公开(公告)号：US20220056136A1

公开(公告)日：2022-02-24

申请号：US17298741

申请日：2019-02-15

Applicant: ABL BIO INC. ,  I-MAB BIOPHARMA CO., LTD

Inventor： Eunyoung PARK ,  Yangsoon LEE ,  Hyejin CHUNG ,  Eunsil SUNG ,  Jiseon YOO ,  Minji PARK ,  Yong-Gyu SON ,  Hyoju CHOI ,  Eunjung KIM ,  Jaeho JUNG ,  Weon-Kyoo YOU ,  Sang Hoon LEE ,  Lei FANG ,  Wenqing JIANG

IPC: C07K16/28 ,  C07K16/46

Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.

公开(公告)号：US20210284749A1

公开(公告)日：2021-09-16

申请号：US17053256

申请日：2019-06-26

Applicant: ABL BIO INC.

Inventor： Kyungjin PARK ,  Hyejin CHUNG ,  Kyeongsu PARK ,  Yangsoon LEE ,  Mikyung CHANG ,  Jaehyoung JEON ,  Youngkwang KIM ,  Junhyun JEONG ,  Jiseon YOO ,  Yeunju KIM ,  Donghoon YEOM ,  Eunjung KIM ,  Bora LEE ,  Jinwon JUNG

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.

公开(公告)号：US20250066487A1

公开(公告)日：2025-02-27

申请号：US18935875

申请日：2024-11-04

Applicant: ABL Bio Inc. ,  YUHAN CORPORATION

Inventor： Yeryoung YONG ,  Ui-Jung JUNG ,  Hyejin CHUNG ,  Kyeongsu PARK ,  Wonjun SON ,  Yangsoon LEE ,  Yeunju KIM ,  Eunsil SUNG ,  Youngkwang KIM ,  Youngdon PAK ,  Minji PARK ,  Jaehyun EOM ,  Hyoju CHOI ,  Moo Young SONG ,  Na Rae LEE ,  Young Bong PARK ,  Eun-Jung LEE ,  Eun-Jung LEE

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395

Abstract: Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US12195538B2

公开(公告)日：2025-01-14

申请号：US17298741

申请日：2019-02-15

Applicant: ABL BIO INC. ,  I-MAB BIOPHARMA US LIMITED

Inventor： Eunyoung Park ,  Yangsoon Lee ,  Hyejin Chung ,  Eunsil Sung ,  Jiseon Yoo ,  Minji Park ,  Yong-Gyu Son ,  Hyoju Choi ,  Eunjung Kim ,  Jaeho Jung ,  Weon-Kyoo You ,  Sang Hoon Lee ,  Lei Fang ,  Wenqing Jiang

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46

Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.

公开(公告)号：US12195537B2

公开(公告)日：2025-01-14

申请号：US17296752

申请日：2019-12-02

Applicant: ABL Bio Inc.

Inventor： Eunyoung Park ,  Yangsoon Lee ,  Hyejin Chung ,  Uijung Jung ,  Youngdon Pak ,  Jun Hyun Jeong ,  Yeunju Kim ,  Seawon Ahn ,  Byungje Sung

IPC: G01N31/00 ,  A61P35/00 ,  C07K16/28 ,  C07K16/46 ,  G01N33/53

Abstract: Provided is an anti-4-1BB antibody or an antigen-binding fragment thereof, and uses thereof.

公开(公告)号：US12168690B2

公开(公告)日：2024-12-17

申请号：US16939472

申请日：2020-07-27

Applicant: ABL Bio Inc. ,  YUHAN CORPORATION

Inventor： Yeryoung Yong ,  Ui-Jung Jung ,  Hyejin Chung ,  Kyeongsu Park ,  Wonjun Son ,  Yangsoon Lee ,  Yeunju Kim ,  Eunsil Sung ,  Youngkwang Kim ,  Youngdon Pak ,  Minji Park ,  Jaehyun Eom ,  Hyoju Choi ,  Moo Young Song ,  Na Rae Lee ,  Young Bong Park ,  Eun-Jung Lee ,  Eun-Jung Lee

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395

Abstract: Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US20230357412A1

公开(公告)日：2023-11-09

申请号：US18063550

申请日：2022-12-08

Applicant: ABL BIO INC.

Inventor： Sungwon AN ,  Jinhyung AHN ,  Byungje SUNG ,  Dongin KIM ,  Daehae SONG ,  Jaehyun EOM ,  Yong-Gyu SON ,  Juhee KIM ,  Kyungjin PARK ,  Jinwon JUNG ,  Bora LEE ,  Hyesu YUN

IPC: A61P25/28 ,  C07K16/18 ,  C07K16/28

CPC classification number: C07K16/2863 ,  A61P25/28 ,  C07K16/18 ,  A61K2039/505

Abstract: The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20230192861A1

公开(公告)日：2023-06-22

申请号：US17778382

申请日：2020-11-23

Applicant: ABL BIO INC. ,  I-MAB

Inventor： Eunsil Sung ,  Eunyoung Park ,  Jaehyoung Jeon ,  Junhyun Jeong ,  Daehae Song ,  Sunju Lee ,  Lei Fang ,  Wenqing Jiang ,  Feifei Cui

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2827 ,  C07K16/2878 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/24 ,  C07K2317/21 ,  C07K2317/92 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/55 ,  C07K2317/732 ,  A61K2039/505

Abstract: The present disclosure provides an anti-PD-L1/anti-B7-H3 multispecific antibody capable to effectively block the interaction between PD-L1 and its receptor PD-1, and suppress the T-cell inhibitory effect of B7-H3 protein. The multispecific antibody may have high binding affinity to both of a PD-L1 protein and a B7-H3 protein.

公开(公告)号：US20220348675A1

公开(公告)日：2022-11-03

申请号：US17683869

申请日：2022-03-01

Applicant: I-Mab Biopharma US Limited ,  ABL Bio Inc.

Inventor： Wenqing Jiang ,  Lei Fang ,  Zhengyi Wang ,  Bingshi Guo ,  Eunyoung Park ,  Eunsil Sung ,  Byungje Sung

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided are bispecific and multi-specific antibodies that target both claudin 18.2 (CLDN18.2) and 4-1BB. These antibodies, in the absence of CLDN18.2-expressing cells, can bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of CLDN18.2-expressing cells, however, these antibodies can trigger CLDN18.2-dependent 4-1BB signaling, leading to potent immune response to the CLDN18.2-expressing tumor cells.

公开(公告)号：US20220125944A1

公开(公告)日：2022-04-28

申请号：US17436647

申请日：2020-03-06

Applicant: ABL BIO, INC.

Inventor： Jinwon JUNG ,  Juhee KIM ,  Youngdon Pak ,  Daehae SONG ,  Donghoon YEOM ,  Jaehyun EOM ,  Youngeun HONG ,  Bora LEE

IPC: A61K47/68 ,  C07H15/26 ,  A61K47/54

Abstract: The present invention relates to a novel compound comprising a galactose trigger moiety and cyclopropabenzindole (CBI), and an antibody-drug conjugate prepared by using same.