公开(公告)号：US20070254892A1

公开(公告)日：2007-11-01

申请号：US11789548

申请日：2007-04-25

申请人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar 1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环 - 低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳族基团; R 2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R 3是氢原子或低级烷基; R 4是氢原子，卤素原子，羟基，低级烷基或-N（R 1）1个基团）的基团， SUP>; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US6090054A

公开(公告)日：2000-07-18

申请号：US97113

申请日：1998-06-12

申请人： Hiroyuki Tagishi ,  Toshihiro Sakamoto ,  Kazuyasu Ikadai

发明人： Hiroyuki Tagishi ,  Toshihiro Sakamoto ,  Kazuyasu Ikadai

IPC分类号： A61H23/02 ,  A61H1/00

CPC分类号： A61H23/0245 ,  A61H2201/0176

摘要： An improved ultrasonic wave cosmetic device which is able to protect skin against burns. The ultrasonic wave cosmetic device for treating skin includes a probe head having a skin contact metal surface for contacting the skin to transmit an ultrasonic wave thereto, an ultrasonic wave vibration element for vibrating at an ultrasonic wave frequency in response to an output signal from an ultrasonic wave oscillation circuit, and a temperature sensor mounted in a manner directly contacting a side surface of the ultrasonic wave vibration element and a surface opposite the skin contact metal surface for detecting the temperature of the probe head. The temperature sensor feeds back signals to the oscillation circuit which terminates the oscillation output signal when the probe head gets too hot.

摘要翻译： 一种改进的超声波化妆品，能够保护皮肤免受灼伤。 用于治疗皮肤的超声波化妆品装置包括具有皮肤接触金属表面的探针头，用于接触皮肤以传送超声波，超声波振动元件，响应于来自超声波的输出信号以超声波频率振动 波振荡电路和以与超声波振动元件的侧面直接接触的方式安装的温度传感器和与皮肤接触金属表面相对的表面，用于检测探头的温度。 温度传感器将信号反馈到振荡电路，当探针头太热时终止振荡输出信号。

公开(公告)号：US5502015A

公开(公告)日：1996-03-26

申请号：US389420

申请日：1995-02-16

申请人： Kenichiro Shibata ,  Akihito Fujii ,  Toshihiro Sakamoto

发明人： Kenichiro Shibata ,  Akihito Fujii ,  Toshihiro Sakamoto

IPC分类号： C04B35/553

CPC分类号： C04B35/553

摘要： The present invention provides an infrared ray transmitting material, even large-sized one being manufacturable at a low price, consisting of a polycrystal not liable to cleavage, which makes only a slight absorption of infrared rays all over the region of 8-11 .mu.m wave lengths, thus being highly transmissive. The material is a polycrystalline barium fluoride sintered body excellent in transmission to infrared region of 8-11 .mu.m wave lengths, one that is most excellent in the infrared transmission being produced by a method comprising the hot press sintering and the HIP treatment in combination, one that gives somewhat inferior transmission but which is low-priced by a method comprising the CIP molding and the normal pressure sintering in combination, and one that regarded as intermediate between the aforementioned two by a method comprising the CIP molding, normal-pressure sintering and the HIP treatment in combination, in all cases entirely without addition of any binder or sintering aid.

摘要翻译： 本发明提供一种红外线透射材料，即使是大尺寸的也可以以低价格制造，由不易裂开的多晶体组成，仅在8-11μm的区域内仅有轻微的红外线吸收 波长，因此是高度透射的。 该材料是通过包含热压烧结和HIP处理的方法制造的红外线透过率最高的8-11μm波长的透射率优异的多晶氟化钡烧结体， 通过包括CIP成型和常压烧结的方法组合的方法，通过包括CIP成型，常压烧结和 在所有情况下，组合的HIP处理完全不添加任何粘合剂或烧结助剂。

公开(公告)号：US08207169B2

公开(公告)日：2012-06-26

申请号：US12995832

申请日：2009-05-28

申请人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

发明人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

IPC分类号： A61K31/495

CPC分类号： C07D471/14

摘要： The compounds of Formula D are of the class of triazolo-pyrido-pyrazines which are inhibitors of AKT useful for the treatment of cancer

摘要翻译： 式D的化合物是三唑并 - 吡啶并吡嗪类，其是可用于治疗癌症的AKT抑制剂

公开(公告)号：US20110092511A1

公开(公告)日：2011-04-21

申请号：US12995832

申请日：2009-05-28

申请人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

发明人： Hidetomo Furuyama ,  Yasuhiro Goto ,  Nobuhiko Kawanishi ,  Mark E. Layton ,  Takashi Mita ,  Akira Naya ,  Yoshio Ogino ,  Yu Onozaki ,  Kevin J. Rodzinak ,  Toshihiro Sakamoto ,  Philip E. Sanderson ,  Jiabing Wang

IPC分类号： A61K31/4985 ,  C07D471/14 ,  A61K31/4375 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D471/14

摘要： The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity especially Akt1 by administering the compound to a patient in need of treatment of cancer.

