公开(公告)号：US20200069541A1

公开(公告)日：2020-03-05

申请号：US16342563

申请日：2017-10-13

Applicant: SHISEIDO COMPANY, LTD.

Inventor： SHUN KUBOTA ,  Yurika WARANABE ,  Yuki SUGIYAMA

IPC: A61K8/06 ,  A61K8/02 ,  A61K8/73 ,  A61K8/81 ,  A61K8/86 ,  A61Q19/00

Abstract: The problem to be solved by the present invention is to provide an oil-in-water-type emulsion composition having an excellent sensation, particularly an excellent fresh sensation, upon use. An oil-in-water-type emulsion composition including oily phases and an aqueous phase having the oily phases dispersed therein, said emulsion composition being characterized in that a dispersant for dispersing the oily phases in the aqueous phase comprises: a core-corona-type microgel composed of hydrophobic gel microparticles and hydrophilic groups provided on parts of the surfaces of the hydrophobic gel microparticles; and an aqueous phase containing an agar microgel having an average particle diameter of 10 to 100 μm.

公开(公告)号：US20200057007A1

公开(公告)日：2020-02-20

申请号：US16345652

申请日：2017-10-26

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Tomonobu EZURE

IPC: G01N23/046 ,  G01N1/30 ,  G01N33/483

Abstract: The present invention addresses the problem of providing a method for observing skin tissue in which x-ray microCT is used. Adnexae such as sweat glands, sebaceous glands, and hair follicles can be identified in skin tissue by using acetone as a pretreatment solution and staining using an iodine-containing solution as a staining solution.

公开(公告)号：US20200000704A1

公开(公告)日：2020-01-02

申请号：US16450875

申请日：2019-06-24

Applicant: Shiseido Company, Ltd.

Inventor： Masato IINO ,  Nobuhiko OCHIAI ,  Makoto TSUNENAGA

IPC: A61K8/97 ,  A61Q19/08 ,  A61K8/67

Abstract: The present invention relates to providing a hyaluronidase inhibitor having a good hyaluronidase inhibiting activity. Specifically, the present invention provides with a hyaluronidase inhibitor comprising rosemary extract having a hyaluronidase inhibitory activity, and retinol acetate, which can enhances the hyaluronidase inhibitory activity of rosemary extract.

公开(公告)号：US20190380884A1

公开(公告)日：2019-12-19

申请号：US16334231

申请日：2017-09-19

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Akane MATSUSHITA ,  Tomohiro KUROKAWA ,  Emiko SUGA

IPC: A61F13/38 ,  A45D34/04 ,  A45D40/26 ,  A61F13/40

Abstract: The present invention provides an applicator used for applying viscous cosmetics such as lip gloss and viscous pharmaceutical preparations such as ointments, the applicator being sanitary and disposable but capable of reliably scooping the cosmetic or pharmaceutical preparation, coming into firm contact with the application area, and easily spreading the cosmetic or pharmaceutical preparation.Provided is an applicator 1 having a cotton body 3 that extends from an end portion of a shaft 2 and has a flat curved shape in which a maximum width W is 4.5 to 6.5 mm and a thickness T at a thickest portion is 2.0 to 3.6 mm, wherein an imaginary line 4 connecting a tip portion of the cotton body and a rear end central portion thereof has an inclination angle of 25 to 35 degrees with respect to the shaft 2.

公开(公告)号：US20190339281A1

公开(公告)日：2019-11-07

申请号：US16231381

申请日：2018-12-21

Applicant: Shiseido Company, Ltd.

