公开(公告)号：US06518265B1

公开(公告)日：2003-02-11

申请号：US09744959

申请日：2001-05-02

申请人： Hideo Kato ,  Jun Sakaguchi ,  Makoto Aoyama ,  Tomoyuki Izumi ,  Ken-ichi Kato

发明人： Hideo Kato ,  Jun Sakaguchi ,  Makoto Aoyama ,  Tomoyuki Izumi ,  Ken-ichi Kato

IPC分类号： A61K3154

CPC分类号： C07D471/04

摘要： 1H-Imidazopyridine derivatives represented by the following general formula or salts thereof: wherein R1 represents hydrogen atom, hydroxyl group, an alkyl group, a cycloalkyl group, styryl group, or an aryl group; R2 represents hydrogen atom, an alkyl group, a halogen atom, hydroxyl group, amino group, a cyclic amino group, or phenoxy group; ring A represents a homocyclic or heterocyclic ring which may be substituted; R3 represents a saturated nitrogen-containing heterocyclic group; and m represents an integer of from 0 to 3. The derivatives have excellent inhibitory actions against production of TNF or IL-1 and are extremely useful as preventive or therapeutic agents for diseases in which a cytokine is mediated.

摘要翻译： 由以下通式表示的1H-咪唑并吡啶衍生物或其盐：其中R1表示氢原子，羟基，烷基，环烷基，苯乙烯基或芳基; R2表示氢原子，烷基，卤素原子，羟基，氨基，环状氨基或苯氧基; 环A表示可以被取代的杂环或杂环; R3表示饱和含氮杂环基; m表示0〜3的整数。该衍生物对TNF或IL-1的产生具有优异的抑制作用，作为介导细胞因子的疾病的预防或治疗剂是非常有用的。

公开(公告)号：US5153207A

公开(公告)日：1992-10-06

申请号：US520064

申请日：1990-05-03

申请人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

发明人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

IPC分类号： C07D211/46 ,  C07D211/54

CPC分类号： C07D211/54 ,  C07D211/46

摘要： A piperidine derivative represented by the following general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

公开(公告)号：US4983633A

公开(公告)日：1991-01-08

申请号：US241028

申请日：1988-09-02

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

IPC分类号： A61K31/165 ,  C07C233/12 ,  C07C233/73 ,  C07C235/48 ,  C07C311/15 ,  C07D295/08 ,  C07D295/092 ,  C07D317/68

CPC分类号： C07D295/088 ,  C07C255/00 ,  C07D317/68

摘要： Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.

公开(公告)号：US5095022A

公开(公告)日：1992-03-10

申请号：US538085

申请日：1990-06-13

申请人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

发明人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

IPC分类号： C07D211/70 ,  C07D405/04

CPC分类号： C07D405/04 ,  C07D211/70

摘要： A piperidine derivative represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; X represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--; Y represents an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represented an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

公开(公告)号：US06638951B1

公开(公告)日：2003-10-28

申请号：US09869338

申请日：2001-11-08

申请人： Hideo Kato ,  Noriyuki Kado ,  Jun Sakaguchi

发明人： Hideo Kato ,  Noriyuki Kado ,  Jun Sakaguchi

IPC分类号： A61K31445

CPC分类号： C07D211/58

摘要： A novel benzamide derivative represented by the following general formula: wherein R represents an alkyl group having 3 to 6 carbon atoms or a salt thereof, and a medicament comprising said derivative as an active ingredient. The medicament has excellent enhancing action on gastrointestinal tract motility, and is orally available with reduced side effects. Therefore, the medicament is extremely useful as an agent for therapeutic treatment of digestive diseases, an agent for improving function of gastrointestinal tract motility and the like.

摘要翻译： 由以下通式表示的新型苯甲酰胺衍生物：其中R表示碳原子数为3〜6的烷基或其盐，以及包含所述衍生物作为有效成分的药物。 该药物对胃肠道运动性具有优异的增强作用，口服可获得副作用降低。 因此，作为消化系统疾病的治疗用药剂，改善胃肠道运动功能的药剂等，药物是非常有用的。

公开(公告)号：US20120026471A1

公开(公告)日：2012-02-02

申请号：US13171205

申请日：2011-06-28

申请人： Jun Sakaguchi ,  Syunsuke Ono

发明人： Jun Sakaguchi ,  Syunsuke Ono

IPC分类号： G03B21/14 ,  H05B41/231

CPC分类号： G03B21/14 ,  G03B21/2013 ,  G03B21/2026 ,  G03B21/206

摘要： The projector uses two lamps, which are high-pressure discharge lamps with the same rated power, as light sources. The projector includes: a first alternating-current generator configured to generate a lamp current to be supplied to one of the lamps, based on an input control signal; a second alternating-current generator configured to generate a lamp current to be supplied to the other lamp, based on an input control signal; and a controller configured to control the lamp currents to have a same period and to be out of phase, by inputting a control signal to each of the first and the second alternating-current generators.

