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21.发明授权公开(公告)号：US08455533B2
公开(公告)日：2013-06-04
申请号：US13390538
申请日：2010-08-23
申请人： Tesfaye Biftu , Ping Chen , Danqing Feng , Xiaoxia Qian
发明人： Tesfaye Biftu , Ping Chen , Danqing Feng , Xiaoxia Qian
IPC分类号： A61K31/4162 , C07D231/00
CPC分类号： C07D487/04
摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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22.发明申请公开(公告)号：US20120149734A1
公开(公告)日：2012-06-14
申请号：US13390538
申请日：2010-08-23
申请人： Tesfaye Biftu , Ping Chen , Danqing Feng , Xiaoxia Qian
发明人： Tesfaye Biftu , Ping Chen , Danqing Feng , Xiaoxia Qian
IPC分类号： A61K31/4162 , A61P3/10 , A61K31/4439 , C07D487/04 , A61K31/41
CPC分类号： C07D487/04
摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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23.发明授权Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权氨基四氢吡喃作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病公开(公告)号：US08143289B2
公开(公告)日：2012-03-27
申请号：US12616831
申请日：2009-11-12
申请人： Tesfaye Biftu , Ping Chen , Jason M. Cox , Ann E. Weber
发明人： Tesfaye Biftu , Ping Chen , Jason M. Cox , Ann E. Weber
IPC分类号： A61K31/4439 , A61K31/4162 , A61P3/10 , C07D401/14 , C07D487/04
CPC分类号： C07D309/30 , A61K9/2054 , A61K31/4162 , A61K38/1709 , A61K38/26 , A61K45/06 , C07D487/04
摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及结构式I的新型取代的氨基四氢吡喃，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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24.发明授权Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权氨基四氢吡喃作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病公开(公告)号：US07678905B2
公开(公告)日：2010-03-16
申请号：US11728673
申请日：2007-03-27
申请人： Tesfaye Biftu , Ann E. Weber
发明人： Tesfaye Biftu , Ann E. Weber
IPC分类号： C07D251/00
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及结构式I的新型取代的氨基四氢吡喃，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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25.发明授权3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权3-氨基-4-苯基丁酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病公开(公告)号：US07560455B2
公开(公告)日：2009-07-14
申请号：US10556805
申请日：2004-05-10
IPC分类号： A61P3/10 , A61K31/55 , C07D491/00
CPC分类号： C07D487/04
摘要： The pre-sent invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 预先发明的发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的3-氨基-4-苯基丁酸衍生物，其可用于治疗或预防其中二肽基 涉及肽酶-IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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26.发明授权Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权氨基环己烷作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病公开(公告)号：US07482336B2
公开(公告)日：2009-01-27
申请号：US11628686
申请日：2005-06-17
申请人： Tesfaye Biftu , Danqing Feng , Ying-Duo Gao , Suresh Singh , Ann E. Weber
发明人： Tesfaye Biftu , Danqing Feng , Ying-Duo Gao , Suresh Singh , Ann E. Weber
IPC分类号： A01N43/00 , A01N43/58 , A01N43/60 , A01N43/90 , A01N43/38 , A61K31/00 , A61K31/50 , A61K31/495 , A61K31/519 , A61K31/40 , C07D243/00 , C07D471/00
CPC分类号： C07D487/04 , C07D209/44 , C07D243/08 , C07D471/04
摘要： The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的氨基环己烷，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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27.发明申请Aminocyclohexanes as Dipeptidyl Peptidase-Iv Inhibitors for the Treatment or Prevention of Diabetes 有权氨基环己烷作为二肽基肽酶-Iv抑制剂用于治疗或预防糖尿病公开(公告)号：US20070254865A1
公开(公告)日：2007-11-01
申请号：US11628686
申请日：2005-06-17
申请人： Tesfaye Biftu , Danqing Feng , Ying-Duo Gao , Suresh Singh , Ann Weber
发明人： Tesfaye Biftu , Danqing Feng , Ying-Duo Gao , Suresh Singh , Ann Weber
IPC分类号： A61K31/4985 , A61K31/4035 , A61K31/519 , A61K31/551 , A61P3/10 , C07D209/44 , C07D243/08 , C07D487/04
CPC分类号： C07D487/04 , C07D209/44 , C07D243/08 , C07D471/04
摘要： The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的氨基环己烷，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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公开(公告)号：US5326783A
公开(公告)日：1994-07-05
申请号：US4875
申请日：1993-01-19
申请人： Tesfaye Biftu , Chan-Hwa Kuo , Conrad Santini
发明人： Tesfaye Biftu , Chan-Hwa Kuo , Conrad Santini
IPC分类号： C07D493/08 , A61K31/335 , A61K31/365 , C07D319/04 , C07D405/06
CPC分类号： C07D493/08
摘要： This invention is directed to compounds of formula (I) which are novel C3- or C5-acyl sulfonamide, carboxamic acid or tetrazolyl analogs of the Zaragozic acids. These compounds inhibit the enzyme squalene synthase and are useful as cholesterol lowering agents. ##STR1##
摘要翻译： 本发明涉及式（I）的化合物，其是萨拉哥ic酸的新型C3-或C5-酰基磺酰胺，羧酰胺或四唑基类似物。 这些化合物抑制角鲨烯合酶，可用作胆固醇降低剂。 （一）
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29.发明授权
公开(公告)号：US4977146A
公开(公告)日：1990-12-11
申请号：US505712
申请日：1990-04-11
IPC分类号： A61K31/34 , A61K31/341 , A61K31/67 , A61P1/04 , A61P7/02 , A61P9/02 , A61P11/00 , A61P11/08 , A61P29/00 , A61P37/06 , A61P37/08 , C07D20060101 , C07D307/12 , C07F9/09 , C07F9/655
CPC分类号： C07D307/12
摘要： The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R.sup.4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group, Y is an alkyl or substituted alkyl group, R.sup.6 is an alkyl or a substituted alkyl group and the substituents at positions 3, 4 or 5 are acyclic.
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30.发明授权
公开(公告)号：US4757084A
公开(公告)日：1988-07-12
申请号：US776191
申请日：1985-09-13
申请人： Tesfaye Biftu
发明人： Tesfaye Biftu
IPC分类号： A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4433 , A61P11/00 , A61P29/00 , C07C45/72 , C07C45/78 , C07D333/00 , C07D333/16 , C07D333/56 , C07D333/62 , C07D409/04 , C07D333/12
CPC分类号： C07D409/04 , C07C45/72 , C07C45/78 , C07D333/16
摘要： Analogs of 2,5-Diaryl tetrahydrothiophenes which were substituted or unsubstituted on 3,4-positions were prepared.These compounds are found to be leukotriene inhibitors and potent and specific PAF (Platelet Activating Factor) antagonists. They are therefore useful in the treatment of various diseases or disorders mediated by the leukotriene and/or PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.
摘要翻译： 制备在3,4位上取代或未取代的2,5-二芳基四氢噻吩的类似物。 发现这些化合物是白三烯抑制剂和有效和特异性的PAF（血小板活化因子）拮抗剂。 因此，它们可用于治疗由白细胞三烯和/或PAF介导的各种疾病或病症，例如炎症，心血管疾病，哮喘，肺水肿，成人呼吸窘迫综合征，疼痛和血小板聚集。
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