Inventor： Kenji HAMASE ,  Yurika MIYOSHI ,  Masashi MITA

IPC: G01N33/68

Abstract: The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

公开(公告)号：US10456337B2

公开(公告)日：2019-10-29

申请号：US15207069

申请日：2016-07-11

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Noriko Tomita ,  Reiji Miyahara ,  Hiroyuki Kakoki

IPC: A61K8/06 ,  A61K8/891 ,  A61Q1/06 ,  A61K8/36 ,  A61K8/25 ,  A61K8/31 ,  A61K8/73

Abstract: The present invention provides an oil-in-oil type cosmetic composition that has excellent transfer resistance after application, a luster, favorable spreadability during application, and also excellent stability. The oil-in-oil type cosmetic composition comprises (a) 5 to 80% by mass of non-volatile hydrocarbon oil, (b) 1 to 70% by mass of non-volatile silicone oil, and (c) 0.1 to 10% by mass of dextrin fatty acid ester. Preferably, the non-volatile hydrocarbon oil (a) and the non-volatile silicone oil (b) are formulated at a ratio (mass ratio) of (a)/[(a)+(b)]=0.4 to 0.8.

公开(公告)号：US20190321282A1

公开(公告)日：2019-10-24

申请号：US16474096

申请日：2017-12-13

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yukiko SATO ,  Tomoko A IKED

IPC: A61K8/891 ,  A61K8/31 ,  A61K8/73 ,  A61Q17/04 ,  A61Q1/00 ,  A61K8/44 ,  A61K8/06

Abstract: A low-viscosity water-in-oil cosmetic emulsion preparation gives a smooth use feeling, lightly spreads when applied, and has excellent dispersed-powder stability. The cosmetic emulsion preparation has (A) a polar oil which is liquid at 25° C. and has an IOB value exceeding 0.1, (B) a hydrocarbon oil, (C) a polyoxyalkylene; and alkyl-modified organopolysiloxane represented by general formula (I), and (D) a powder surface-treated with both an N-acylamino acid and methylpolysiloxane. (In formula (I), R represents a hydrogen atom or a C1-5 alkyl group, x is an integer of 5-50, y is an integer of 1-30, z is an integer of 20-200, a is an integer of 2-20, b is an integer of 1-5, c is an integer of 2-20, and d is an integer of 0-20.)

公开(公告)号：US20190300953A1

公开(公告)日：2019-10-03

申请号：US16412993

申请日：2019-05-15

Applicant: Shiseido Company, Ltd

Inventor： Yosuke TOJO ,  Masato IINO ,  Chieko MIZUMOTO ,  Yuzo YOSHIDA ,  Yuko MATSUURA ,  Hisashi MORI

IPC: C12Q1/6876 ,  A61K36/28 ,  C12Q1/6883 ,  A61K36/899 ,  A61Q19/00 ,  A61K8/97 ,  A61K8/64 ,  G01N33/50 ,  G01N33/68 ,  A61K36/9068 ,  A61K38/01

Abstract: The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

公开(公告)号：US20190275094A1

公开(公告)日：2019-09-12

申请号：US16343749

申请日：2017-10-20

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Shunsuke IRIYAMA ,  Saori TANNO

IPC: A61K36/03 ,  C12N9/50 ,  C12N9/24 ,  A61P29/00 ,  G01N33/50

Abstract: The purpose of this invention is to provide a method with which it is easy to perform screening for an agent that proliferates or an agent that minimizes the reduction in MCSP-positive basal epidermal stem cells. Provided is a screening method for a laminin 511 expression promoter, which takes the expression of laminin 511 as an indicator. Also provided is an agent for improving skin barrier function, elasticity, hydration and inflammation, said agent including at least one extract selected from among a group consisting of brown algae, red algae and green algae.

公开(公告)号：US20190269598A1

公开(公告)日：2019-09-05

申请号：US16344997

申请日：2017-10-27

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Yusuke YABUSAKI

IPC: A61K8/81 ,  A61K8/06 ,  A61K8/31 ,  A61Q19/00

Abstract: An oil-in-water emulsion composition for skin includes 0.2 to 2.5% by mass of polyisobutene having a relative mass in a range of 30,000 to 100,000. The composition is applied to skin except for a lip.