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公开(公告)号：US20110165182A1
公开(公告)日：2011-07-07
申请号：US13050615
申请日：2011-03-17
申请人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
发明人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
IPC分类号： A61K39/395 , C07K19/00 , A61P31/18 , A61P31/12
CPC分类号： C07K16/2866 , C07K14/005 , C07K2319/00 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
摘要翻译： 本发明涉及包含一种或多种抗融合肽和抗CCR5抗体（mAb CCR5）的缀合物，其特征在于，一至八个抗融合肽各自与所述抗 - 抗体的重链和/或轻链的一个末端缀合， CCR5抗体和所述缀合物的药物用途。
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公开(公告)号：US07951920B2
公开(公告)日：2011-05-31
申请号：US11893899
申请日：2007-08-17
申请人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
发明人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
CPC分类号： C07K16/2866 , C07K14/005 , C07K2319/00 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of the anti-CCR5 antibody and to the pharmaceutical use of the conjugate.
摘要翻译： 本发明涉及包含一种或多种抗融合肽和抗CCR5抗体（mAb CCR5）的缀合物，其特征在于，一至八个抗融合肽各自与抗-CD5抗体的重链和/或轻链的一个末端缀合， CCR5抗体和缀合物的药物用途。
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公开(公告)号：US20090028881A1
公开(公告)日：2009-01-29
申请号：US11893899
申请日：2007-08-17
申请人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
发明人： Michael Brandt , Stephan Fischer , Erhard Kopetzki , Suryanarayana Sankuratri , Ralf Schumacher
IPC分类号： C07K16/46 , A61K39/395 , C12P21/08 , A61P31/12 , A61P31/18
CPC分类号： C07K16/2866 , C07K14/005 , C07K2319/00 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
摘要翻译： 本发明涉及包含一种或多种抗融合肽和抗CCR5抗体（mAb CCR5）的缀合物，其特征在于，一至八个抗融合肽各自与所述抗 - 抗体的重链和/或轻链的一个末端缀合， CCR5抗体和所述缀合物的药物用途。
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公开(公告)号：US20070148180A1
公开(公告)日：2007-06-28
申请号：US11583547
申请日：2006-10-19
CPC分类号： C07K14/70514 , C07K2319/30
摘要： The current invention is related to peptide-immunoglobulin-conjugates in which at least two of the termini of the immunoglobulin polypeptide chains are conjugated to a peptide, whereby the peptides can be different, similar or identical. The conjugation is effected on the nucleic acid level.
摘要翻译： 本发明涉及肽 - 免疫球蛋白缀合物，其中免疫球蛋白多肽链的至少两个末端与肽缀合，由此肽可以是不同的，相似的或相同的。 缀合在核酸水平上进行。
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公开(公告)号：US20090022720A1
公开(公告)日：2009-01-22
申请号：US12218693
申请日：2008-07-17
IPC分类号： A61K39/395 , C07K16/00 , C12P21/00 , C07K14/00 , A61P31/18
CPC分类号： C07K14/005 , A61K47/6811 , A61K47/6849 , C07K16/2812 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C12N2740/16122
摘要： The current invention is related to a conjugate comprising two or more antifusogenic peptides and an anti-CD4 antibody (mAb CD4) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CD4 antibody and to the pharmaceutical use of said conjugate.
摘要翻译： 本发明涉及包含两种或多种抗融合肽和抗-CD4抗体（mAb CD4）的缀合物，其特征在于，一至八个抗融合肽各自与所述抗生素肽的重链和/或轻链的一个末端缀合， CD4抗体和所述缀合物的药物用途。
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公开(公告)号：US10280214B2
公开(公告)日：2019-05-07
申请号：US13464878
申请日：2012-05-04
摘要： Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule−linkern)m−conjugation partner−(linkero−repeat-motif-molecule)p, wherein n and o are independently of each other and independently for each value of m and p integer values of 0 or 1, and m and p are independently of each other integer values of 0 or 1 or 2 or 3 or 4 or 5 or 6 or 7, and wherein the repeat-motif-molecule conjugate comprises at least one oligosaccharide attached to a glycosylation site. Also reported are encoding nucleic acids and method for producing these repeat-motif-conjugates in mammalian cells.
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公开(公告)号：US07537755B2
公开(公告)日：2009-05-26
申请号：US11839493
申请日：2007-08-15
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20080171363A1
公开(公告)日：2008-07-17
申请号：US11838730
申请日：2007-08-14
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20080076710A1
公开(公告)日：2008-03-27
申请号：US11744424
申请日：2007-05-04
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20070225204A1
公开(公告)日：2007-09-27
申请号：US11532024
申请日：2006-09-14
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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