公开(公告)号：US20240350805A1

公开(公告)日：2024-10-24

申请号：US18684796

申请日：2022-08-25

申请人： VANDERBILT UNIVERSITY

发明人： David T. Kent

IPC分类号： A61N1/36

CPC分类号： A61N1/3611 ,  A61N1/3601 ,  A61N1/36139 ,  A61N1/36175

摘要： The present disclosure relates to systems and methods for improving sleep disordered breathing by stimulating the ansa cervicalis and activating the sternothyroid muscle and stimulating the phrenic nerve to activate the diaphragm.

公开(公告)号：US12109416B2

公开(公告)日：2024-10-08

申请号：US17156896

申请日：2021-01-25

申请人： Barologics, Inc.

发明人： Dimitrios Georgakopoulos ,  Molly Wade

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/282 ,  A61B5/021 ,  A61B5/024

CPC分类号： A61N1/36053 ,  A61B5/0006 ,  A61B5/0205 ,  A61B5/282 ,  A61N1/36057 ,  A61N1/36117 ,  A61N1/36135 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178 ,  A61B5/02108 ,  A61B5/024

摘要： A method for stimulating nerve fibers to treat a condition in a patient first involves identifying carotid sinus nerve afferent fibers in a first side of the patient's neck and identifying cardiac-specific vagal nerve afferent fibers in the first side of the patient's neck. The method further involves placing a first multipolar electrode device around the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers. Finally, the method involves stimulating the carotid sinus nerve afferent fibers and the cardiac-specific vagal nerve afferent fibers, using the first multipolar electrode device. This method may be performed on a second side of the neck as well.

公开(公告)号：US20240307693A1

公开(公告)日：2024-09-19

申请号：US18598460

申请日：2024-03-07

申请人： Boston Scientific Neuromodulation Corporation

发明人： Mahsa Malekmohammadi ,  Richard Mustakos ,  Stephen Carcieri

IPC分类号： A61N1/36 ,  A61N1/05 ,  G16H20/40

CPC分类号： A61N1/36175 ,  A61N1/0534 ,  G16H20/40

摘要： This document discusses neurostimulation devices, systems, and methods. A neurostimulation system receives a physiological target region for the neurostimulation and one or more optimization criteria for the neurostimulation of the target region. The neurostimulation system determines a likelihood of finding a stimulation configuration solution using a first optimization algorithm according to the physiological target region, determines a likelihood that the stimulation configuration solution is a better solution than what would be found by a second optimization algorithm and selects the first optimization algorithm or the second optimization algorithm according to the determined likelihood. The neurostimulation system recurrently changes stimulation parameters according to the selected optimization algorithm to determine the stimulation configuration solution based on the one or more optimization criteria and presenting the stimulation configuration solution to a user.

公开(公告)号：US20240307681A1

公开(公告)日：2024-09-19

申请号：US18672957

申请日：2024-05-23

申请人： Wisconsin Alumni Research Foundation ,  Mayo Foundation for Medical Education and Research

发明人： Justin Williams ,  Kip Ludwig ,  Erika Ross

IPC分类号： A61N1/05 ,  A61N1/04 ,  A61N1/36 ,  A61N1/375

CPC分类号： A61N1/056 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/0536 ,  A61N1/0551 ,  A61N1/36025 ,  A61N1/36034 ,  A61N1/36053 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/36175 ,  A61N1/37516

摘要： The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.

公开(公告)号：US12090322B2

公开(公告)日：2024-09-17

申请号：US17443172

申请日：2021-07-21

申请人： Wavegate Corporation

发明人： Erich W. Wolf, II

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36062 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178

摘要： The Randomized Intermittent Dichotomous Stimulation (RIDS) paradigm disclosed provides an alternate stimulus for the patient to attend to, besides the typical SCS signal, thus providing a somatotopically-matched non-noxious stimulus to replace the cognitive attention to the nociceptive stimulus. The randomly intermittent stimulus is paired with an implicit virtual task to reinforce selective attention to the non-noxious stimulus.

