公开(公告)号：US11666606B2

公开(公告)日：2023-06-06

申请号：US16746541

申请日：2020-01-17

申请人： Prime Merger Sub, LLC

发明人： Jeffrey S. White ,  Robin R. Young

IPC分类号： A61K35/50 ,  A61K38/57 ,  A61L27/54 ,  A61L27/36 ,  A61K9/00 ,  A61K47/36

CPC分类号： A61K35/50 ,  A61K38/57 ,  A61L27/3604 ,  A61L27/54 ,  A61K9/0019 ,  A61K47/36 ,  A61L2300/434 ,  A61L2430/24

摘要： Methods for treating joint diseases, disorders, and conditions, such as osteoarthritis, with a composition containing a therapeutically effective amount of tissue inhibitors of matrix metalloproteinases (TIMPs) are provided. The composition can contain TIMPs as part of amniotic fluid, or the TIMPs can be isolated from another source or recombinantly produced. The methods are particularly useful for treating osteoarthritis associated with degradation of articular cartilage by proteases. Also provided are methods of lubricating a joint, such as an osteoarthritic joint.

公开(公告)号：US20230159624A1

公开(公告)日：2023-05-25

申请号：US16960010

申请日：2018-12-20

申请人： XI'AN JIAOTONG-LIVERPOOL UNIVERSITY

发明人： Meng Huee LEE ,  Bingjie JIANG ,  Jian LIU

IPC分类号： C07K14/81 ,  A61K38/57 ,  A61K35/33

CPC分类号： C07K14/8146 ,  A61K38/57 ,  A61K35/33

摘要： The present application discloses a membrane-type metalloprotease inhibitory protein T1PrαTACE and use thereof, which can be used for preparing drugs targeting MT1-MMP or TACE endonuclease. The present application discloses an antitumor pharmaceutical composition, comprising BHK-21 cells and an artificial basal membrane which expresses T1PrαTACE protein.

公开(公告)号：US20230149522A1

公开(公告)日：2023-05-18

申请号：US17915812

申请日：2021-03-29

申请人： PHARIS BIOTEC GMBH

发明人： Wolf-Georg Forssmann ,  Hans-Jürgen Mägert

IPC分类号： A61K38/57 ,  A61P31/14

CPC分类号： A61K38/57 ,  A61P31/14

摘要： Polypeptide having an amino acid sequence selected from at least 70% sequence identity to any one of domains 1 to 14 of LEKTI, SPINK6 or SPINK9-polypeptide for use in the treatment of a viral infection with a virus, in the infection of which serine proteinases are involved, and slowing down the spread of infection of said virus.

公开(公告)号：US11642384B2

公开(公告)日：2023-05-09

申请号：US17871805

申请日：2022-07-22

申请人： Krystal Biotech, Inc.

发明人： Pooja Agarwal ,  Suma Krishnan ,  John C. Freedman

IPC分类号： A61K35/763 ,  A61K38/17 ,  A61K38/39 ,  A61K48/00 ,  A61K9/00 ,  A61P17/02 ,  A61P17/04 ,  C12N5/071 ,  C12N9/02 ,  A61K38/57 ,  A61P17/00 ,  C12N15/52 ,  C12N15/86 ,  A61K9/06 ,  A61K47/38

CPC分类号： A61K35/763 ,  A61K9/0014 ,  A61K38/1748 ,  A61K38/39 ,  A61K38/57 ,  A61K48/005 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  C12N5/0629 ,  C12N9/0071 ,  C12N15/52 ,  C12N15/86 ,  A61K9/06 ,  A61K47/38 ,  C12N2710/16643 ,  C12Y114/11004

摘要： The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.

公开(公告)号：US20230113145A1

公开(公告)日：2023-04-13

申请号：US17969461

申请日：2022-10-19

申请人： OSIRIS THERAPEUTICS, INC.

