公开(公告)号：US20050025710A1

公开(公告)日：2005-02-03

申请号：US10630375

申请日：2003-07-29

申请人： Michel Schneider ,  Yan Feng ,  Jean Brochot ,  David Lazurus

发明人： Michel Schneider ,  Yan Feng ,  Jean Brochot ,  David Lazurus

IPC分类号： A61K49/18 ,  A61K49/22 ,  A61K49/00

CPC分类号： A61K49/1815 ,  A61K49/225

摘要： The invention relates to a formulation comprising a dry material (e.g. lyophilised or spray dried) comprising at least one film forming surfactant and a gas or a gas mixture usable in diagnostic imaging, to a process for the preparation thereof and to a suspension obtainable by reconstituting said formulation with an aqueous carrier for use in contrast imaging. The invention also relates to a container comprising the dry material in contact with a gas. The gas associated with the dry material is at a pressure lower than the atmospheric pressure.

摘要翻译： 本发明涉及包含干物质（例如冻干或喷雾干燥的）的制剂，其包含至少一种成膜表面活性剂和可用于诊断成像的气体或气体混合物，其制备方法和可通过重构获得的悬浮液 所述制剂具有用于对比成像的水性载体。 本发明还涉及包含与气体接触的干燥材料的容器。 与干燥材料相关联的气体处于低于大气压的压力。

公开(公告)号：US08697875B2

公开(公告)日：2014-04-15

申请号：US13167540

申请日：2011-06-23

申请人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

发明人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

IPC分类号： A61P25/00 ,  A61P25/28 ,  C07D215/44

CPC分类号： A61K31/4706 ,  C07D215/48 ,  C07D215/54

摘要： The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.

摘要翻译： 本发明提供了磷酸二酯酶抑制剂的化合物。 本发明进一步提供了一种筛选结合并调节磷酸二酯酶蛋白质的化合物的方法。 本发明还提供了通过向受试者施用磷酸二酯酶结合化合物来治疗与累积的淀粉样蛋白-β肽沉积物积累相关的病症的方法。

公开(公告)号：US20080192347A1

公开(公告)日：2008-08-14

申请号：US11674532

申请日：2007-02-13

申请人： Wenbing Yun ,  Alan Francis Lyon ,  Yan Feng

发明人： Wenbing Yun ,  Alan Francis Lyon ,  Yan Feng

IPC分类号： G02B5/18 ,  G21K1/06

CPC分类号： G02B5/1876 ,  G02B5/1857 ,  G21K1/06

摘要： A method to stabilize planar nanostructures, for example grating and zone plate lenses that are typically used for directing or focusing x-ray radiation, includes the deposition of a top, stabilizing layer. The structures are typically made on a flat substrate, and therefore are only fixed at the bottom. At high aspect ratio, the stability can be poor since small forces such as electrostatic forces and van de Waals forces that are often present can alter the structure. The top coating of a metallic material such as titanium constrains the nanostructures at the top and at the same time eliminates electrostatic forces and reduces any thermal gradient that may be present across the device

摘要翻译： 稳定平面纳米结构的方法，例如通常用于引导或聚焦X射线辐射的光栅和区域透镜，包括顶部稳定层的沉积。 这些结构通常制成在平坦的基底上，因此仅固定在底部。 在高纵横比下，稳定性可能很差，因为通常存在的诸如静电力和​​范德瓦尔力的小力可能改变结构。 金属材料如钛的顶部涂层限制了顶部的纳米结构，同时消除静电力并减少可能存在于该装置上的任何热梯度

公开(公告)号：US20060050946A1

公开(公告)日：2006-03-09

申请号：US10435827

申请日：2003-05-12

申请人： Timothy Mitchison ,  Steven Altschuler ,  Yan Feng ,  Thomas Mayer ,  Zachary Perlman ,  Michael Slack ,  Lani Wu

发明人： Timothy Mitchison ,  Steven Altschuler ,  Yan Feng ,  Thomas Mayer ,  Zachary Perlman ,  Michael Slack ,  Lani Wu

IPC分类号： G06K9/00

CPC分类号： G06K9/0014 ,  G06T7/0012 ,  G06T2207/30024

摘要： The present invention provides methods and systems for automated morphological analysis of cells. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen. Agents which cause a particular phenotype in the cells can be identified using the inventive quantitative morphometric analysis of cells. The data gathered using the inventive method can also be quantified and analyzed later for various trends and classifications. Characteristics of cells which can be determined using this method include number of nuclei, size of cell, size of nuclei, number of the centrosomes, shape of cells, size of centrosomes, perimeter of nucleus, shape of nucleus, pattern of staining, and degree of staining.

摘要翻译： 本发明提供了用于细胞自动形态学分析的方法和系统。 本发明的方法在生物屏幕中所需的细胞的快速分析中特别有用。 可以使用本发明的细胞定量形态学分析来鉴定在细胞中引起特定表型的药剂。 使用本发明方法收集的数据也可以针对各种趋势和分类进行量化和分析。 可以使用该方法确定的细胞的特征包括细胞核的数量，细胞的大小，细胞核的大小，中心体的数量，细胞的形状，中心体的大小，细胞核的周长，细胞核的形状，染色的图案和程度 的染色。

公开(公告)号：USD434563S

公开(公告)日：2000-12-05

申请号：US119808

申请日：2000-03-07

申请人： Gary Lim ,  Yan Feng

设计人： Gary Lim ,  Yan Feng

公开(公告)号：USD1016590S1

公开(公告)日：2024-03-05

申请号：US29851399

申请日：2022-08-29

申请人： Yan Feng

设计人： Yan Feng

摘要： FIG. 1 is a front perspective view of a micro air chipping tool scraper showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a top view thereof; and,
FIG. 7 is a bottom view thereof.
Broken lines in the drawings depict portions of the micro air chipping tool scraper that form no part of the claimed design.