摘要翻译： 投影机使用两个灯，它们是具有相同额定功率的高压放电灯，如光源。 投影机包括：第一交流发电机，被配置为基于输入控制信号产生要提供给一个灯的灯电流; 第二交流发电机，其被配置为基于输入控制信号产生要提供给另一个灯的灯电流; 以及控制器，其被配置为通过向第一和第二交流发电机中的每一个输入控制信号来控制灯电流具有相同的周期并且相位差。

公开(公告)号：US08952611B2

公开(公告)日：2015-02-10

申请号：US13260898

申请日：2011-03-04

申请人： Jun Sakaguchi ,  Yoshiki Kitahara ,  Katsuhiro Ono ,  Kazunori Ohta

发明人： Jun Sakaguchi ,  Yoshiki Kitahara ,  Katsuhiro Ono ,  Kazunori Ohta

IPC分类号： H01J17/20 ,  H01J61/073 ,  G03B21/14 ,  G03B21/20 ,  H01J9/02

CPC分类号： H01J61/0735 ,  G03B21/14 ,  G03B21/20 ,  G03B21/2026 ,  G03B21/2086 ,  H01J9/02 ,  H01J61/0732

摘要： The present invention aims to prevent breakage of a sealing part and an electrode of a high pressure discharge lamp, and provides an electrode 100 used for a discharge lamp and having a rod-shaped part 101, one end of the rod-shaped part 101 to be sealed by a sealing part of an arc tube of the discharge lamp, the other end of the rod-shaped part 101 to be in a discharge space in the arc tube, wherein the rod-shaped part 101 has a rough surface that is composed of a plurality of types of crystal grains each having a different surface condition due to differences in crystal orientation.

摘要翻译： 本发明旨在防止高压放电灯的密封部分和电极的破裂，并且提供用于放电灯的电极100，并且具有棒状部分101，杆状部分101的一端至 由放电灯的电弧管的密封部分密封，棒状部101的另一端处于电弧管的放电空间中，其中，棒状部101具有粗糙面， 的多种类型的晶粒，其由于晶体取向的差异而具有不同的表面状态。

公开(公告)号：US20100231872A1

公开(公告)日：2010-09-16

申请号：US12438040

申请日：2007-06-08

申请人： Yoshiki Kitahara ,  Katsuhiro Ono ,  Jun Sakaguchi ,  Ryo Minamihata

发明人： Yoshiki Kitahara ,  Katsuhiro Ono ,  Jun Sakaguchi ,  Ryo Minamihata

IPC分类号： G03B21/20 ,  H01J61/36 ,  F21V7/07 ,  H01J9/26

CPC分类号： H01J9/326 ,  G03B21/2026 ,  G03B21/2086 ,  H01J61/36 ,  H01J61/366 ,  H01J61/86

摘要： The present invention is directed to a method for manufacturing a high-pressure discharge lamp including: a spherical portion forming a light-emitting portion (1a); sealing portions that are connected with both ends of the spherical portion; an electrode (2a) that is sealed to each of the sealing portions; and a metal foil (3a) that is connected with a rear end of each electrode. A vessel provided with a cylindrical glass tube (8) on both ends of the spherical portion is used, a connection structure of the metal foil and the electrode are disposed in the glass tube such that a front end of the electrode is positioned in the spherical portion, and the glass tube is melted by heat and shrunk for sealing the metal foil and the electrode so as to form the sealing portion. An inner diameter φ of the glass tube before the heat-melt processing and a distance L from an edge of the metal foil to the internal space of the spherical portion are set to satisfy a relationship of L/φ≧1.35, a corner of an edge portion of the metal foil on a side of the connection with the electrode is cut so as to form a wedge shape (7a), and subsequently the sealing step is performed. Thereby, it can suppress the generation of the breakage during the lighting life span, which is caused by a gap generated from the metal foil to an axis of the electrode during the sealing processing of the high-pressure discharge lamp having a high brightness property.

