公开(公告)号：US11472890B2

公开(公告)日：2022-10-18

申请号：US16805453

申请日：2020-02-28

Applicant: Xencor, Inc.

Inventor： Rumana Rashid ,  Umesh S. Muchhal ,  Gregory Moore ,  Alex Nisthal ,  Seung Chu ,  Sung-Hyung Lee ,  Yoon Kyung Kim

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/46 ,  C12N15/63

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

公开(公告)号：US20220162313A1

公开(公告)日：2022-05-26

申请号：US17542341

申请日：2021-12-03

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Rumana Rashid ,  Sung-Hyung Lee ,  Paul Foster

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2)

公开(公告)号：US10913803B2

公开(公告)日：2021-02-09

申请号：US15945679

申请日：2018-04-04

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/30 ,  C07K16/46 ,  C07K16/28 ,  A61K39/00

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20190352416A1

公开(公告)日：2019-11-21

申请号：US16530946

申请日：2019-08-02

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Sung-Hyung Lee

IPC: C07K16/28

Abstract: Provided herein are trispecific antibodies that include a) a first monomer, b) a second monomer, and c) a light chain. The first monomer includes a first variant Fc domain and a variable heavy domain, the second monomer includes a second variant Fc domain and a first scFv domain and the light chain includes a variable light domain. The variable heavy domain and the variable light domain form an antigen binding domain. The trispecific antibody further includes a second scFv domain on either the first or second monomers.

公开(公告)号：US20190202938A1

公开(公告)日：2019-07-04

申请号：US16354058

申请日：2019-03-14

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20180223000A1

公开(公告)日：2018-08-09

申请号：US15945681

申请日：2018-04-04

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20180118827A1

公开(公告)日：2018-05-03

申请号：US15636590

申请日：2017-06-28

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Rumana Rashid ,  Sung-Hyung Lee ,  Paul Foster

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2809 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2869 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2)

公开(公告)号：US20170081420A1

公开(公告)日：2017-03-23

申请号：US15185958

申请日：2016-06-17

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/30 ,  C07K16/28 ,  C07K16/46

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20240400675A1

公开(公告)日：2024-12-05

申请号：US18810362

申请日：2024-08-20

Applicant: Xencor, Inc.

Inventor： Matthew S. Faber ,  Sung-Hyung Lee ,  Yoon Kyung Kim ,  Jing Qi ,  Kendra N. Avery ,  Seung Y. Chu ,  Alex Nisthal ,  Matthew J. Bernett ,  John R. Desjarlais ,  Chad Borchert

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46 ,  C12N15/63

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

公开(公告)号：US20240228608A9

公开(公告)日：2024-07-11

申请号：US18348244

申请日：2023-07-06

Applicant: Xencor, Inc.

Inventor： Matthew S. Faber ,  Sung-Hyung Lee ,  Yoon Kyung Kim ,  Jing Qi ,  Kendra N. Avery ,  Seung Y. Chu ,  Alex Nisthal ,  Matthew J. Bernett ,  John R. Desjarlais ,  Chad Borchert

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46 ,  C12N15/63

CPC classification number: C07K16/28 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/468 ,  C12N15/63

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.