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公开(公告)号：US20090286829A1
公开(公告)日：2009-11-19
申请号：US12436837
申请日：2009-05-07
IPC分类号： A61K31/4709 , A61P25/00
CPC分类号： A61K31/4709
摘要： Disclosed herein are methods for treating a disorder associated with selective subtype modulation of alpha 2B and alpha 2C adrenergic receptors. Such methods can be performed, for example, by administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount of at least one compound having the structure: Compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了治疗与α2B和α2C肾上腺素能受体的选择性亚型调节相关的病症的方法。 这样的方法可以例如通过向有需要的受试者施用含有治疗有效量的至少一种具有以下结构的化合物的药物组合物：还公开了与其有关的组合物和药物。
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公开(公告)号：US20110039866A1
公开(公告)日：2011-02-17
申请号：US12852768
申请日：2010-08-09
IPC分类号： A61K31/506 , C07D213/81 , A61K31/44 , A61K31/166 , C07C233/78 , C07D401/12 , A61P11/06 , A61P9/00 , A61P9/04 , A61P19/02 , A61P25/02 , A61P27/02
CPC分类号： C07D213/81 , C07D405/12 , C07D409/12
摘要： Described herein are compounds useful as antagonists of sphingosine-1-phosphate receptors. Further described herein is the use of these compounds and related pharmaceutical compositions to treat disorders associated with sphingosine-1-phosphate-3 (S1P3) receptor modulation.
摘要翻译： 本文描述的是可用作鞘氨醇-1-磷酸受体拮抗剂的化合物。 本文进一步描述的是这些化合物和相关药物组合物用于治疗与鞘氨醇-1-磷酸-3（S1P3）受体调节相关的病症的用途。
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公开(公告)号：US20100273814A1
公开(公告)日：2010-10-28
申请号：US12600191
申请日：2008-05-13
申请人： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
发明人： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
IPC分类号： A61K31/4439 , C07D401/06 , C07D403/06 , C07D409/06 , A61K31/506 , A61K31/4178 , A61P25/00
CPC分类号： C07D401/06 , C07D409/06
摘要： Disclosed herein is a compound of the formula wherein A and B are described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了下式的化合物，其中A和B在本文中描述。 还公开了与之相关的治疗方法，组合物和药物。
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公开(公告)号：US20090286842A1
公开(公告)日：2009-11-19
申请号：US12436839
申请日：2009-05-07
IPC分类号： A61K31/4164 , A61P13/00
CPC分类号： A61K31/4174
摘要： Disclosed herein is a method of treating stress urinary incontinence comprising administering a compound to a mammal in need thereof, wherein said compound has the formula Compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了一种治疗压力性尿失禁的方法，包括向有需要的哺乳动物施用化合物，其中所述化合物具有式其组合物和与之有关的药物也被公开。
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25.发明申请公开(公告)号：US20100190823A1
公开(公告)日：2010-07-29
申请号：US12600757
申请日：2008-05-21
申请人： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
发明人： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
IPC分类号： A61K31/4709 , C07D401/14 , C07D405/14 , A61K31/4439 , A61P29/00
CPC分类号： C07D409/12
摘要： Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（I）的化合物，还公开了与其相关的治疗方法，组合物和药物。
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公开(公告)号：US20100113516A1
公开(公告)日：2010-05-06
申请号：US12522887
申请日：2008-01-04
IPC分类号： A61K31/4709 , C07D401/08 , A61P27/06 , A61P27/02 , A61P29/00 , A61P11/02
CPC分类号： C07D401/06
摘要： Disclosed herein is a compound of the formula (I):(I). Therapeutic methods, compositions and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（I）的化合物：（I）。 还公开了与此相关的治疗方法，组合物和药物。
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公开(公告)号：US20090306398A1
公开(公告)日：2009-12-10
申请号：US12479256
申请日：2009-06-05
申请人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
发明人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
IPC分类号： C07D233/44
CPC分类号： A61K31/4168 , C07D233/48
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.
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28.发明授权公开(公告)号：US08383646B2
公开(公告)日：2013-02-26
申请号：US12600757
申请日：2008-05-21
申请人： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
发明人： Santosh C. Sinha , Todd M. Heidelbaugh , Ken Chow , Smita S. Bhat , Phong X. Nguyen , Michael E. Garst
IPC分类号： A61K31/47 , C07D401/14
CPC分类号： C07D409/12
摘要： Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（I）的化合物，还公开了与其相关的治疗方法，组合物和药物。
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29.发明授权N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds as subtype selective modulators of ALPHA2B or ALPHA2B and ALPHA2C adrenoceptors 失效作为ALPHA2B或ALPHA2B和ALPHA2C肾上腺素受体的亚型选择性调节剂的N-（1-苯基-2-芳基乙基）-4,5-二氢-2H-吡咯-5-胺化合物公开(公告)号：US08183414B2
公开(公告)日：2012-05-22
申请号：US12632494
申请日：2009-12-07
申请人： Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K Fang , Santosh C. Sinha , Michael E. Garst
发明人： Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K Fang , Santosh C. Sinha , Michael E. Garst
IPC分类号： C07C257/00 , A61K31/155
CPC分类号： C07D207/22 , C07D401/12
摘要： The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formula
摘要翻译： 本发明提供了N-（1-苯基-2-芳基乙基）-4,5-二氢-2H-吡咯-5-胺化合物的化合物，并且是α2B或α2B和α2C肾上腺素受体的亚型选择性调节剂，并且是 选自由式表示的化合物组
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公开(公告)号：US08063231B2
公开(公告)日：2011-11-22
申请号：US12479256
申请日：2009-06-05
申请人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
发明人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
IPC分类号： C07D233/48
CPC分类号： A61K31/4168 , C07D233/48
摘要： Described herein are novel N-(2 and/or 3-substituted benzyl)-4,5-dihydro-1H-imidazol-2-amine derivatives processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals modulators of subtype α2B and/or α2C adrenergic receptors.
摘要翻译： 本文描述的是新型的N-（2和/或3-取代的苄基）-4,5-二氢-1H-咪唑-2-胺衍生物的制备方法，含有它们的药物组合物及其作为α2B亚型的药物调节剂的用途 /或α2C肾上腺素能受体。
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