摘要翻译： 本发明提供抑制Akt活性的取代的萘啶化合物。 特别地，所公开的化合物选择性地抑制一种或两种Akt同种型，优选Akt1。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性，尤其是Akt1的方法。

公开(公告)号：US07834019B2

公开(公告)日：2010-11-16

申请号：US11789548

申请日：2007-04-25

申请人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/519 ,  A61K31/497 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US20100221211A1

公开(公告)日：2010-09-02

申请号：US12738885

申请日：2008-10-20

申请人： Hidetomo Furuyama ,  Mikako Kawamura ,  Toshihiro Sakamoto ,  Fuyuki Yamamoto ,  Takashi Yoshizumi

发明人： Hidetomo Furuyama ,  Mikako Kawamura ,  Toshihiro Sakamoto ,  Fuyuki Yamamoto ,  Takashi Yoshizumi

IPC分类号： A61K38/20 ,  C07D487/04 ,  A61K31/519 ,  A61K31/397 ,  A61K39/395 ,  A61K38/21 ,  A61K31/675 ,  A61K31/7028 ,  A61K31/52 ,  A61K31/7068 ,  A61K31/7076 ,  A61K38/12 ,  A61K31/704 ,  A61K31/7048 ,  A61K38/14 ,  A61K33/24 ,  A61K31/555 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/715 ,  A61K38/46 ,  A61K31/7056 ,  A61K31/5685 ,  A61K33/36 ,  A61K38/08 ,  A61P35/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  A61K2300/00

摘要： The invention relates to a compound of general formula (I-0): wherein R1 means a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, or a C3-C6 cycloalkyl group; R2, R3, R4 and R5 mean a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, or a halo-C1-C6 alkoxy group; R6 means a hydrogen atom, or a C1-C6 alkyl group; R7a means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6 alkyl group, -Q2-N(R1c)R1d or a nitrogen-containing heterocyclic group; R8a means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group or a hydroxy-C1-C6 alkyl group; or R7a and R8a form, as taken together, a C2-C6 alkylene group, or R7a and R8a and the ring atoms to which they bond may form a spiro ring or a bicyclo ring; and X and Y mean a methine group or a nitrogen atom.The compound of the invention has, based on its excellent Wee1 kinase-inhibitory effect, a cell growth-inhibitory effect and an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

摘要翻译： 本发明涉及通式（I-0）的化合物：其中R1表示C1-C6烷基，C2-C6烯基，C2-C6炔基或C3-C6环烷基; R2，R3，R4和R5表示氢原子，卤素原子，C1-C6烷基，卤代-C1-C6烷基，C1-C6烷氧基或卤代-C1-C6烷氧基; R6表示氢原子或C1-C6烷基; R7a表示氢原子，卤素原子，C1-C6烷基，卤代-C1-C6烷基，C1-C6烷氧基，羟基-C1-C6烷基，-Q2-N（R1c）R1d 或含氮杂环基; R8a表示氢原子，卤素原子，C1-C6烷基，卤代-C1-C6烷基，C1-C6烷氧基或羟基-C1-C6烷基; 或R 7a和R 8a一起形成C 2 -C 6亚烷基或R 7a和R 8a，并且它们键合的环原子可以形成螺环或双环; X和Y表示次甲基或氮原子。 本发明的化合物基于其优异的Wee1激酶抑制作用，具有细胞生长抑制作用和与任何其它抗癌剂的添加/协同效应，因此在医学领域是有用的。

公开(公告)号：US20100044618A1

公开(公告)日：2010-02-25

申请号：US12518498

申请日：2008-09-03

申请人： Tomoyuki Ishimine ,  Toshihiro Sakamoto ,  Toru Maeda ,  Naoto Igarashi

发明人： Tomoyuki Ishimine ,  Toshihiro Sakamoto ,  Toru Maeda ,  Naoto Igarashi

IPC分类号： H01F1/04 ,  B32B5/16 ,  B05D7/00 ,  B22F1/00 ,  B22F1/02 ,  B05D5/00

CPC分类号： H01F3/02 ,  B22F1/0014 ,  B22F1/0062 ,  B22F1/007 ,  B22F2999/00 ,  C22C38/00 ,  C22C2202/02 ,  H01F1/24 ,  H01F1/26 ,  H01F1/33 ,  H01F41/0246 ,  Y10T428/2982 ,  B22F3/10 ,  B22F2201/02

摘要： A soft magnetic material, a dust core, a method for manufacturing the soft magnetic material, and a method for manufacturing the dust core that can improve DC bias characteristics are provided.A soft magnetic material includes a plurality of metal magnetic particles 10 whose coefficient of variation Cv (σ/μ), which is a ratio of a standard deviation (σ) of a particle size of the metal magnetic particles 10 to an average particle size (μ) thereof, is 0.40 or less and whose circularity Sf is 0.80 or more and 1 or less. The metal magnetic particles 10 preferably have an average particle size of 1 μm or more and 70 μm or less. The soft magnetic material preferably further includes an insulating coated film that surrounds a surface of each of the metal magnetic particles 10.