公开(公告)号：US20240293675A1

公开(公告)日：2024-09-05

申请号：US18646403

申请日：2024-04-25

申请人： Boston Scientific Neuromodulation Corporation

发明人： James R. Kozloski ,  Anup Kalia ,  Jeffrey Rogers ,  Sara E. Berger

IPC分类号： A61N1/36 ,  A61N1/02 ,  G16H20/40

CPC分类号： A61N1/36132 ,  A61N1/025 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/36175 ,  A61N1/36189 ,  G16H20/40

摘要： Systems and techniques are disclosed to establish programming of an implantable electrical neurostimulation device for treating pain of a human subject, through the use and adjustment of analgesic stimulation parameters based on trust dynamics and trust measurements. In an example, the system to establish programming of the neurostimulation device performs operations that: determine a trust measurement value that is derived from results of at least one commitment made with a human subject, via observable interactions; determine a modification of at least one neurostimulation programming parameter, based on the trust measurement value; and to cause the implantable neurostimulation device to implement the modification of the at least one neurostimulation programming parameter. Further examples are provided to produce and track the trust measurement value, as well as identify a pain susceptibility value and determine a receptiveness to analgesic effects based on these and other trust dynamics.

公开(公告)号：US12064635B2

公开(公告)日：2024-08-20

申请号：US17081752

申请日：2020-10-27

申请人： Boston Scientific Neuromodulation Corporation

发明人： Tianhe Zhang ,  Changfang Zhu ,  Que T. Doan

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC分类号： A61N1/36164 ,  A61N1/0551 ,  A61N1/36062 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36139 ,  A61N1/36185 ,  A61N1/36189 ,  A61N1/37247 ,  A61N1/3615 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178

摘要： An example of a system to program a neuromodulator to deliver neuromodulation to a neural target using a plurality of electrodes may comprise a programming control circuit configured to determine target energy allocations for the plurality of electrodes based on at least one target pole to provide a target sub-perception modulation field, and normalize the target sub-perception modulation field, including determine a time domain scaling factor to account for at least one property of a neural target or of a neuromodulation waveform, and apply the time domain scaling factor to the target energy allocations.

公开(公告)号：US20240252831A1

公开(公告)日：2024-08-01

申请号：US18629438

申请日：2024-04-08

申请人： Boston Scientific Neuromodulation Corporation

发明人： Michael A. Moffitt

IPC分类号： A61N1/372 ,  A61N1/05 ,  A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36135 ,  A61N1/36175 ,  A61N1/36185

摘要： A neurostimulation system configured for providing neurostimulation therapy to a patient. A user customizes a pulse pattern on a pulse-by-pulse basis. Electrical stimulation energy is delivered to at least one electrode in accordance with the customized pulse pattern.

公开(公告)号：US12011596B2

公开(公告)日：2024-06-18

申请号：US17397502

申请日：2021-08-09

申请人： Medtronic, Inc.

发明人： Lisa M. Johanek

IPC分类号： A61N1/00 ,  A61N1/36

CPC分类号： A61N1/36071 ,  A61N1/36062 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178 ,  A61N1/36007 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36107

摘要： In some examples, a medical device is configured to deliver high dose electrical stimulation therapy to a patient by at least generating and delivering an electrical stimulation signal having a relatively high duty cycle, and a stimulation intensity less than a perception or paresthesia threshold intensity level for the patient. The pulses may each have a relatively low amplitude, but due at least in part to a relatively high number of pulses per unit of time, the electrical stimulation signal may be high enough to elicit a therapeutic response from the patient. In some examples, the plurality of pulses may have a duty cycle in a range of about 5% to about 50%. Following the generation and delivery of the plurality of pulses, one or more recharge pulses for the plurality of pulses may be delivered.

公开(公告)号：US20240181260A1

公开(公告)日：2024-06-06

申请号：US18491267

申请日：2023-10-20

申请人： Advanced Neuromodulation Systems, Inc.

发明人： Michael Fortner

IPC分类号： A61N1/36 ,  A61N1/02 ,  A61N1/05 ,  A61N1/06

CPC分类号： A61N1/36139 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/06 ,  A61N1/36062 ,  A61N1/36071 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178

摘要： An implantable medical device (IMD) configured to sense biosignals of a patient. The IMD comprises one or more power components for powering the IPG and sensing circuitry for sensing one or more biosignals of the patient, wherein the sensing circuitry comprises a hybrid circuit having a BJT portion and a CMOS FET portion, the BJT portion configured to amplify low voltage signals with low equivalent noise and the CMOS FET portion forming a power-optimized output stage.