摘要:
The current invention is related to peptide-immunoglobulin-conjugates in which at least two of the termini of the immunoglobulin polypeptide chains are conjugated to a peptide, whereby the peptides can be different, similar or identical. The conjugation is effected on the nucleic acid level.
摘要:
The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
摘要:
The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of the anti-CCR5 antibody and to the pharmaceutical use of the conjugate.
摘要:
The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
摘要:
Disclosed is a device and a method for feeding primary combustion air for the combustion of coke oven gas into a coking chamber of a coke oven of the non-recovery or heat recovery type, the coke oven is provided with openings in the oven chamber through which the oven chamber can be charged with primary air, and heating flues in the oven chamber sole with openings through which the heating flues can be charged with secondary air, and downcomer-channels which allow for guiding partially burned gas for combustion with secondary air from the oven chamber into the heating flues, wherein in the oven wall above the door or in the upper door area there are one or more non-controlled openings comprised of a heat-proof material through which part of the primary air can be guided, and in the top area of the oven there are further controllable air feeder ducts conducting primary air through the oven top.
摘要:
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要:
An electrical power distribution device such as a junction box or the like includes a status indicator that also serves not only to indicate the status of energization of a connector mounted in a first housing opening, but also to illuminate a translucent indicia-bearing plate mounted in second housing opening. The housing contains a chamber in which are mounted a light emitting diode that is energized simultaneously with the connector, and a light transmitting member that directs the light produced by the LED toward the second housing opening.
摘要:
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要:
This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as well as processes for their manufacture. The compounds according to this invention possess anti-cell proliferation activity and show an increased plasma-stability.
摘要:
Coking system, wherein the coking blends particularly based on hard coal, are fed batchwise to a reactor (1), which is heated indirectly by heat recovery in regenerators (I, II) or recuperators, whereby the reactor is built as a high-capacity coking reactor (100), several high-capacity coking reactors are combined to form a reactor block and the high-capacity coking reactors are built as mutually independent modules, whereby each module can be operated or optionally replaced independently of the neighboring modules, with little or no impairment of the operation of the neighboring modules. The individual reactors are independently operatable in terms of statics and heat supply. The regenerators, or recuperators (I, II, R, R') can be arranged laterally or underneath the reactor chamber. Neighboring reactors can have a common intermediate wall (2). The reactor chambers have a width of at least 0.7 m, a height of at least 8.5 m and a length of at least 18 m.