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1.发明授权公开(公告)号：US08809379B2
公开(公告)日：2014-08-19
申请号：US12353406
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Ling Li , Wenkui K. Fang , Janet A. Takeuchi , Smita Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Ling Li , Wenkui K. Fang , Janet A. Takeuchi , Smita Bhat
IPC分类号： A61K31/53 , A61K31/50 , A61K31/44 , A61K31/497 , A61K31/4439
CPC分类号： A61K31/4439 , A61K31/497
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了明确定义的杂环化合物，其可用作亚型选择性α2肾上腺素能激动剂。 因此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种疾病。
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2.发明授权公开(公告)号：US08735399B2
公开(公告)日：2014-05-27
申请号：US12863386
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
IPC分类号： A61K31/422 , A61K31/497 , C07D241/12 , C07D263/12 , C07D413/12 , C07D213/18
CPC分类号： C07D401/12 , A61K31/422 , A61K31/497 , C07D213/18 , C07D241/12 , C07D263/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides oxazolidine and thiazolidine derivatives that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供可用作亚型选择性α2肾上腺素能激动剂的恶唑烷和噻唑烷衍生物。 因此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种病症。
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3.发明申请3-(4-(5-PHENYL-1 ,2,4-OXADIAZOL-3-YL)PHENOXY)PROPAN-2-OL DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 有权3-（4-（5-苯基-1,2,4-氧杂唑-3-基）苯氧基）丙-2-醇衍生物作为SPHINGOSINE-1磷酸酯受体调节剂公开(公告)号：US20130065860A1
公开(公告)日：2013-03-14
申请号：US13604152
申请日：2012-09-05
申请人： Janet A. Takeuchi , Ling Li , Ken Chow
发明人： Janet A. Takeuchi , Ling Li , Ken Chow
IPC分类号： C07F9/653 , A61K31/4245 , A61K31/675 , A61P37/00 , A61P19/02 , A61P9/10 , A61P17/06 , A61P17/00 , A61P25/00 , A61P37/06 , A61P27/04 , A61P1/00 , C07D271/06 , A61P37/08
CPC分类号： A61K31/4245 , C07D271/06 , C07F9/65318
摘要： The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及新的恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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4.发明申请3-(4-((1H-IMIDAZOL-1-YL)METHYL)PHENYL)-5-ARYL-1,2,4-OXADIAZOLE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 有权3-（4 - （（1H-咪唑-1-基）甲基）苯基）-5-亚芳基-1,2,4-氧杂噻唑衍生物作为SPHINGOSINE-1磷酸酯受体调节剂公开(公告)号：US20120302606A1
公开(公告)日：2012-11-29
申请号：US13567654
申请日：2012-08-06
申请人： Janet A. Takeuchi , Ken Chow , Ling Li
发明人： Janet A. Takeuchi , Ken Chow , Ling Li
IPC分类号： A61K31/4245 , A61P37/00 , A61K31/454 , C07D413/10 , C07D413/14
CPC分类号： C07D413/10
摘要： Substituted 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-phenyl-1,2,4-oxadiazole derivatives which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 取代的3-（4 - （（1H-咪唑-1-基）甲基）苯基）-5-苯基-1,2,4-恶二唑衍生物，其可用作鞘氨醇-1-磷酸调节剂并且可用于治疗多种 的与调节鞘氨醇-1-磷酸受体相关的疾病。
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5.发明申请SUBSTITUTED BICYCLIC METHYL AZETIDINES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS 失效作为SPHINGOSINE-1磷酸酯受体调节剂的取代的双环亚甲基公开(公告)号：US20120264730A1
公开(公告)日：2012-10-18
申请号：US13442023
申请日：2012-04-09
申请人： Janet A. Takeuchi , Ling Li , Wha Bin Im
发明人： Janet A. Takeuchi , Ling Li , Wha Bin Im
IPC分类号： A61K31/4709 , A61P27/02 , A61P27/06 , A61P29/00 , A61P9/00 , A61P11/00 , A61P7/00 , A61P35/04 , A61P9/10 , A61P37/06 , A61P1/00 , A61P25/00 , A61P17/06 , A61P13/12 , A61P17/00 , A61P37/08 , A61P11/06 , A61P19/10 , A61P25/28 , C07D401/10
CPC分类号： C07D401/06 , A61K31/4709 , A61K45/06 , C07D215/14
摘要： The present invention relates to novel substituted bicyclic methyl azetidine derivatives which are useful as sphingosine-1-phosphate receptors modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及可用作鞘氨醇-1-磷酸受体调节剂并可用于治疗与调节鞘氨醇-1-磷酸受体相关的多种病症的新型取代的双环甲基氮杂环丁烷衍生物。
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6.发明申请SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF 失效选择性亚型ALPHA 2 ADRENERGIC AGENTS及其使用方法公开(公告)号：US20110034517A1
