公开(公告)号：US20160206507A1

公开(公告)日：2016-07-21

申请号：US15084362

申请日：2016-03-29

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/372 ,  A61N1/375 ,  A61N1/36

CPC classification number: A61H39/002 ,  A61N1/36067 ,  A61N1/36096 ,  A61N1/36107 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  H01L2224/48091 ,  Y10T29/49002 ,  H01L2924/00014

Abstract: An electroacupuncture device includes 1) a housing configured to be implanted beneath a skin surface of the patient at an acupoint within the patient, 2) a central electrode centrally located on a first surface of the housing, 3) an annular electrode that surrounds the central electrode on the first surface of the housing, the annular electrode being spaced apart from the central electrode, and 4) pulse generation circuitry located within the housing, wherein the pulse generation circuitry generates stimulation sessions at a duty cycle that is less than 0.05 and applies the stimulation sessions at the acupoint by way of the central electrode and the annular electrode in accordance with the duty cycle.

Abstract translation: 电针装置包括：1）壳体，其被配置成植入在患者的穴位下方的患者皮肤表面下方，2）居中地位于所述外壳的第一表面上的中心电极，3）围绕所述中心的环形电极 电极在壳体的第一表面上，环形电极与中心电极间隔开，以及4）位于壳体内的脉冲发生电路，其中脉冲发生电路以小于0.05的占空比产生刺激会话并应用 根据占空比通过中心电极和环形电极在穴位处的刺激会话。

公开(公告)号：US20160008221A1

公开(公告)日：2016-01-14

申请号：US14859098

申请日：2015-09-18

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/375 ,  A61N1/36

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to at least one of a saphenous nerve and a peroneal nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of the saphenous nerve and the peroneal nerve by way of a central electrode and an annular electrode located on a housing of the electroacupuncture device.

Abstract translation: 一种治疗患者肥胖或血脂异常的示例性方法包括：通过植入患者皮肤表面下方的针刺装置产生对应于患者的隐神经和腓神经中的至少一个的穴位，刺激会话 在小于0.05的占空比下，以及2）通过电针装置根据占空比将刺激会话通过中心电极和环形的至少一个隐神经和腓神经施加 电极位于电针装置的壳体上。

公开(公告)号：US20160008220A1

公开(公告)日：2016-01-14

申请号：US14859088

申请日：2015-09-18

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/36 ,  A61N1/375 ,  A61F5/00

CPC classification number: A61H39/002 ,  A61F5/0026 ,  A61H2201/50 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36085 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An exemplary method of treating obesity or dyslipidemia of a patient using a small implantable electroacupuncture device (IEAD) includes 1) implanting the IEAD below the skin surface of the patient at or near a target tissue location selected from the group of target tissue locations comprising acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, LR8 and their underlying nerves, the saphenous nerve and the peroneal nerve, and 2) enabling the IEAD to provide EA stimulation pulses in accordance with a stimulation regimen that provides a stimulation session having a duration of T3 minutes at a rate of once every T4 minutes, where the ratio of T3/T4 is no greater than 0.05, and wherein T3 is at least 10 minutes and no greater than 60 minutes.

Abstract translation: 使用小型可植入电针装置（IEAD）治疗患者的肥胖症或血脂异常的示例性方法包括：1）在选自包括穴位的目标组织位置组的靶组织位置处或附近将患者的皮肤表面植入患者的皮肤表面 ST36，SP4，ST37，ST40，SP6，SP9，K16，LR8及其潜在的神经，隐神经和腓神经，以及2）使IEAD能够根据提供刺激疗程的刺激方案提供EA刺激脉冲 以T3 / T4比不大于0.05的速度每T4分钟一次持续T3分钟，其中T3至少为10分钟且不大于60分钟。

公开(公告)号：US09173811B2

公开(公告)日：2015-11-03

申请号：US13630522

申请日：2012-09-28

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/05 ,  A61H39/00 ,  A61N1/375 ,  A61N1/36 ,  A61N1/372 ,  A61N1/378

CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36096 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An implantable electroacupuncture device (IEAD) treats mental illness through application of stimulation pulses applied at a specified tissue location, including at least one of acupoints GV20 and EXHN3, or their underlying nerves. In one embodiment, the IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在指定组织位置施加的刺激脉冲来治疗精神疾病，包括至少一个穴位GV20和EXHN3或其潜在的神经。 在一个实施例中，IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214118A1

公开(公告)日：2014-07-31

申请号：US13630522

申请日：2012-09-28

Applicant: VALENCIA TECHNOLOGIES CORPORATION

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00

CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36096 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An implantable electroacupuncture device (IEAD) treats mental illness through application of stimulation pulses applied at a specified tissue location, including at least one of acupoints GV20 and EXHN3, or their underlying nerves. In one embodiment, the IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在指定组织位置施加的刺激脉冲来治疗精神疾病，包括至少一个穴位GV20和EXHN3或其潜在的神经。 在一个实施例中，IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US11478403B2

公开(公告)日：2022-10-25

申请号：US16392378

申请日：2019-04-23

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/375 ,  A61N1/36 ,  A61N1/372 ,  A61N1/378

Abstract: A method of treating a mental disorder of a patient includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a tissue location associated with the mental disorder. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US20190247275A1

公开(公告)日：2019-08-15

申请号：US16394932

申请日：2019-04-25

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61F5/00 ,  A61N1/36 ,  A61N1/375 ,  A61N1/378 ,  A61N1/372

Abstract: A method comprises generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a patient. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US20150313750A1

公开(公告)日：2015-11-05

申请号：US14799492

申请日：2015-07-14

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61F5/41 ,  A61N1/36

CPC classification number: A61F5/41 ,  A61F2005/418 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61H2205/087 ,  A61N1/18 ,  A61N1/36107 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD includes an IEAD housing having an electrode configuration thereon that includes at least two electrodes, and pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes. The pulse generation circuitry is adapted to deliver EA stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, the stimulation regimen requiring that the stimulation session have a duration of T3 minutes and a rate of occurrence of once every T4 minutes, and wherein a ratio of T3/T4 is no greater than 0.05.

Abstract translation: 可植入电针装置（IEAD）通过施加施加在穴位BL52，BL23或GV4中的至少一个穴位下方或附近的目标组织位置处的刺激脉冲来治疗患者的勃起功能障碍状况。 IEAD包括其上具有电极配置的IEAD外壳，其包括至少两个电极，以及位于IEAD外壳内并电耦合到至少两个电极的脉冲发生电路。 脉冲发生电路适于根据指定的刺激方案将EA刺激脉冲输送到目标组织位置处或附近的患者身体组织，刺激方案要求刺激疗程具有T3分钟的持续时间和出现发生率 每T4分钟一次，其中T3 / T4的比例不大于0.05。

公开(公告)号：US08942816B2

公开(公告)日：2015-01-27

申请号：US13736041

申请日：2013-01-07

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/05 ,  A61H39/00

CPC classification number: A61H39/002 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/3606 ,  A61N1/36085 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats dyslipidemia conditions of a patient through application of stimulation pulses applied at acupoint ST40, or its underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位ST40施加的刺激脉冲或其潜伏的隐神经和腓神经来治疗患者的血脂异常状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214126A1

公开(公告)日：2014-07-31

申请号：US13736039

申请日：2013-01-07

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00

CPC classification number: A61H39/002 ,  A61H2201/01 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61N1/32 ,  A61N1/36085 ,  A61N1/36089 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49208

Abstract: An implantable electroacupuncture device (IEAD) treats obese conditions of a patient through application of stimulation pulses applied at acupoints SP4, LR8 or ST40, or their underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位SP4，LR8或ST40上施加的刺激脉冲或其潜伏的隐神经和腓神经来治疗患者的肥胖状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。