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21.发明授权Compositions and methods for identifying enzyme and transport protein inhibitors 有权用于鉴定酶和转运蛋白抑制剂的组合物和方法公开(公告)号：US09518254B2
公开(公告)日：2016-12-13
申请号：US13266777
申请日：2010-05-03
申请人： Roland Wolkowicz
发明人： Roland Wolkowicz
CPC分类号： C12Q1/37 , C07K2319/01 , C07K2319/02 , C07K2319/03 , C12N9/506 , C12N2503/02 , C12N2510/00 , C12Y304/23016 , G01N33/5076 , G01N2333/9513 , G01N2500/02 , G01N2500/10
摘要： The invention is directed to compositions to screen for small molecule drugs that inhibit proteases, such as viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., HIV proteases. In alternative embodiments, the invention provides cell-based assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelop protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products.
摘要翻译： 本发明涉及筛选抑制蛋白酶的小分子药物的组合物，例如病毒蛋白酶，例如HIV蛋白酶; 以及制备和使用这些组合物的方法。 本发明提供用于鉴定可抑制蛋白酶例如HIV蛋白酶的组合物的组合物和方法，例如药物分子。 在替代实施方案中，本发明提供了基于细胞的测定法，以筛选抑制或改变酶活性的组合物，例如小分子或药物，所述酶例如涉及HIV包膜蛋白加工的钙依赖性蛋白质转化酶，包括HIV的切割 gp160信封前体，产生gp120和gp41信封产品。
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公开(公告)号：US20130052633A1
公开(公告)日：2013-02-28
申请号：US13542551
申请日：2012-07-05
申请人： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
发明人： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
CPC分类号： C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , C12Q1/707 , G01N2333/186 , G01N2333/9513 , G01N2500/00
摘要： Replicons of genotype 3 of hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 3 replicons and methods of using these replicons to screen antiviral agents are also provided.
摘要翻译： 提供丙型肝炎病毒（HCV）基因型3的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型3复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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23.发明申请COMPOSITIONS AND METHODS FOR IDENTIFYING ENZYME AND TRANSPORT PROTEIN INHIBITORS 有权用于鉴定酶和运输蛋白抑制剂的组合物和方法公开(公告)号：US20120172253A1
公开(公告)日：2012-07-05
申请号：US13266777
申请日：2010-05-03
申请人： Roland Wolkowicz
发明人： Roland Wolkowicz
CPC分类号： C12Q1/37 , C07K2319/01 , C07K2319/02 , C07K2319/03 , C12N9/506 , C12N2503/02 , C12N2510/00 , C12Y304/23016 , G01N33/5076 , G01N2333/9513 , G01N2500/02 , G01N2500/10
摘要： The invention is directed to compositions to screen for small molecule drugs that inhibit proteases, such as viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., HIV proteases. In alternative embodiments, the invention provides cell-based assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelop protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products.
摘要翻译： 本发明涉及筛选抑制蛋白酶的小分子药物的组合物，例如病毒蛋白酶，例如HIV蛋白酶; 以及制备和使用这些组合物的方法。 本发明提供用于鉴定可抑制蛋白酶例如HIV蛋白酶的组合物的组合物和方法，例如药物分子。 在替代实施方案中，本发明提供了基于细胞的测定法，以筛选抑制或改变酶活性的组合物，例如小分子或药物，所述酶例如涉及HIV包膜蛋白加工的钙依赖性蛋白质转化酶，包括HIV的切割 gp160信封前体，产生gp120和gp41信封产品。
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