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公开(公告)号：US08889849B2
公开(公告)日：2014-11-18
申请号：US13542554
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
IPC: C12Q1/70 , C12Q1/66 , C12N15/86 , C12N5/10 , C12N5/071 , C07K14/005 , G01N33/576 , C12Q1/68 , C12N15/64 , C12N15/65
CPC classification number: C12N15/86 , C07K14/005 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , G01N33/5767 , G01N2333/186
Abstract: Replicons of genotype 4 hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 4 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供基因型4丙型肝炎病毒（HCV）的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型4复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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公开(公告)号：US08889848B2
公开(公告)日：2014-11-18
申请号：US13542551
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
IPC: C12Q1/70 , C12Q1/66 , C12N15/86 , C12N5/10 , C12N5/071 , C07K14/005 , C12Q1/68 , C12N15/64 , C12N15/65
CPC classification number: C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , C12Q1/707 , G01N2333/186 , G01N2333/9513 , G01N2500/00
Abstract: Replicons of genotype 3 of hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 3 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供丙型肝炎病毒（HCV）基因型3的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型3复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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公开(公告)号：US20130052634A1
公开(公告)日：2013-02-28
申请号：US13542554
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Betty Peng
CPC classification number: C12N15/86 , C07K14/005 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , G01N33/5767 , G01N2333/186
Abstract: Replicons of genotype 4 hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 4 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供基因型4丙型肝炎病毒（HCV）的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型4复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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公开(公告)号：US20130052633A1
公开(公告)日：2013-02-28
申请号：US13542551
申请日：2012-07-05
Applicant: William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
Inventor： William E. Delaney, IV , Guofeng Cheng , Hongmei Mo , Simin Xu , Mei Yu , Amoreena Corsa
CPC classification number: C07K14/005 , C12N15/86 , C12N2770/24222 , C12N2770/24231 , C12N2770/24243 , C12Q1/707 , G01N2333/186 , G01N2333/9513 , G01N2500/00
Abstract: Replicons of genotype 3 of hepatitis C virus (HCV) are provided. These replicons contains adaptive mutations giving rise to the HCV's capability to replicate in vitro. Methods of preparing genotype 3 replicons and methods of using these replicons to screen antiviral agents are also provided.
Abstract translation: 提供丙型肝炎病毒（HCV）基因型3的复制品。 这些复制子包含适应性突变，导致HCV在体外复制的能力。 还提供了制备基因型3复制子的方法和使用这些复制子筛选抗病毒剂的方法。
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