applicant: Topcon Corporation
Inventor： Yasufumi Fukuma , Hideharu Suzuki , Zhenguo Wang , Kazuhiro Oomori , Makoto Fujino
Abstract: An ophthalmologic apparatus of some exemplary embodiments includes an illumination system, interference photographing system, anterior eye segment photographing system, first optical path coupling element, and controller. The illumination system projects illumination light output from a light source, onto the anterior eye segment of a subject's eye. The interference photographing system performs photographing of an interference pattern formed on the cornea by the illumination light. The anterior eye segment photographing system performs photographing of the anterior eye segment onto which the illumination light is being projected. The first optical path coupling element couples the optical path of the interference photographing system and the optical path of the anterior eye segment photographing system with one another. The controller controls a display device to display an interference image acquired by the interference photographing system, over an anterior eye segment image acquired by the anterior eye segment photographing system.
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公开(公告)号：US20190206054A1
公开(公告)日：2019-07-04
申请号：US16212027
申请日：2018-12-06
Applicant: Topcon Corporation
Inventor： Zaixing Mao , Zhenguo Wang , Kinpui Chan , Jonathan Liu , Jongsik Kim
CPC classification number: G06T7/0014 , A61B3/102 , A61B3/12 , G06K9/4628 , G06K9/627 , G06K2209/05 , G06T7/0012 , G06T7/73 , G06T11/008 , G06T2207/10101 , G06T2207/20081 , G06T2207/30041
Abstract: A multimodal imaging system and method is capable of taking fundus images, automatically identifying regions of interest (ROIs) of the eye from the fundus images, and performing OCT imaging in the identified ROIs, where the OCT images can provide clinically relevant information for screening purposes. By automatically identifying the ROIs, expert intervention is not required to perform specialized OCT imaging and thus, such imaging and analysis can be provided at more facilities and for more subjects for a lower cost.
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