公开(公告)号：US11614321B2

公开(公告)日：2023-03-28

申请号：US16829673

申请日：2020-03-25

Applicant: TOPCON CORPORATION

Inventor： Jongsik Kim ,  Bin Cao ,  Song Mei ,  Kinpui Chan ,  Zhenguo Wang ,  Zaixing Mao

IPC: G01C1/04 ,  A61B3/10 ,  A61B3/113 ,  A61B3/14 ,  A61B3/12 ,  G01B11/06

Abstract: An interferometric method of identifying the thickness of an object that is too thin to be resolved by a Fourier transform of the interference signal includes applying a harmonic frequency modulation to an envelope of the interference signal. Where the object is a tear film, this method may be utilized to determine a thickness of the lipid layer of the tear film.

公开(公告)号：US10905325B2

公开(公告)日：2021-02-02

申请号：US16200687

申请日：2018-11-27

Applicant: Topcon Corporation

Inventor： Yasufumi Fukuma ,  Hideharu Suzuki ,  Zhenguo Wang ,  Kazuhiro Oomori ,  Makoto Fujino

IPC: A61B3/12 ,  A61B3/15 ,  A61B3/14 ,  A61B3/00 ,  A61B3/10 ,  A61B3/135

Abstract: An illumination system of an ophthalmologic apparatus of an exemplary embodiment projects illumination light from a light source onto the anterior eye segment of a subject's eye. An interference photographing system photographs an interference pattern formed on the cornea by the illumination light. An anterior eye segment photographing system photographs the anterior eye segment onto which the illumination light is being projected. A first optical path coupling element couples the optical path of the interference photographing system and the optical path of the anterior eye segment photographing system with one another. A controller controls a display device to display an observation interference image that is at least part of an interference image acquired by the interference photographing system and an anterior eye segment image acquired by the anterior eye segment photographing system together with each other, and controls the display device to display observation location information indicating a location of the observation interference image in the anterior eye segment image.

公开(公告)号：US10893796B2

公开(公告)日：2021-01-19

申请号：US16252818

申请日：2019-01-21

Applicant: Topcon Corporation

Inventor： Zhenguo Wang ,  Zaixing Mao ,  Kinpui Chan

IPC: A61B3/10 ,  G01B11/06 ,  G06T7/00 ,  G06T11/60 ,  A61B3/14 ,  A61B5/00 ,  A61B5/107

Abstract: A method for measuring layer thicknesses of a multi-layer structure includes generating first and second 2D images of the structure, each image being generated by measuring an intensity of a reflection of incident lights, from different discrete narrow spectral bands, on the structure. Thicknesses for at least one layer of the structure are then determined based on the measured reflection intensities at those locations.

公开(公告)号：US20200309510A1

公开(公告)日：2020-10-01

申请号：US16829673

申请日：2020-03-25

Applicant: TOPCON CORPORATION

Inventor： Jongsik Kim ,  Bin Cao ,  Song Mei ,  Kinpui Chan ,  Zhenguo Wang ,  Zaixing Mao

IPC: G01B11/06 ,  A61B3/113 ,  A61B3/10 ,  A61B3/14

Abstract: An interferometric method of identifying the thickness of an object that is too thin to be resolved by a Fourier transform of the interference signal includes applying a harmonic frequency modulation to an envelope of the interference signal. Where the object is a tear film, this method may be utilized to determine a thickness of the lipid layer of the tear film.

公开(公告)号：US20190231187A1

公开(公告)日：2019-08-01

申请号：US16252818

申请日：2019-01-21

Applicant: Topcon Corporation

Inventor： Zhenguo Wang ,  Zaixing Mao ,  Kinpui Chan

IPC: A61B3/10 ,  G01B11/06 ,  A61B3/14 ,  G06T7/00 ,  G06T11/60

CPC classification number: A61B3/101 ,  A61B3/1005 ,  A61B3/14 ,  A61B5/0075 ,  A61B5/1075 ,  G01B11/06 ,  G01B11/0633 ,  G06T7/0012 ,  G06T11/60 ,  G06T2207/30041

Abstract: A method for measuring layer thicknesses of a multi-layer structure includes generating first and second 2D images of the structure, each image being generated by measuring an intensity of a reflection of incident lights, from different discrete narrow spectral bands, on the structure. Thicknesses for at least one layer of the structure are then determined based on the measured reflection intensities at those locations.

