公开(公告)号：US20220220192A1

公开(公告)日：2022-07-14

申请号：US17585174

申请日：2022-01-26

申请人： UCB BIOPHARMA SRL

发明人： Ralph ADAMS ,  Patrick DOWNEY ,  Terence Seward BAKER ,  Kerry Louise TYSON ,  Lorenzo DE LICHTERVELDE ,  Daniel John LIGHTWOOD ,  David James MCMILLAN

IPC分类号： C07K16/18

摘要： The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

公开(公告)号：US11345760B2

公开(公告)日：2022-05-31

申请号：US15321055

申请日：2015-06-25

申请人： UCB BIOPHARMA SRL

发明人： Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

IPC分类号： C07K16/46

摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

公开(公告)号：US20220144941A1

公开(公告)日：2022-05-12

申请号：US17286247

申请日：2019-10-16

申请人： UCB BIOPHARMA SRL

发明人： Melissa Kaye Brock ,  William James Byrnes ,  Bernhard Heinrich Greve ,  Claus Peter Kiessling ,  Grant Langdon ,  Elizabeth Webster Manis

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P21/04

摘要： The disclosure relates to a method of treating or preventing Myasthenia Gravis (MG) in a human in need thereof using an anti-FcRn antibody or antigen binding fragment thereof. In particular, the method provides suitable dosage regimens for such treatment.

公开(公告)号：US11292831B2

公开(公告)日：2022-04-05

申请号：US16772043

申请日：2018-12-13

申请人： UCB Biopharma SRL

发明人： Patrick Downey ,  Kerry Louise Tyson ,  Marco Kriek ,  Lorenzo De Lichtervelde ,  Daniel John Lightwood ,  David James McMillan ,  Peter Charles Elliott ,  Terence Seward Baker

IPC分类号： C07K16/18 ,  A61P25/16 ,  A61K39/00

摘要： The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

公开(公告)号：US11261242B2

公开(公告)日：2022-03-01

申请号：US16771993

申请日：2018-12-13

申请人： UCB Biopharma SRL

发明人： Ralph Adams ,  Patrick Downey ,  Terence Seward Baker ,  Kerry Louise Tyson ,  Lorenzo De Lichtervelde ,  Daniel John Lightwood ,  David James McMillan

IPC分类号： C07K16/18 ,  A61K39/00

摘要： The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

公开(公告)号：US20220025033A1

公开(公告)日：2022-01-27

申请号：US17500616

申请日：2021-10-13

申请人： UCB BIOPHARMA SRL ,  SANOFI

发明人： Alastair David Griffiths LAWSON ,  Daniel John LIGHTWOOD ,  Rebecca Jayne MUNRO ,  James Philip O'CONNELL ,  John Robert PORTER

IPC分类号： C07K16/24

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US11174311B2

公开(公告)日：2021-11-16

申请号：US16470999

申请日：2017-12-13

申请人： UCB BIOPHARMA SRL ,  SANOFI

发明人： Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro ,  James Philip O'Connell ,  John Robert Porter

IPC分类号： C07K16/24

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US11142794B2

公开(公告)日：2021-10-12

申请号：US15763890

申请日：2016-10-04

申请人： UCB BIOPHARMA SRL ,  BIOGEN MA INC.

发明人： Geoffrey Johnston ,  Carrie G. Wager ,  Huo Li ,  Ann Ranger

IPC分类号： C12Q1/68 ,  C12Q1/6883

摘要： The present invention relates to molecular signatures that can be used to identify patients diagnosed with an autoimmune disease, in particular with systemic lupus erythematosus for treatment with a CD40 or CD40L antagonist such as anti-CD40 antibody, anti-CD40L antibody or a binding fragment thereof. The signatures can also be used to monitor target engagement and response to treatment.

公开(公告)号：US20210252012A1

公开(公告)日：2021-08-19

申请号：US17176018

申请日：2021-02-15

申请人： UCB Biopharma SRL ,  SANOFI

发明人： Daniel Christopher Brookings ,  Teresa De Haro Garcia ,  Yann Foricher ,  Helen Tracey Horsley ,  Martin Clive Hutchings ,  James Andrew Johnson ,  Malcolm Maccoss ,  Mengyang Xuan ,  Zhaoning Zhu

IPC分类号： A61K31/55 ,  C07D487/18

摘要： A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

公开(公告)号：US20210163586A1

公开(公告)日：2021-06-03

申请号：US17172109

申请日：2021-02-10

申请人： UCB BIOPHARMA SRL

发明人： NEESHA DEDI ,  BREDA TWOMEY ,  MICHAEL JOHN WRIGHT ,  GARETH DAVIES ,  DAVID JAMES MCMILLAN

IPC分类号： C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68

摘要： This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.