发明人： Samson Tom ,  Alla Danilkovitch ,  Dana Yoo ,  Timothy Jansen ,  Jin-Qiang Kuang ,  Jennifer Michelle Marconi

IPC分类号： A61K35/28 ,  A01N1/02 ,  A61K35/50 ,  A61K38/18 ,  A61K38/39 ,  A61K38/57 ,  C12N5/073

摘要： Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

公开(公告)号：US20220378939A1

公开(公告)日：2022-12-01

申请号：US17832196

申请日：2022-06-03

申请人： Translate Bio, Inc.

发明人： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC分类号： A61K48/00 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K31/713 ,  A61K9/00 ,  A61K9/127 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52 ,  C12N15/85 ,  A61K9/51

摘要： Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20220370577A1

公开(公告)日：2022-11-24

申请号：US17296090

申请日：2019-11-22

申请人： Instituto Butantan

发明人： Ana Marisa Chudzinski Tavassi ,  Roger Chammas ,  Maurício Barbugiani Goldfeder ,  Carlos Deocesano Pereira ,  Flávio Linchtenstein ,  Jean Gabriel De Souza ,  Katia Luciano Pereira Morais

IPC分类号： A61K38/57

摘要： The invention falls within the fields of pharmaceutical sciences, immunology and methods of treatment of cancer Methods. More specifically, the invention relates to a compound for modulating one or more innate immune pathways selected from RLR, TLR, OAS and/or oncostatin M, said compound being amblyomin-×or peptides derived from amblyomin-X. Use of said compound for preparing medicines; a pharmaceutical composition comprising said compound, a method for modulating said pathways in vitro and a method of treatment are also described.

公开(公告)号：US20220323545A1

公开(公告)日：2022-10-13

申请号：US17640177

申请日：2020-09-02

申请人： AMGEN INC.

发明人： Hailing HSU

IPC分类号： A61K38/20 ,  A61K38/57 ,  A61K45/06

摘要： This invention provides compositions comprising a protein and an absorption enhancer, methods for treating inflammatory disorders, such as irritable bowel disease (IBD) comprising administering same, and methods for oral, intra-rectal, or other gut-related administration of a protein with an enzymatic activity, comprising orally, intra-rectally, or other gut-related administering same.

公开(公告)号：US11439611B2

公开(公告)日：2022-09-13

申请号：US16989148

申请日：2020-08-10

申请人： LEADING BIOSCIENCES, INC. ,  The Regents of the University of California

发明人： Geert W. Schmid-Schonbein ,  Yung-Tsai (Andrew) Lee ,  Jeng Wei

IPC分类号： A61K31/195 ,  A61K31/765 ,  A61K31/185 ,  A61K31/19 ,  A61K31/24 ,  A61K38/57 ,  A61K9/00 ,  A61K31/10 ,  A61K31/145 ,  A61K31/155 ,  A61K31/216 ,  A61K31/661 ,  A61K38/17 ,  A61K47/02 ,  A61K47/10 ,  A61K9/08

摘要： The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.

公开(公告)号：US20220265765A1

公开(公告)日：2022-08-25

申请号：US17738362

申请日：2022-05-06

申请人： BioAxone BioSciences, Inc.

发明人： Ricardo BORJAS ,  Mark FLEMING ,  Mei HUANG ,  Mayur JAIN ,  Tapan SANGHVI ,  Kumkum SAXENA ,  Amaris TORRES-DELGADO ,  Ping YIN ,  Lisa MCKERRACHER ,  Elizabeth RYU

IPC分类号： A61K38/17 ,  A61K38/36 ,  A61K38/38 ,  A61K38/57 ,  C07K14/47 ,  C12N9/10

摘要： The present invention provides, among other things, improved therapeutic compositions comprising a C3 fusion protein and methods of making and using the same. In particular, the present invention provides improved methods for the treatment of spinal cord injury and other CNS trauma and/or facilitate axon growth or other tissue repair.