公开(公告)号：US20240249393A1

公开(公告)日：2024-07-25

申请号：US18624782

申请日：2024-04-02

Applicant: TOPCON CORPORATION

Inventor： Song Mei ,  Toshihiro Mino ,  Dawei Li ,  Zaixing Mao ,  Zhenguo Wang ,  Kinpui Chan

IPC: G06T5/50 ,  A61B5/00 ,  A61B5/026 ,  G01B9/02 ,  G01B9/02091 ,  G06T7/33

CPC classification number: G06T5/50 ,  A61B5/0066 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7267 ,  A61B5/742 ,  G01B9/02041 ,  G01B9/02091 ,  G06T7/33 ,  G06T2200/04 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/20221 ,  G06T2207/30104

Abstract: Optical coherence tomography (OCT) angiography (OCTA) data is generated by one or more machine learning systems to which OCT data is input. The OCTA data is capable of visualization in three dimensions (3D) and can be generated from a single OCT scan. Further, motion artifact can be removed or attenuated in the OCTA data by performing the OCT scans according to special scan patterns and/or capturing redundant data, and by the one or more machine learning systems.

公开(公告)号：US11684253B2

公开(公告)日：2023-06-27

申请号：US16855393

申请日：2020-04-22

Applicant: TOPCON CORPORATION

Inventor： Zaixing Mao ,  Zhenguo Wang ,  Bin Cao ,  Kinpui Chan

IPC: G01J3/45 ,  A61B3/10 ,  A61B3/00 ,  A61B3/14 ,  G01B9/02 ,  G01B11/06

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/14 ,  G01B9/02041 ,  G01B9/02083 ,  G01B11/06 ,  G01J3/45

Abstract: A method for determining thickness of layers of the tear film includes reconstructing a full- or hyper-spectral interference pattern from an imaged multi-spectral pattern. Tear film thickness can then be estimated from the full- or hyper-spectral interference pattern. Using a full- or hyper-spectral interference pattern provides a greater number of frequency sampling points for increased tear film thickness estimation accuracy, without traditional time consuming techniques.

公开(公告)号：US20200163548A1

公开(公告)日：2020-05-28

申请号：US16200687

申请日：2018-11-27

Applicant: Topcon Corporation

Inventor： Yasufumi Fukuma ,  Hideharu Suzuki ,  Zhenguo Wang ,  Kazuhiro Oomori ,  Makoto Fujino

IPC: A61B3/15 ,  A61B3/14 ,  A61B3/00 ,  A61B3/10

Abstract: An illumination system of an ophthalmologic apparatus of an exemplary embodiment projects illumination light from a light source onto the anterior eye segment of a subject's eye. An interference photographing system photographs an interference pattern formed on the cornea by the illumination light. An anterior eye segment photographing system photographs the anterior eye segment onto which the illumination light is being projected. A first optical path coupling element couples the optical path of the interference photographing system and the optical path of the anterior eye segment photographing system with one another. A controller controls a display device to display an observation interference image that is at least part of an interference image acquired by the interference photographing system and an anterior eye segment image acquired by the anterior eye segment photographing system together with each other, and controls the display device to display observation location information indicating a location of the observation interference image in the anterior eye segment image.

公开(公告)号：US20190259163A1

公开(公告)日：2019-08-22

申请号：US16277319

申请日：2019-02-15

Applicant: Topcon Corporation

Inventor： Zaixing Mao ,  Zhenguo Wang ,  Kinpui Chan ,  Yasufumi Fukuma

IPC: G06T7/136 ,  G06T7/12 ,  G06K9/36 ,  G06T7/00 ,  G06K9/62 ,  G06F17/18

Abstract: A machine learning model is trained to identify the texture difference between the different layers of a multilayer object. By training with data in full 3D space, the resulting model is capable of predicting the probability that each pixel in a 3D image belongs to a certain layer. With the resulting probability map, comparing probabilities allows one to determine boundaries between layers, and/or other properties and useful information such as volume data.

公开(公告)号：US11503995B2

公开(公告)日：2022-11-22

申请号：US16845747

申请日：2020-04-10

Applicant: Topcon Corporation

Inventor： Zhenguo Wang ,  Zaixing Mao ,  Kazuhiro Oomori ,  Makoto Fujino

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/15

Abstract: An ophthalmologic apparatus includes: an objective lens that faces a subject's eye; a first illumination optical system that irradiates a cornea of the subject's eye with illumination light; and a corneal measurement optical system having an imaging element that takes an image of a corneal reflection light, which is a reflection of the illumination light, through the objective lens, and outputs an imaging signal. The corneal measurement optical system includes a first mirror arranged near the objective lens and a second mirror arranged near the imaging element. The first and second mirrors and are configured such that the corneal reflection light that enters and is reflected from the first mirror, and then enters and is reflected from the second mirror exits toward an incident side from which the corneal reflection light enters a reflection surface of the first mirror.