公开(公告)号：US12221574B2

公开(公告)日：2025-02-11

申请号：US16970273

申请日：2019-02-15

Applicant: OSAKA UNIVERSITY ,  National University Corporation Tokai National Higher Education and Research System ,  NICHIA CORPORATION

Inventor： Susumu Kuwabata ,  Taro Uematsu ,  Kazutaka Wajima ,  Tsukasa Torimoto ,  Tatsuya Kameyama ,  Daisuke Oyamatsu

IPC: C09K11/62 ,  B82Y20/00 ,  B82Y40/00 ,  H01L33/50

Abstract: Provided are core-shell semiconductor nanoparticles, each including a core and a shell disposed on a surface of the core, and emitting light when irradiated with light. The core contains a semiconductor containing M1, M2, and Z, M1 containing at least one selected from the group consisting of Ag, Cu, and Au, M2 containing at least one selected from the group consisting of Al, Ga, In, and Tl, and Z containing at least one selected from the group consisting of S, Se, and Te. The shell contains a semiconductor containing a Group 13 element and a Group 16 element, and having a greater band-gap energy than the core. The shell has a compound containing a Group 15 element disposed on a surface of the shell, and the Group 15 element containing at least P with a negative oxidation number.

公开(公告)号：US20250042982A1

公开(公告)日：2025-02-06

申请号：US18717136

申请日：2022-12-06

Applicant: OSAKA UNIVERSITY ,  PERIOTHERAPIA CO., LTD.

Inventor： Yoshiaki TANIYAMA ,  Fumihiro SANADA ,  Ryuichi MORISHITA

IPC: C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An object is to provide a novel antibody or antigen-binding fragment thereof against exon 21 of human periostin. The object is achieved by an antibody or antigen-binding fragment thereof bindable to a conformational epitope on human periostin, wherein the epitope contains the amino acid sequence A represented by SEQ ID NO: 61 and the amino acid sequence B represented by any one of SEQ ID NOs: 62 to 64.

公开(公告)号：US20250018014A1

公开(公告)日：2025-01-16

申请号：US18753584

申请日：2024-06-25

Applicant: OSAKA UNIVERSITY ,  CHUGAI SEIYAKU KABUSHIKI KAISHA

Inventor： Shizuo AKIRA ,  Takashi SATOH ,  Hiroki TANAKA ,  Keiko SAITO ,  Yusuke YAMAGISHI

IPC: A61K38/45 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P25/00 ,  A61P27/02 ,  A61P37/06 ,  C07K7/64 ,  C07K16/40 ,  C12Q1/48 ,  G01N33/573

Abstract: The present invention found that, for example, inhibiting phosphorylation of a Ser residue in Regnase-1 is effective in treating and/or preventing diseases. The invention also found that, for example, inhibiting the binding of Regnase-1 with at least one factor selected from the group consisting of TBK1, IKKi, Act-1, IKK, and IRAK is effective in treating and/or preventing diseases.

公开(公告)号：US20250014856A1

公开(公告)日：2025-01-09

申请号：US18694239

申请日：2022-10-05

Applicant: OSAKA UNIVERSITY

Inventor： Haruyasu ASAHARA ,  Maiko MORIGUCHI ,  Tsuyoshi INOUE

IPC: H01J37/20 ,  C01B32/194 ,  G01N1/36

Abstract: A graphene grid that can reduce or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance, and can capture the structural analysis target substance with high efficiency and analyze the structural analysis target substance with high resolution, in structural analysis by cryo-electron microscopy. To achieve the above object, the graphene grid has a graphene surface onto which a functional group containing at least one of a silicon atom or a phosphorus atom is introduced.

公开(公告)号：US12187691B2

公开(公告)日：2025-01-07

申请号：US17433126

申请日：2020-02-20

Applicant: OSAKA UNIVERSITY ,  N.E. CHEMCAT CORPORATION

Inventor： Kiyotomi Kaneda ,  Takato Mitsudome ,  Miho Kimura ,  Yukio Takagi ,  Yosuke Imanaka ,  Hiroyasu Suzuka ,  Tatsuya Kojima

IPC: C07D295/023 ,  B01J27/18 ,  B01J27/19 ,  B01J37/02 ,  B01J37/04 ,  C07D487/04

Abstract: Provided is a catalyst for amide compound hydrogenation characterized in that rhodium and molybdenum are supported on hydroxyapatite, the catalyst for amide compound hydrogenation providing a catalyst that can promote a reduction reaction that converts an amide compound into an amine compound, can be used under moderate conditions, and has durability that allows repeated use thereof while retaining high activity. Also provided is a method for producing an amine compound, the method being characterized by including bringing an amide compound into contact with the catalyst for amide compound hydrogenation to cause hydrogenation, thereby producing an amine compound.

公开(公告)号：US12186456B2

公开(公告)日：2025-01-07

申请号：US17266382

申请日：2019-08-05

Applicant: OSAKA UNIVERSITY ,  Aimedic MMT CO., LTD.

