摘要:
The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
摘要:
This document provides methods and materials related to detecting premalignant or malignant neoplasms (e.g., colorectal and pancreatic cancer). For example, methods and materials for assessing the contents of phagocytes for the presence of one or more biological markers (e.g., Alu repeats or methylated nucleic acid) of premalignant or malignant neoplasms are provided.
摘要:
This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided.
摘要:
The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.
摘要:
A method for compiling a mapping between a source schema and a target schema is provided. The method comprises multiple passes, including determining source node dependencies, matching hierarchy, and generating code. The method may further comprise initializing node dependency memory prior to determining source node dependencies, and freeing node dependency memory after code generation. The compiler algorithm provides for compiling user-defined functions in the mapping into the compiled representation. Another aspect of the invention provides for generating an XSL code representation of the mapping. An XSL style sheet representation may thus be generated from a visual mapping in accordance with the invention.
摘要:
A motion responsive alarm system including a motion sensor having a housing with a rotatable disk therein, a slot in the disk and a ball bearing in the slot and being loosely confined within an annular chamber in the housing surrounding the disk. The disk contains a plurality of orifices which pass between an LED on one side of the disk and a phototransistor on the other. A signal from the phototransistor is sent to a triggering circuit by interrupting light transfer between the LED and the phototransistor. The circuit includes a novel oscillator having a duty cycle of 10% which drives the LED in the sensor. An alternate state device is coupled to the sensor and the oscillator for generating alternate state outputs only during sensing of motion. A one-shot circuit generates a motion pulse each time motion is sensed. A pulse interval timer and gate determine if the pulses are to be gated to a timer or blocked. The timer is reset by these pulses and does not generate an alarm unless a predetermined period of time passes. The device may be coupled to a self-contained breathing apparatus and is energized only when the breathing apparatus mask is being worn by the user.
摘要:
An apparatus for intersystem I/O channel paging. The I/O channel through an I/O channel adapter provides communication between a central processor, an I/O processor, and a shared electronic storage device. The central processor and I/O processor are each enabled for recognizing specific instructions. The intersystem channel may be implemented in the form of a page chain table. Either process is capable of constructing a page chain table in the shared electronic storage device, upon receipt of appropriate instructions. The central processor or I/O processor signals the I/O channel adapter with identification of a page chain table to select. The I/O channel adapter fetches table entries and executes the table. The I/O channel adapter initiates I/O activity upon execution of the table. The I/O channel is not dependent upon the central processor or I/O processor for fetching or executing instructions, rather it acts independent of the processors once the page chain table is created. Flags set in the table serve as a disconnection mechanism for the I/O channel paging system. The I/O channel paging mechanism may operate synchronously or asynchronously.
摘要翻译:用于系统间I / O通道寻呼的装置。 通过I / O通道适配器的I / O通道提供中央处理器,I / O处理器和共享电子存储设备之间的通信。 每个中央处理器和I / O处理器均可用于识别特定的指令。 系统间通道可以以页链表的形式来实现。 任何一个进程都能够在收到适当的指令后在共享电子存储设备中构建页链表。 中央处理器或I / O处理器向I / O通道适配器发送信号以识别页链表进行选择。 I / O通道适配器提取表条目并执行表。 I / O通道适配器在执行表时启动I / O活动。 I / O通道不依赖于用于获取或执行指令的中央处理器或I / O处理器,而是在创建页链表之后独立于处理器。 表中设置的标志用作I / O通道寻呼系统的断开机制。 I / O通道寻呼机制可以同步或异步地进行。
摘要:
This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
摘要:
Embodiments of the invention provide techniques for processing a database query that allows data values for attributes of a child database record to be inherited from an associated parent record. A hierarchical query function may automatically determine the inheritance of attribute values in queries of hierarchical data. In the case that a query does not retrieve values for all attributes specified in the query, the missing attribute values are determined from higher levels of the hierarchy.