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42 条记录 (耗时 0.032 秒)

    1-alkyl ergolinylthiourea derivatives and their use as antidepressant agents
    22.
    发明授权
    1-alkyl ergolinylthiourea derivatives and their use as antidepressant agents 失效
    1-烷基麦角酰硫基脲衍生物及其作为抗抑郁药的用途

    公开(公告)号：US4772610A

    公开(公告)日：1988-09-20

    申请号：US893727

    申请日：1986-08-06

    申请人： Helmut Biere ,  Gerhard Sauer ,  Helmut Wachtel

    发明人： Helmut Biere ,  Gerhard Sauer ,  Helmut Wachtel

    IPC分类号： A61K31/48 ,  A61P25/02 ,  A61P25/24 ,  A61P25/26 ,  C07D457/12

    CPC分类号： C07D457/12

    摘要： Novel 1-alkyl ergolinylthiourea derivatives of the general formula ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl,R.sup.2 and R.sup.3 are C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.1-4 alkyl andC.sub.9---- C.sub.10 is a single bond or a double bond,and the acid addition salts thereof, with the provision that when R.sup.3 and R.sup.4 are both ethyl, R.sup.1 and R.sup.2 are not methyl and acid addition salts thereof are provided; as well as a process for the preparation of these compounds. The compounds are useful as medicinal agents, e.g., for the treatment of mental depression.

    摘要翻译： 新颖的通式为：其中R 1为C 1-6烷基，R 2和R 3为C 1-4烷基，R 4为氢或C 1-4烷基，C 9 -C 10为单键或双键的1-烷基麦角酰硫基脲衍生物 键和其酸加成盐，条件是当R 3和R 4都是乙基时，R 1和R 2不是甲基，并且提供其酸加成盐; 以及制备这些化合物的方法。 这些化合物可用作药物，例如用于治疗精神抑郁症。

    2-substituted ergolines
    25.
    发明授权
    2-substituted ergolines 失效
    2-取代的麦角碱

    公开(公告)号：US5158957A

    公开(公告)日：1992-10-27

    申请号：US720996

    申请日：1991-06-26

    申请人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    发明人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    IPC分类号： A61K31/48 ,  A61P25/00 ,  A61P43/00 ,  C07D457/12

    CPC分类号： C07D457/12

    摘要： 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single of double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 --CHR.sup.9 --COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.

    摘要翻译： 2-取代的ergolines 其中C2 C3和C9 C10表示单键的双键; X是氧或硫; R 2是C 1-10烷基，任选被卤素取代的C 2-10烯基，CH 2 YR 3，CR 12（OR 4）R 5，CH 2 -CHR 9 -CON 10或COR 12，其中Y是氧或硫，R 3是氢，C 1-4烷基，苯基， C2-5酰基或苯基C1-4烷基，R4是氢或C2-5酰基，R5是C1-9烷基，R9是COCH3或COO-C1-4烷基，R10是C1-4烷基或O-C1-4 烷基，R 12是氢或C 1-19烷基; 并且R 6是C 2-10烷基，C 3-10烯基或C 4-10环烷基-C 1-3烷基，其酸加成盐，异构体和异构体混合物是多巴胺能激动剂，可用于治疗帕金森病。

    2-substituted ergolines
    26.
    发明授权
    2-substituted ergolines 失效
    2-取代的麦角碱

    公开(公告)号：US5037832A

    公开(公告)日：1991-08-06

    申请号：US380352

    申请日：1989-07-17

    申请人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    发明人： Thomas Brumby ,  Gerhard Sauer ,  Josef Heindl ,  Jonathan Turner ,  Gerhard Kuhne ,  Helmut Wachtel

    IPC分类号： A61K31/48 ,  A61P25/00 ,  A61P43/00 ,  C07D457/12

    CPC分类号： C07D457/12

    摘要： 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single or double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 -CHR.sup.9 -COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.

    摘要翻译： 2-取代的麦角糖苷其中C2 C3和C9 C10表示单键或双键; X是氧或硫; R 2是C 1-10烷基，任选被卤素取代的C 2-10烯基，CH 2 YR 3，CR 12（OR 4）R 5，CH 2 -CHR 9 -CON 10或COR 12，其中Y是氧或硫，R 3是氢，C 1-4烷基，苯基， C2-5酰基或苯基C1-4烷基，R4是氢或C2-5酰基，R5是C1-9烷基，R9是COCH3或COO-C1-4烷基，R10是C1-4烷基或O-C1-4 烷基，R 12是氢或C 1-19烷基; 并且R 6是C 2-10烷基，C 3-10烯基或C 4-10环烷基-C 1-3烷基，其酸加成盐，异构体和异构体混合物是多巴胺能激动剂，可用于治疗帕金森病。