摘要翻译： 本发明涉及一种制造高压放电灯的方法，包括：形成发光部分（1a）的球形部分; 与球形部分的两端连接的密封部分; 对每个密封部分密封的电极（2a）; 和与各电极的后端连接的金属箔（3a）。 使用在球形部分的两端设置有圆柱形玻璃管（8）的容器，金属箔和电极的连接结构设置在玻璃管中，使得电极的前端位于球形 部分，并且玻璃管通过热熔化并收缩以密封金属箔和电极，以形成密封部分。 内径＆phgr 在熔融加工之前的玻璃管的距离L和从金属箔的边缘到球形部分的内部空间的距离L被设定为满足L /＆phgr;≥1.35的关系， 切断与电极连接侧的金属箔，形成楔形（7a），随后进行密封工序。 由此，能够抑制由于在具有高亮度特性的高压放电灯的密封处理期间由金属箔与电极的轴线产生的间隙引起的照明寿命期间的断裂的产生。

公开(公告)号：US20100188855A1

公开(公告)日：2010-07-29

申请号：US12668949

申请日：2008-07-14

申请人： Jun Sakaguchi ,  Yoshiki Kitahara ,  Katsuhiro Ono

发明人： Jun Sakaguchi ,  Yoshiki Kitahara ,  Katsuhiro Ono

IPC分类号： F21V7/00 ,  H01J61/36

CPC分类号： H01J61/368 ,  G03B21/2026 ,  H01J61/0732 ,  H01J61/86

摘要： A short arc high-pressure discharge lamp has an arc tube 1 made of quartz glass including a light-emitting portion 2 that fills mercury inside thereof and has a pair of electrodes arranged so as to face each other, and a sealing portion 3 connected to the light-emitting portion. The pair of electrodes have an electrode bar 5a, one end of the electrode bar is located in an internal space of the light-emitting portion, and the other end of the electrode bar is embedded in the sealing portion and bonded to a conductive metal-foil 7 sealed in the sealing portion. In at least a part of a portion of the electrode bar embedded in the sealing portion, the entire outer peripheral surface thereof is covered tightly with a metal-foil sleeve 7a. A high efficiency and high quality lamp is obtained in which fracture in the sealing portion of the arc tube caused by an ultrahigh vapor pressure in the tube surely is suppressed over the lifetime of the lamp, and the vapor pressure in the arc tube is elevated up to 30 MPa or more.

摘要翻译： 短弧高压放电灯具有由石英玻璃制成的电弧管1，该发光管1包括在其内部充满水银的发光部分2，并且具有彼此相对配置的一对电极;密封部3， 发光部。 该对电极具有电极棒5a，电极棒的一端位于发光部的内部空间中，电极棒的另一端嵌入密封部，并与导电性金属 - 密封在密封部分的箔片7。 在嵌入密封部的电极棒的一部分的至少一部分中，其整个外周面被金属箔套7a紧密地覆盖。 获得了高效率和高品质的灯，其中在灯的寿命期间，由管中的超高蒸汽压力引起的电弧管的密封部分的断裂可靠地被抑制，并且电弧管中的蒸气压升高 至30MPa以上。

公开(公告)号：US20100097069A1

公开(公告)日：2010-04-22

申请号：US12443174

申请日：2007-10-02

申请人： Jun Sakaguchi ,  Hiroki Ogawa ,  Yoshiki Kitahara ,  Katsuhiro Ono ,  Kiyoshi Takahashi ,  Minoru Ozasa

发明人： Jun Sakaguchi ,  Hiroki Ogawa ,  Yoshiki Kitahara ,  Katsuhiro Ono ,  Kiyoshi Takahashi ,  Minoru Ozasa

IPC分类号： G01R31/00

CPC分类号： G03B21/2026 ,  G03B21/2053 ,  H01J61/86 ,  H05B41/2928

摘要： An image display device accurately evaluates the possibility of problems occurring due to the state of impure gas inside a discharge envelope in a high pressure discharge lamp. The image display device includes the high voltage discharge lamp and an evaluation unit (51) for evaluating the possibility of problems occurring due to the state of impure gas. The evaluation unit (51) includes a high voltage pulse generator (57) that generates a high voltage pulse for breaking insulation in the high pressure lamp, a constant current generator (58) that generates a constant current for illuminating the high pressure discharge lamp in a glow discharge state, a lamp voltage measurer (59) that measures lamp voltage during illumination in the glow discharge state, an LED (63), and a controller (65). When the lamp voltage measured by the lamp voltage measurer (59) is a predetermined value or higher, the controller (65) judges that the possibility of problems occurring in the high pressure lamp is high, and lights the LED (63).

摘要翻译： 图像显示装置准确地评估由于在高压放电灯中的放电外壳内的不纯气体的状态而发生问题的可能性。 图像显示装置包括高压放电灯和用于评估由于不纯气体的状态而发生问题的可能性的评估单元（51）。 评估单元（51）包括产生用于断开高压灯绝缘的高电压脉冲的高压脉冲发生器（57），产生用于照亮高压放电灯的恒定电流的恒流发生器（58） 辉光放电状态的灯电压测量器（59），用于在辉光放电状态下照明期间的灯电压的灯电压测量器（59），LED（63）和控制器（65）。 当由灯电压测量器（59）测量的灯电压是预定值或更高时，控制器（65）判断在高压灯中出现问题的可能性高，并点亮LED（63）。