公开(公告)号：US20160002210A1

公开(公告)日：2016-01-07

申请号：US14770035

申请日：2014-02-27

Applicant: ARRAY BIOPHARMA INC.

Inventor： Todd C. Eary ,  Bruno P. Hache ,  Derrick Juengst ,  Stacey Renee Spencer ,  Peter J. Stengel ,  Daniel John Watson

IPC: C07D403/12 ,  C07D231/56

CPC classification number: C07D403/12 ,  C07D231/56

Abstract: Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

Abstract translation: 本文提供了制备式（I）化合物以在合成吲唑衍生物的新方法中使用所述化合物作为中间体的新方法，以及通过本文所述的方法制备的吲唑中间体和衍生物。

公开(公告)号：US09102639B2

公开(公告)日：2015-08-11

申请号：US14099276

申请日：2013-12-06

Applicant: ARRAY BIOPHARMA INC.

Inventor： Jeremy Hans ,  Eli M. Wallace ,  Qian Zhao ,  Joseph P. Lyssikatos ,  Thomas D. Aicher ,  Ellen R. Laird ,  John Robinson ,  Shelley Allen

IPC: C07D285/12 ,  C07D271/107 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D401/12

CPC classification number: C07D285/12 ,  C07D271/107 ,  C07D401/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07F9/201 ,  C07F9/65392

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：US09096567B2

公开(公告)日：2015-08-04

申请号：US14231356

申请日：2014-03-31

Applicant: Array BioPharma Inc.

Inventor： Laurence E. Burgess ,  Christopher T. Clark ,  Adam Cook ,  Christopher P. Corrette ,  Robert Kirk DeLisle ,  George A. Doherty ,  Kevin W. Hunt ,  Todd T. Romoff ,  Ganghyeok Kim

IPC: A61K31/352 ,  C07D311/04 ,  C07D311/58 ,  C07D405/12 ,  C07D407/12

CPC classification number: C07D311/58 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

Abstract: Provided herein is a method of treating an allergic inflammatory disease selected from asthma, dermatitis, allergic rhinitis, urticaria, anaphylaxis, angioedemea, allergies, contact hypersensitivity, drug hypersensitivity, and allergic conjunctivitis in a mammal, comprising administering a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, to said mammal in need thereof, wherein A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 are as defined herein.

Abstract translation: 本文提供了一种治疗哺乳动物中选自哮喘，皮炎，过敏性鼻炎，荨麻疹，过敏反应，血管紧张素，过敏，接触超敏反应，药物过敏和过敏性结膜炎的过敏性炎性疾病的方法，其包括给予治疗有效量的化合物 其中A1，A2，W，L，G，R7a，R7b，R8，R9和R10如本文所定义。

公开(公告)号：US20150152067A1

公开(公告)日：2015-06-04

申请号：US14401087

申请日：2013-05-17

Applicant: Array BioPharma Inc. ,  Genentech, Inc.

Inventor： David Askin ,  Chong Han ,  Jonathan W. Lane ,  Travis Remarchuk ,  Sagar Shakya ,  C. Gregory Sowell ,  Keith L. Spencer ,  Peter J. Stengel

IPC: C07D239/42 ,  C07D239/70

CPC classification number: C07D239/42 ,  C07D239/30 ,  C07D239/70 ,  C07D403/04

Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.

Abstract translation: 本发明提供制备式I化合物及其盐的方法，其中R 1在本文中定义，以及所述式的化合物和中间体。

公开(公告)号：US20150110780A1

公开(公告)日：2015-04-23

申请号：US14387533

申请日：2013-03-25

Applicant: Array BioPharma Inc.

Inventor： Patrice A. Lee ,  Shannon L. Winski ,  Kevin Koch

IPC: A61K31/517 ,  A61K45/06

CPC classification number: A61K31/517 ,  A61K31/337 ,  A61K31/7068 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  A61K2300/00

Abstract: Compounds for the treatment of brain cancer are provided herein. Pharmaceutical compositions comprised of those compounds for the treatment of brain cancer are also provided herein.

Abstract translation: 本文提供了用于治疗脑癌的化合物。 本文还提供了由那些用于治疗脑癌的化合物组成的药物组合物。

公开(公告)号：US20150031667A1

公开(公告)日：2015-01-29

申请号：US14321246

申请日：2014-07-01

Applicant: Array BioPharma Inc.

