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235 条记录 (耗时 0.03 秒)

    Benzamide derivatives
    21.
    发明授权
    Benzamide derivatives 失效
    苯甲酰胺衍生物

    公开(公告)号：US5395832A

    公开(公告)日：1995-03-07

    申请号：US104095

    申请日：1993-08-11

    申请人： Yasuo Ito ,  Hideo Kato ,  Shingo Yasuda ,  Nobuhiko Iwasaki ,  Hiroyuki Nishino ,  Makoto Takeshita

    发明人： Yasuo Ito ,  Hideo Kato ,  Shingo Yasuda ,  Nobuhiko Iwasaki ,  Hiroyuki Nishino ,  Makoto Takeshita

    IPC分类号： C07D211/58 ,  C07D451/04 ,  C07D451/14 ,  A61K31/46 ,  A61K31/44

    CPC分类号： C07D451/04 ,  C07D211/58 ,  C07D451/14

    摘要： A benzamide derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkanoyl group; R.sup.2 represents a hydrogen atom or a halogen atom; R.sup.3 represents a lower alkoxy group; R.sup.4 represents a hydrogen atom or a lower alkyl group; R.sup.5 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; A represents C.sub.1 -C.sub.7 alkylene group which may optionally be substituted with a lower alkyl group; X represents a methylene group, an oxygen atom, or a sulfur atom; m represents an integer of from 0 to 3; n represents an integer of from 0 to 3; and p represents an integer of from 0 to 2 and a pharmacologically acceptable salt thereof is provided. These compounds are useful since they have gastrointestinal stimulating activity, and a pharmaceutical composition comprising said compound is useful for the treatment of gastrointestinal diseases.

    摘要翻译： PCT No.PCT / JP92 / 00134 Sec。 371日期：1993年8月11日 102（e）日期1993年8月11日PCT提交1992年2月12日PCT公布。 公开号WO92 / 14705 日本9月3日，1992。一种苯甲酰胺衍生物，由下式表示：其中R1表示氢原子或低级烷酰基; R2表示氢原子或卤素原子; R3表示低级烷氧基; R4代表氢原子或低级烷基; R5表示氢原子，低级烷基或低级烷氧基; A表示可以被低级烷基取代的C1-C7亚烷基; X表示亚甲基，氧原子或硫原子; m表示0〜3的整数， n表示0〜3的整数， p表示0〜2的整数，并且其药理学上可接受的盐。 这些化合物是有用的，因为它们具有胃肠道刺激活性，并且包含所述化合物的药物组合物可用于治疗胃肠道疾病。

    Anti-spasmodic substituted quinolizidine and indolizidine compounds
    24.
    发明授权
    Anti-spasmodic substituted quinolizidine and indolizidine compounds 失效
    抗痉挛性取代喹嗪啶和吲哚嗪类化合物

    公开(公告)号：US4205074A

    公开(公告)日：1980-05-27

    申请号：US16515

    申请日：1979-03-01

    申请人： Hideo Kato ,  Eiichi Koshinaka

    发明人： Hideo Kato ,  Eiichi Koshinaka

    IPC分类号： C07D455/02 ,  C07D471/04 ,  A61K31/445

    CPC分类号： C07D471/04 ,  C07D455/02

    摘要： Phenyl- or thienyl-substituted quinolizidines and indolizidines as well as quaternary salts thereof are disclosed. These compounds are useful as pharmaceutical agents exhibiting strong spasmolytic, anti-ulcer, anti-histaminic and antiemetic activities with minimized side effects such as thirst and dilation of the pupil.Phenyl- or thienyl-substituted quinolizidine-methanols and indolizidine-methanols which are starting materials of the aforementioned quinolizidine and indolizidine compounds are also useful as having spasmolytic, anti-ulcer, anti-histaminic and anti-emetic activities.

    摘要翻译： 公开了苯基或噻吩基取代的喹嗪基和吲哚嗪及其季盐。 这些化合物可用作具有强的解痉，抗溃疡，抗组胺和止吐活性的药物，其最小化的副作用如瞳孔的口渴和扩张。 作为上述喹嗪基和吲哚嗪化合物的起始原料的苯基或噻吩基取代的喹嗪基 - 甲醇和吲哚来啶 - 甲醇也可用作具有解痉，抗溃疡，抗组胺和抗呕吐活性。

    1',4'-Dihydro-1-methyl-spiro [piperidine and pyrrolidine-2,3'(2'H)quinoline]-2'-one compounds
    29.
    发明授权
    1',4'-Dihydro-1-methyl-spiro [piperidine and pyrrolidine-2,3'(2'H)quinoline]-2'-one compounds 失效
    1 {40,4 {40-二氢-1-甲基 - 螺（8）哌啶和吡咯烷-2,3（40（2（40H））喹啉{9-2 {

    公开(公告)号：US3936459A

    公开(公告)日：1976-02-03

    申请号：US531452

    申请日：1974-12-11

    申请人： Hideo Kato ,  Eiichi Koshinaka

    发明人： Hideo Kato ,  Eiichi Koshinaka

    IPC分类号： C07D471/10 ,  C07D215/38 ,  C07D215/22

    CPC分类号： C07D471/10

    摘要： Spiro compounds having the structural formula ##SPC1##Where n is an integer of 1 or 2,Are disclosed. These compounds are useful as analgetic, antihistamine and spasmolytic agents. They are indicated in the management of conditions such as headache, seasonal allergies and the like.

    摘要翻译： 螺旋化合物具有结构式，其中N为1或2的整数，被披露。 这些化合物可用作止痛药，抗组胺药和解痉药。 它们在诸如头痛，季节性过敏等条件的管理中被指出。

    1H-imidazopyridine derivatives
    30.
    发明授权
    1H-imidazopyridine derivatives 失效
    1H-咪唑并吡啶衍生物

    公开(公告)号：US06518265B1

    公开(公告)日：2003-02-11

    申请号：US09744959

    申请日：2001-05-02

    申请人： Hideo Kato ,  Jun Sakaguchi ,  Makoto Aoyama ,  Tomoyuki Izumi ,  Ken-ichi Kato

    发明人： Hideo Kato ,  Jun Sakaguchi ,  Makoto Aoyama ,  Tomoyuki Izumi ,  Ken-ichi Kato

    IPC分类号： A61K3154

    CPC分类号： C07D471/04

    摘要： 1H-Imidazopyridine derivatives represented by the following general formula or salts thereof: wherein R1 represents hydrogen atom, hydroxyl group, an alkyl group, a cycloalkyl group, styryl group, or an aryl group; R2 represents hydrogen atom, an alkyl group, a halogen atom, hydroxyl group, amino group, a cyclic amino group, or phenoxy group; ring A represents a homocyclic or heterocyclic ring which may be substituted; R3 represents a saturated nitrogen-containing heterocyclic group; and m represents an integer of from 0 to 3. The derivatives have excellent inhibitory actions against production of TNF or IL-1 and are extremely useful as preventive or therapeutic agents for diseases in which a cytokine is mediated.

    摘要翻译： 由以下通式表示的1H-咪唑并吡啶衍生物或其盐：其中R1表示氢原子，羟基，烷基，环烷基，苯乙烯基或芳基; R2表示氢原子，烷基，卤素原子，羟基，氨基，环状氨基或苯氧基; 环A表示可以被取代的杂环或杂环; R3表示饱和含氮杂环基; m表示0〜3的整数。该衍生物对TNF或IL-1的产生具有优异的抑制作用，作为介导细胞因子的疾病的预防或治疗剂是非常有用的。