公开(公告)日：2011-02-10
申请号：US12811773
申请日：2009-01-14
申请人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
发明人： Todd M. Heidelbaugh , Ken Chow , Santosh C. Sinha , Phong X. Nguyen , Wenkui K. Fang , Ling Li , Janet A. Takeuchi , Smita S. Bhat
IPC分类号： A61K31/4439 , C07D413/12 , C07D417/12 , C07D401/12 , A61P25/28 , A61P1/00 , A61P25/00 , A61P3/10 , A61P25/18
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了明确定义的杂环化合物，其可用作亚型选择性α2肾上腺素能激动剂。 因此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节相关的多种病症。
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7.发明授权Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US07638648B2
公开(公告)日：2009-12-29
申请号：US11728313
申请日：2007-03-23
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Yin Tsang , Ling Li , Janet A. Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha A. Chandraratna
IPC分类号： C07D265/06 , C07D263/02 , C07D277/02 , C07D213/02 , C07D333/04 , C07D307/34 , C07C229/34
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 本说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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![7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity](/abs-image/US/2005/05/03/US06887896B1/abs.jpg.150x150.jpg)
8.发明授权7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity 失效7 - [（7-烷氧基） - 色烯-3-烯-6-基] - 庚三烯酸和具有血清葡萄糖降低的7 - [（3-烷氧基）-5,6-二氢萘-2-基] - 庚二酸衍生物 活动公开(公告)号：US06887896B1
公开(公告)日：2005-05-03
申请号：US10696748
申请日：2003-10-29
申请人： Richard L. Beard , Tien T. Duong , Janet A. Takeuchi , Ling Li , Kwok Yin Tsang , Xiaoxia Liu , Jayasree Vasudevan , Liming Wang , Santosh C. Sinha , Haiqing Yuan , Roshantha A. Chandraratna
发明人： Richard L. Beard , Tien T. Duong , Janet A. Takeuchi , Ling Li , Kwok Yin Tsang , Xiaoxia Liu , Jayasree Vasudevan , Liming Wang , Santosh C. Sinha , Haiqing Yuan , Roshantha A. Chandraratna
IPC分类号： A61K31/21 , A61K31/335 , C07C59/72 , C07C69/587 , C07C69/734 , C07D311/58 , A61K31/35 , A61K31/19 , A61K31/235
CPC分类号： C07C69/734 , C07C59/72 , C07C2601/02 , C07C2602/28 , C07D311/58
摘要： Compounds of the formula where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.
摘要翻译： 其中变化具有本说明书中定义的含义的式的化合物能够降低糖尿病哺乳动物中的血清葡萄糖水平，而没有暂时增加甘油三酯水平和降低血清甲状腺素水平的不良副作用。
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9.发明授权Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators 失效苯基双环甲胺衍生物作为鞘氨醇-1磷酸受体调节剂公开(公告)号：US08541582B2
公开(公告)日：2013-09-24
申请号：US13446352
申请日：2012-04-13
申请人： Janet A. Takeuchi , Ling Li , Wha Bin Im
发明人： Janet A. Takeuchi , Ling Li , Wha Bin Im
IPC分类号： C07D215/14 , C07F9/38 , C07F9/60
CPC分类号： A61K31/665 , A61K31/662 , C07D215/12 , C07F9/3808 , C07F9/3834 , C07F9/60 , C07F9/65517
摘要： The present invention relates to novel phenyl bicyclic methyl amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译： 本发明涉及新的苯基二环甲基胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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10.发明申请AROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHONATE (S1P) RECEPTOR ACTIVITY 失效具有丝氨酸1-磷酸（S1P）受体活性的芳香化合物公开(公告)号：US20130018019A1
公开(公告)日：2013-01-17
申请号：US13569243
申请日：2012-08-08
申请人： Janet A. Takeuchi , Ling Li , Xiaoxia Liu
发明人： Janet A. Takeuchi , Ling Li , Xiaoxia Liu
IPC分类号： A61K31/675 , A61K31/661 , A61P29/00 , A61P19/02 , A61P37/06 , A61P9/00 , A61P27/02 , A61P1/00 , A61P17/00 , A61P25/00 , A61K31/662 , A61P17/06
CPC分类号： C07F9/3808 , C07F9/5355 , C07F9/572 , C07F9/58 , C07F9/65583 , C07F9/65586
摘要： Novel aromatic compounds which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.
摘要翻译： 可用作鞘氨醇-1-磷酸调节剂的新型芳族化合物，可用于治疗与调节鞘氨醇-1-磷酸受体相关的各种疾病。
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