Inventor： Satoshi Hamaguchi ,  Tomoko Deguchi ,  Satoshi Sugimoto ,  Takashi Kaito ,  Hideki Yoshikawa ,  Chieko Asamori

IPC: A61L27/56 ,  A61L27/10 ,  A61L27/34

Abstract: To provide an artificial bone having a porous structure with an improved affinity to osteogenic cells, an artificial bone (1) includes: a base material (2) containing porous ceramics provided with mutually interconnected multiple pores (6); a carbonaceous thin film (10) formed on an outer surface of the base material and wall surfaces (7) of the pores; and functional groups (13) including amino groups (12) provided on a surface and in an interior of the carbonaceous thin film.

公开(公告)号：US12174118B2

公开(公告)日：2024-12-24

申请号：US17228220

申请日：2021-04-12

Applicant: SYSMEX CORPORATION ,  OSAKA UNIVERSITY

Inventor： Takahiro Tougan ,  Yuji Toya

IPC: G01N21/64 ,  G01N1/31 ,  G01N21/49 ,  G16H10/40 ,  G16H40/63 ,  G16H50/30

Abstract: Disclosed is a blood analyzer including: a first sample preparation unit configured to prepare, from a blood sample, a first measurement sample for measuring a red blood cell infected with malaria; a second sample preparation unit configured to prepare, from the blood sample, a second measurement sample for measuring intrinsic fluorescence of a red blood cell; a light source unit configured to apply light to the first and the second measurement samples; a detection unit configured to detect fluorescence and scattered light generated from the first measurement sample to which light has been applied, and detect intrinsic fluorescence generated from the second measurement sample to which light has been applied; and an information processing unit configured to generate information about malaria infection based on fluorescence and scattered light detected from the first measurement sample, and generate information about iron-deficiency anemia based on intrinsic fluorescence detected from the second measurement sample.

公开(公告)号：US12171528B2

公开(公告)日：2024-12-24

申请号：US17628394

申请日：2020-02-19

Applicant: OSAKA UNIVERSITY

Inventor： Yoshie Sugiyama

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/055 ,  G06T7/00

Abstract: A blood vessel wall thickness estimation method includes: obtaining behavioral information, which is numerical information about changes over time in positions of a plurality of predetermined points in a blood vessel wall, based on a video including the blood vessel wall obtained using four-dimensional angiography; generating estimation information for estimating a thickness of the blood vessel wall based on the behavioral information obtained in the obtaining; and outputting the estimation information generated in the generating. The estimation information is information in which at least one of the following is visualized: a change in displacement over time; a change in speed over time; a change in acceleration over time; a change in kinetic energy over time; a spring constant obtained from the displacement and the acceleration, and a Fourier coefficient obtained from the change in the displacement over time.

公开(公告)号：US20240410891A1

公开(公告)日：2024-12-12

申请号：US18579988

申请日：2021-07-19

Applicant: Shimadzu Corporation ,  OSAKA UNIVERSITY

Inventor： Mami OKAMOTO ,  Yohei YAMADA ,  Nobuyuki OKAHASHI ,  Fumio MATSUDA

IPC: G01N33/58

Abstract: In a method for creating isotope distribution data, samples for analysis having different concentrations of metabolites are prepared as samples containing metabolites of cells cultured in a medium containing a substrate labeled with a stable isotope, mass spectrometry is performed on each under the same analysis condition, mass spectrum data is analyzed for each to identify the type of the metabolites, and there are determined the number of metabolites included in a metabolite group made of unlabeled metabolites and/or isotopic isomers, and the signal intensities of mass peaks corresponding to all isotope isomers included in the metabolite group. The number of metabolites corresponding to all types of metabolites and the signal intensity are compared among the samples to select a sample for analysis for obtaining the isotope distribution, and data on the isotope distribution of the metabolite is integrated to create the isotope distribution data of the metabolite.

公开(公告)号：US12162088B2

公开(公告)日：2024-12-10

申请号：US16803121

申请日：2020-02-27

Applicant: Mitsubishi Electric Corporation ,  OSAKA UNIVERSITY

Inventor： Tetsuya Amasaki ,  Hidetoshi Fujii ,  Keisuke Murase ,  Seiiyu Ishimoto ,  Takuya Ikeda ,  Muneaki Mukuda ,  Takushi Takizawa ,  Naohiko Harada ,  Shigenobu Tochiyama

IPC: B23K20/12 ,  B23K103/10

Abstract: A pressure receiving surface inclined to a rotation axis is provided on the side surface of a stir probe of a rotating tool. The pressure receiving surface includes a pressure receiving region which is always perpendicular to a rotation tangential direction in a cross section perpendicular to the rotation axis. In friction stir processing, the stir probe is caused to rotate in a rotation direction B in which the normal direction of the pressure receiving surface is positive. According to this kind of rotating tool, as it has no shoulder, a joint width does not increase even when a stirring region is deep, and also, a plastic flow in a rotation direction is generated by a pressure receiving surface, so that it is possible to reduce the proportion of the plastic flow in the rotation axis direction, and thus possible to suppress an occurrence of burr.