摘要翻译： 提供软磁性材料，压粉芯，软磁性材料的制造方法以及可提高直流偏压特性的集尘芯的制造方法。 软磁性材料包括多个金属磁性颗粒10，其金属磁性颗粒10的粒径与平均颗粒的标准偏差（＆sgr）的比值变化系数Cv（＆Sgr /μ） 尺寸（μ）为0.40以下，圆形度Sf为0.80以上1以下。 金属磁性粒子10的平均粒径优选为1μm以上且70μm以下。 软磁性材料优选还包括围绕每个金属磁性颗粒10的表面的绝缘涂膜。

公开(公告)号：US20060147145A1

公开(公告)日：2006-07-06

申请号：US10527214

申请日：2003-09-10

申请人： Takashi Shinriki ,  Toshihiro Sakamoto ,  Masanao Kurihara ,  Toru Sugamata ,  Norikazu Miyazaki

发明人： Takashi Shinriki ,  Toshihiro Sakamoto ,  Masanao Kurihara ,  Toru Sugamata ,  Norikazu Miyazaki

IPC分类号： G02F1/035

CPC分类号： G02F1/0305 ,  G02F1/0316 ,  G02F1/225

摘要： An optical modulator in which stabilized driving is realized over a long time by relaxing stress generated in a recess formed in the surface of a substrate in the optical modulator and controlling deterioration of optical modulation control caused by stress-strain in the substrate including an optical waveguide. The optical modulator comprises a substrate of a material exhibiting electrooptic effect, an optical waveguide (4) provided on the substrate, and control electrodes (20-25) for controlling the phase of light being guided through the optical waveguide characterized in that a recess (12) is provided in the surface of the substrate for forming the control electrodes, and the control electrode (24) being formed on the recess is provided with a stress relaxing means.

摘要翻译： 一种光调制器，其特征在于，通过在形成于所述光调制器的基板的表面上形成的凹部中产生的应力，在长时间内实现稳定的驱动，并控制由包括光波导的基板中的应力应变引起的光调制控制的劣化 。 光学调制器包括具有电光效应的材料的衬底，设置在衬底上的光波导（4）和用于控制通过光波导引导的光的相位的控制电极（20-25），其特征在于，凹部 12）设置在用于形成控制电极的基板的表面中，并且形成在凹部上的控制电极（24）设置有应力缓和装置。

公开(公告)号：US06980705B2

公开(公告)日：2005-12-27

申请号：US10451435

申请日：2001-11-28

申请人： Yasuyuki Miyama ,  Hirotoshi Nagata ,  Toshihiro Sakamoto

发明人： Yasuyuki Miyama ,  Hirotoshi Nagata ,  Toshihiro Sakamoto

IPC分类号： G02B6/12 ,  G02F1/03 ,  G02F1/035

CPC分类号： G02F1/0322 ,  G02F1/035 ,  G02F1/0356 ,  G02F2201/07 ,  G02F2201/16 ,  G02F2203/21 ,  G02F2203/50

摘要： A first film (8) is formed between a substrate (1) and a signal electrode (3); ground electrodes (5) and (6) which constitute an optical waveguide device (10), and a second film (9) is formed between the substrate (1) and a signal electrode (4); ground electrodes (6) and (7). An optical phase modulator (10A) is composed of the substrate (1), an optical waveguide (2), the signal electrode (3), the ground electrodes (5) and (6), and the first film (8). An optical intensity modulator (10B) is composed of the substrate (1), the optical waveguide (2), the signal electrode (4), the ground electrodes (6) and (7), and the second film (9). The optical waveguide device (10) is composed of the optical phase modulator (10A) and the optical intensity modulator (10B), which are integrated monolithically.

摘要翻译： 第一膜（8）形成在基板（1）和信号电极（3）之间; 构成光波导装置（10）的接地电极（5）和（6），在基板（1）和信号电极（4）之间形成第二膜（9）。 接地电极（6）和（7）。 光学相位调制器（10A）由基片（1），光波导（2），信号电极（3），接地电极（5）和（6）和第一薄膜（8）构成。 光强度调制器（10 B）由基板（1），光波导（2），信号电极（4），接地电极（6）和（7）和第二膜（9）构成。 光波导装置（10）由光学相位调制器（10A）和光强度调制器（10B）组成，其被整体地集成。