公开(公告)号：US09173811B2

公开(公告)日：2015-11-03

申请号：US13630522

申请日：2012-09-28

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/05 ,  A61H39/00 ,  A61N1/375 ,  A61N1/36 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36096 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An implantable electroacupuncture device (IEAD) treats mental illness through application of stimulation pulses applied at a specified tissue location, including at least one of acupoints GV20 and EXHN3, or their underlying nerves. In one embodiment, the IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在指定组织位置施加的刺激脉冲来治疗精神疾病，包括至少一个穴位GV20和EXHN3或其潜在的神经。 在一个实施例中，IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214118A1

公开(公告)日：2014-07-31

申请号：US13630522

申请日：2012-09-28

Applicant: VALENCIA TECHNOLOGIES CORPORATION

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00

CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36096 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An implantable electroacupuncture device (IEAD) treats mental illness through application of stimulation pulses applied at a specified tissue location, including at least one of acupoints GV20 and EXHN3, or their underlying nerves. In one embodiment, the IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在指定组织位置施加的刺激脉冲来治疗精神疾病，包括至少一个穴位GV20和EXHN3或其潜在的神经。 在一个实施例中，IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20190290541A1

公开(公告)日：2019-09-26

申请号：US16392378

申请日：2019-04-23

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/372 ,  A61N1/36 ,  A61N1/375

Abstract: A method of treating a mental disorder of a patient includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a tissue location associated with the mental disorder. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US20190247274A1

公开(公告)日：2019-08-15

申请号：US16394902

申请日：2019-04-25

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61H39/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/375

CPC classification number: A61H39/002 ,  A61H39/00 ,  A61H2201/01 ,  A61N1/3606 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3782 ,  A61N1/3787 ,  Y10T29/49002

Abstract: A method of treating cardiovascular disease in a patient includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a tissue location associated with the cardiovascular disease. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US09827134B2

公开(公告)日：2017-11-28

申请号：US14799492

申请日：2015-07-14

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy Greiner Chambliss

IPC: A61N1/00 ,  A61F5/41 ,  A61H39/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/362 ,  A61N1/375 ,  A61N1/18 ,  A61N1/378

CPC classification number: A61F5/41 ,  A61F2005/418 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61H2205/087 ,  A61N1/18 ,  A61N1/36107 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD includes an IEAD housing having an electrode configuration thereon that includes at least two electrodes, and pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes. The pulse generation circuitry is adapted to deliver EA stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, the stimulation regimen requiring that the stimulation session have a duration of T3 minutes and a rate of occurrence of once every T4 minutes, and wherein a ratio of T3/T4 is no greater than 0.05.

公开(公告)号：US20170135898A1

公开(公告)日：2017-05-18

申请号：US15421294

申请日：2017-01-31

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy Greiner Chambliss

IPC: A61H39/00 ,  A61F5/00 ,  A61N1/372 ,  A61N1/375 ,  A61N1/378 ,  A61N1/36

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of a saphenous nerve and a peroneal nerve of the patient by way of an electrode array located within the patient at an acupoint corresponding to at least one of the saphenous nerve and the peroneal nerve.

公开(公告)号：US09433788B2

公开(公告)日：2016-09-06

申请号：US14669155

申请日：2015-03-26

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/372 ,  A61H39/00 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61H39/00 ,  A61H2201/01 ,  A61N1/3606 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3782 ,  A61N1/3787 ,  Y10T29/49002

Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats cardiovascular disease through application of stimulation pulses applied at at least one of acupoints EX-HN1, BL14, HT7, HT5, PC6, ST36, LI11, LU7, and LU2. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位EX-HN1，BL14，HT7，HT5，PC6，ST36，LI11，LU7和LU2中的至少一个上施加的刺激脉冲来治疗心血管疾病。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低功耗周期和精细的电源管理可以使IEAD在几年内完成其预期功能。

公开(公告)号：US09327134B2

公开(公告)日：2016-05-03

申请号：US13796314

申请日：2013-03-12

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/00 ,  A61N1/375 ,  A61N1/36 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61N1/36067 ,  A61N1/36096 ,  A61N1/36107 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  H01L2224/48091 ,  Y10T29/49002 ,  H01L2924/00014

Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在目标组织位置（例如穴位）上施加的电针（EA）刺激脉冲来治疗患者的医疗状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生EA刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US09198828B2

公开(公告)日：2015-12-01

申请号：US13630322

申请日：2012-09-28

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/05 ,  A61H39/00 ,  A61N1/36 ,  A61N1/375 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61N1/36096 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats depression, bipolar disorder or Anxiety through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3处施加的刺激脉冲来治疗抑郁症，双相情感障碍或焦虑症。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20150321007A1

公开(公告)日：2015-11-12

申请号：US14805355

申请日：2015-07-21

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/05

CPC classification number: A61N1/0504 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3605 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10S128/907

Abstract: A method of treating hypertension in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a target tissue location within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location by way of the central electrode and the annular electrode in accordance with the duty cycle.

Abstract translation: 一种治疗患者的高血压的方法包括：通过植入患者皮肤表面下方的针刺装置，在对应于患者内的目标组织位置的穴位，产生小于0.05的占空比的刺激会话， 其特征在于，所述占空比为T3〜T4的比例，所述刺激对象中包含的每个刺激对象具有T3分钟的持续时间，以T4分钟为单位的速度发生，所述电针装置包括第一极性的中心电极， 第二极性的环形电极，与中心电极间隔开; 以及2）通过电针装置根据占空比通过中心电极和环形电极施加刺激会话到目标组织位置。