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    REDUCING IRF4, DUSP22, OR FLJ43663 POLYPEPTIDE EXPRESSION
    4.
    发明申请
    REDUCING IRF4, DUSP22, OR FLJ43663 POLYPEPTIDE EXPRESSION 审中-公开
    减少IRF4，DUSP22或FLJ43663多肽表达

    公开(公告)号：US20100324119A1

    公开(公告)日：2010-12-23

    申请号：US12782484

    申请日：2010-05-18

    申请人： Andrew L. Feldman ,  Ahmet Dogan ,  George Vasmatzis ,  Mark Law ,  David I. Smith

    发明人： Andrew L. Feldman ,  Ahmet Dogan ,  George Vasmatzis ,  Mark Law ,  David I. Smith

    IPC分类号： A61K31/713 ,  C12Q1/68 ,  G01N33/68 ,  A61P35/00

    CPC分类号： A61K31/713 ,  G01N33/57407 ,  G01N2333/4703

    摘要： This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.

    摘要翻译： 本文件涉及干扰素调节因子4（IRF4）在T细胞淋巴瘤中的活性。 例如，提供了涉及减少T细胞淋巴瘤细胞中的IRF4多肽的表达的方法和材料，以及鉴定具有减少T细胞淋巴瘤细胞中的IRF4多肽表达的能力的试剂。 本文还涉及减少T细胞淋巴瘤中的DUSP22或FLJ43663多肽活性。 例如，提供涉及降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽的表达的方法和材料，以及具有降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽表达的能力的鉴定试剂 。

    Polynucleotide probe and kit for amplifying signal detection in hybridization assays
    5.
    发明授权
    Polynucleotide probe and kit for amplifying signal detection in hybridization assays 失效
    用于在杂交测定中扩增信号检测的多核苷酸探针和试剂盒

    公开(公告)号：US06306657B1

    公开(公告)日：2001-10-23

    申请号：US08719476

    申请日：1996-09-25

    申请人： Sithian Pandian ,  Eng Jom Aw ,  David I. Smith

    发明人： Sithian Pandian ,  Eng Jom Aw ,  David I. Smith

    IPC分类号： G01N3100

    CPC分类号： C12Q1/682 ,  Y02A50/59

    摘要： The present invention provides a method for simplifying and significantly enhancing the sensitivity of nucleic acid hybridization assays. A method is described whereby a single-stranded primary nucleic acid sequence that includes a region of sequences complementary to a single-stranded target nucleic acid sequence is hybridized to the target molecule. Stability of the double-stranded complex thereby formed can be enhanced by using RNA as the probe if DNA is the target or DNA as the probe if RNA is the target. The probe-target complex is subsequently immunocaptured for detection. After washing away extraneous material, a secondary nucleic acid sequence containing many repeating sequence units is hybridized to the probe component of the immobilized probe-target complex. Detection occurs following hybridization of many labelled nucleic acid sequence probes to each of the repeating sequence units of a nucleic acid amplification probe. Thus, attachment of multiple labelling probes to an amplification probe that is hybridized to an immobilized probe-target complex, provides a simplified method for amplifying the detection signal and therefore the sensitivity of nucleic acid hybridization assays.

    摘要翻译： 本发明提供了简化并显着增强核酸杂交测定的灵敏度的方法。 描述了一种方法，其中包括与单链靶核酸序列互补的序列区域的单链初级核酸序列与靶分子杂交。 如果RNA是靶，则通过使用RNA作为探针，如果RNA是靶，则可以增强如此形成的双链复合物的稳定性。 探针 - 目标复合物随后被免疫捕获用于检测。 洗去外来物质后，含有许多重复序列单元的次级核酸序列与固定化的探针 - 目标复合物的探针组分杂交。 在许多标记的核酸序列探针杂交到核酸扩增探针的每个重复序列单元之后发生检测。 因此，将多个标记探针连接到与固定的探针 - 靶复合物杂交的扩增探针，提供了扩增检测信号并因此扩增核酸杂交测定的灵敏度的简化方法。

    REDUCING IRF4, DUSP22, OR FLJ43663 POLYPEPTIDE EXPRESSION
    7.
    发明申请
    REDUCING IRF4, DUSP22, OR FLJ43663 POLYPEPTIDE EXPRESSION 失效
    减少IRF4，DUSP22或FLJ43663多肽表达

    公开(公告)号：US20110306517A1

    公开(公告)日：2011-12-15

    申请号：US13213390

    申请日：2011-08-19

    申请人： Andrew L. Feldman ,  Ahmet Dogan ,  George Vasmatzis ,  Mark Law ,  David I. Smith

    发明人： Andrew L. Feldman ,  Ahmet Dogan ,  George Vasmatzis ,  Mark Law ,  David I. Smith

    IPC分类号： C40B30/04 ,  C12Q1/42 ,  G01N33/573 ,  C12Q1/68

    CPC分类号： A61K31/713 ,  G01N33/57407 ,  G01N2333/4703

    摘要： This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.

    摘要翻译： 本文件涉及干扰素调节因子4（IRF4）在T细胞淋巴瘤中的活性。 例如，提供了涉及减少T细胞淋巴瘤细胞中的IRF4多肽的表达的方法和材料，以及鉴定具有减少T细胞淋巴瘤细胞中的IRF4多肽表达的能力的试剂。 本文还涉及减少T细胞淋巴瘤中的DUSP22或FLJ43663多肽活性。 例如，提供涉及降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽的表达的方法和材料，以及具有降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽表达的能力的鉴定试剂 。

    Reducing IRF4, DUSP22, or FLJ43663 polypeptide expression
    10.
    发明授权
    Reducing IRF4, DUSP22, or FLJ43663 polypeptide expression 失效
    减少IRF4，DUSP22或FLJ43663多肽表达

    公开(公告)号：US08679743B2

    公开(公告)日：2014-03-25

    申请号：US13213390

    申请日：2011-08-19

    申请人： Andrew L. Feldman ,  Ahmet Dogan ,  George Vasmatzis ,  Mark Law ,  David I. Smith

    发明人： Andrew L. Feldman ,  Ahmet Dogan ,  George Vasmatzis ,  Mark Law ,  David I. Smith

    IPC分类号： C12Q1/68

    CPC分类号： A61K31/713 ,  G01N33/57407 ,  G01N2333/4703

    摘要： This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided.

    摘要翻译： 本文件涉及干扰素调节因子4（IRF4）在T细胞淋巴瘤中的活性。 例如，提供了涉及减少T细胞淋巴瘤细胞中的IRF4多肽的表达的方法和材料，以及鉴定具有减少T细胞淋巴瘤细胞中的IRF4多肽表达的能力的试剂。 本文还涉及减少T细胞淋巴瘤中的DUSP22或FLJ43663多肽活性。 例如，提供涉及降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽的表达的方法和材料，以及具有降低T细胞淋巴瘤细胞中DUSP22多肽和/或FLJ43663多肽表达的能力的鉴定试剂 。