公开(公告)号：US11054627B2

公开(公告)日：2021-07-06

申请号：US16465451

申请日：2017-08-24

申请人： Yan Feng

发明人： Yan Feng

IPC分类号： G02B5/18 ,  G02B21/36 ,  G02B21/16 ,  G02B27/42 ,  G03H1/02

摘要： Disclosed is a four-dimensional (4D: 3D+time) multi-plane broadband imaging apparatus capable of recording 3D multi-plane and multi-colour images simultaneously. The apparatus includes: one or more non-reentry quadratically distorted (NRQD) gratings which can produce a focal length and a spatial position corresponding to each diffraction order, thus simultaneously transmitting wavefront information between multiple object/image planes and a single image/object plane; a grism system which can limit chromatically-induced lateral smearing by creating a collimated beam in which the spectral components are laterally displaced; a lens system which is configured to adjust the optical path; and the optical detector(s). In an optical system, the multiple object/image planes, the lens system, the grism system, the NRQD grating(s), the optical detector(s) and the single image/object plane are located on the same optical axis. This simple, easy-to-use and compact apparatus can meet many different requirements and serve a large range of high throughput applications.

公开(公告)号：US09969677B2

公开(公告)日：2018-05-15

申请号：US13996483

申请日：2011-12-22

申请人： Yitshak Francis ,  Mauro Fa ,  Ottavio Arancio ,  Jole Fiorito ,  Shixian Deng ,  Donald W. Landry ,  Michal Luzac ,  Yan Feng

发明人： Yitshak Francis ,  Mauro Fa ,  Ottavio Arancio ,  Jole Fiorito ,  Shixian Deng ,  Donald W. Landry ,  Michal Luzac ,  Yan Feng

IPC分类号： C07C217/22 ,  C07D209/48 ,  C07D295/088 ,  C07D265/14

CPC分类号： C07C217/22 ,  C07C217/58 ,  C07C235/60 ,  C07C235/64 ,  C07C251/24 ,  C07D209/48 ,  C07D265/14 ,  C07D265/36 ,  C07D295/088

摘要： The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

公开(公告)号：US20110038035A1

公开(公告)日：2011-02-17

申请号：US12812370

申请日：2009-01-16

申请人： Luke R. Taylor ,  Yan Feng ,  Wolfgang Hackenberg ,  Ronald Holzlöhner ,  Domenico Bonaccini Calia

发明人： Luke R. Taylor ,  Yan Feng ,  Wolfgang Hackenberg ,  Ronald Holzlöhner ,  Domenico Bonaccini Calia

IPC分类号： H01S3/30

CPC分类号： H01S3/302

摘要： Optical Raman fiber amplifier (20), with an amplification fiber, wherein at least one section thereof has a ratio of Raman gain coefficient gR to Brillouin gB gain coefficient of gR/gB larger than 0.001 at the fiber operating temperature and a vacuum wavelength of 1064 nm. The invention further refers to a corresponding light source, the use of a fiber and a method of amplifying light.

摘要翻译： 具有放大光纤的光拉曼光纤放大器（20），其中至少一个部分在光纤工作温度下的拉曼增益系数gR与布里渊gB增益系数gR / gB大于0.001，真空波长为1064 nm。 本发明还涉及相应的光源，光纤的使用和放大光的方法。

公开(公告)号：US07864426B2

公开(公告)日：2011-01-04

申请号：US11674532

申请日：2007-02-13

申请人： Wenbing Yun ,  Alan Francis Lyon ,  Yan Feng

发明人： Wenbing Yun ,  Alan Francis Lyon ,  Yan Feng

IPC分类号： G02B5/18

CPC分类号： G02B5/1876 ,  G02B5/1857 ,  G21K1/06

摘要： A method to stabilize planar nanostructures, for example grating and zone plate lenses that are typically used for directing or focusing x-ray radiation, includes the deposition of a top, stabilizing layer. The structures are typically made on a flat substrate, and therefore are only fixed at the bottom. At high aspect ratio, the stability can be poor since small forces such as electrostatic forces and van de Waals forces that are often present can alter the structure. The top coating of a metallic material such as titanium constrains the nanostructures at the top and at the same time eliminates electrostatic forces and reduces any thermal gradient that may be present across the device.

摘要翻译： 稳定平面纳米结构的方法，例如通常用于引导或聚焦X射线辐射的光栅和区域透镜，包括顶部稳定层的沉积。 这些结构通常制成在平坦的基底上，因此仅固定在底部。 在高纵横比下，稳定性可能很差，因为通常存在的诸如静电力和​​范德瓦尔力的小力可能改变结构。 诸如钛的金属材料的顶部涂层限制了顶部的纳米结构，同时消除了静电力并且减少了可能存在于该器件上的任何热梯度。