Inventor： Shelley Allen ,  Steven Wade Andrews ,  Kevin Ronald Condroski ,  Julia Haas ,  Lily Huang ,  Yutong Jiang ,  Timothy Krecher ,  Jeongbeob Seo

IPC: C07D487/04 ,  C07D453/02

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  C07D453/02 ,  C07D471/22 ,  C07D498/22 ,  C07D519/00

Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

Abstract translation: 式Ⅰ化合物及其盐，其中R1，R2，R3，R4，X，Y和n具有本说明书中给出的含义，是Trk激酶的抑制剂，可用于治疗可用 Trk激酶抑制剂如疼痛，癌症，炎症，神经变性疾病和某些传染病。

公开(公告)号：US08895550B2

公开(公告)日：2014-11-25

申请号：US14054459

申请日：2013-10-15

Applicant: Array BioPharma Inc.

Inventor： Shelley Allen ,  Robert Kirk DeLisle ,  Julie Marie Hicks ,  Erik James Hicken ,  Joseph P. Lyssikatos ,  Fredrik P. Marmsater ,  Mark C. Munson ,  John E. Robinson ,  Qian Zhao

IPC: A61K31/437 ,  A61K31/4353 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein are methods of treating diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases by administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula I: in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification.

Abstract translation: 本文提供了通过向有需要的哺乳动物施用治疗有效量的式I化合物来治疗由PIM-1和/或PIM-2和/或PIM-3激酶介导的疾病的方法：其中B，R1， R1a，R2，R3，R4，R5，R6，R7，R10和R11具有说明书中给出的含义。

公开(公告)号：US20140315887A1

公开(公告)日：2014-10-23

申请号：US14321468

申请日：2014-07-01

Applicant: Array BioPharma Inc. ,  Genentech, Inc.

Inventor： Josef R. Bencsik ,  James F. Blake ,  Nicholas C. Kallan ,  Ian S. Mitchell ,  Keith L. Spencer ,  Dengming Xiao ,  Rui Xu ,  Christine Chabot ,  Jun Liang ,  Brian S. Safina

IPC: C07D409/12 ,  C07D403/12 ,  C07D239/70

CPC classification number: C07D239/70 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12

Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US20140221342A1

公开(公告)日：2014-08-07

申请号：US14231356

申请日：2014-03-31

Applicant: Array BioPharma Inc.

Inventor： Laurence E. Burgess ,  Christopher T. Clark ,  Adam Cook ,  Christopher P. Corrette ,  Robert Kirk DeLisle ,  George A. Doherty ,  Kevin W. Hunt ,  Todd T. Romoff ,  Ganghyeok Kim

IPC: C07D311/58 ,  C07D407/12 ,  C07D405/12

CPC classification number: C07D311/58 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

Abstract: Provided herein is a method of treating an allergic inflammatory disease selected from asthma, dermatitis, allergic rhinitis, urticaria, anaphylaxis, angioedemea, allergies, contact hypersensitivity, drug hypersensitivity, and allergic conjunctivitis in a mammal, comprising administering a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, to said mammal in need thereof, wherein A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 are as defined herein.

Abstract translation: 本文提供了一种治疗哺乳动物中选自哮喘，皮炎，过敏性鼻炎，荨麻疹，过敏反应，血管紧张素，过敏，接触超敏反应，药物过敏和过敏性结膜炎的过敏性炎性疾病的方法，包括给予治疗有效量的化合物 其中A1，A2，W，L，G，R7a，R7b，R8，R9和R10如本文所定义。

公开(公告)号：US20140142086A1

公开(公告)日：2014-05-22

申请号：US14016951

申请日：2013-09-03

Applicant: ARRAY BIOPHARMA, INC. ,  VENTIRX PHARMACEUTICALS, INC.

Inventor： James Jeffry Howbert ,  Gregory Dietsch ,  Robert M. Hershberg ,  Laurence E. Burgess ,  George A. Doherty ,  C. Todd Eary ,  Robert D. Groneberg ,  Zachary Jones

IPC: C07D403/14 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D401/14

CPC classification number: C07D223/16 ,  A61K31/4025 ,  A61K31/55 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.