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公开(公告)号：US6066776A
公开(公告)日：2000-05-23
申请号：US895050
申请日：1997-07-16
CPC分类号： A61F2/0063 , Y10S623/901
摘要： A prosthesis is provided that is advantageously used to fill a soft tissue or muscle defect, such as an inquinal or femoral hernia. In a first aspect of the invention, multiple layers of a flexible, mesh material are attach together at a finite number of joins. A tab is placed at the geometric center of one of the mesh layers to facilitate insertion of the mesh into the defect. The tab also creates a blunt tip that reduces irritation and discomfort to the patient. In a second aspect of the invention, a prosthesis is provided that includes a barrier layer between two or more layers of flexible, mesh material to prevent adhesion of the device to the tissue. All layers are attached together by a finite number of joins. A tab is placed at the geometric center of one of the mesh layers to facilitate insertion of the mesh into the defect. The prostheses of the invention are self-forming in that they change from a two dimensional configuration to a three dimensional configuration upon insertion of the device into the defect.
摘要翻译： 提供了一种假体，其有利地用于填充软组织或肌肉缺损，例如询问或股骨疝。 在本发明的第一方面中，柔性网状材料的多层以有限数量的连接连接在一起。 在一个网格层的几何中心处放置一个突片，以便于将网格插入到缺陷中。 该标签还创建一个钝头，减少患者的刺激和不适。 在本发明的第二方面中，提供一种假体，其包括两层或多层柔性网状材料之间的阻挡层，以防止该装置粘附到组织上。 所有层通过有限数量的连接连接在一起。 在一个网格层的几何中心处放置一个突片，以便于将网格插入到缺陷中。 本发明的假体是自形成的，因为它们在将装置插入缺陷时从二维构型变为三维构型。
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公开(公告)号：US5807358A
公开(公告)日：1998-09-15
申请号：US472144
申请日：1995-06-07
申请人： Steve A. Herweck , Theodore Karwoski , David Cross
发明人： Steve A. Herweck , Theodore Karwoski , David Cross
CPC分类号： A61M1/3627 , A61M1/0013 , A61M1/0031 , A61M1/0033
摘要： A blood collection device has a modular suction regulator assembly in the form of an adjustable negative pressure relief valve which controls the level of suction in a collection chamber by admitting air to a short bleed-in passage proximate to a suction connection. The modular assembly is a canister which drops into a receptacle oriented transversely in the collection vessel, and defines a laterally-directed intake manifold which resists blockage. The intake passes centrally through the canister along a path spanned by a filter, past a hat-shaped poppet supported on a compression spring. Fluted and threaded members control the scale and range of poppet response so that the assembly may be calibrated before installation. A face plate covers the installed canister, and radial vanes in the intake manifold double as gripping elements for manual adjustment of the assembly. A bellows meter provides refined suction resolution by linearly advancing across an oblique or curved reference line. Other improvements include a compact and balanced layout of suction canister, seal chamber and collection chamber, and a rigid handle assembly having five faces integral with the device.
摘要翻译： 血液采集装置具有可调式负压释放阀形式的模块式抽吸调节器组件，其通过将空气接近靠近抽吸连接处的短的通入通道来控制收集室中的抽吸水平。 模块化组件是一种罐，该罐可以放入收集容器中横向定向的容器中，并限定一个防止阻塞的横向定向的进气歧管。 进气口沿着由过滤器跨过的路径中心穿过罐体，经过支撑在压缩弹簧上的帽形提升阀。 槽形和螺纹构件控制提升阀响应的尺寸和范围，以便在安装之前校准组件。 面板覆盖安装的罐，并且进气歧管中的径向叶片作为用于手动调节组件的夹紧元件加倍。 波纹管表通过线性前进穿过斜线或弯曲参考线提供精确的吸力分辨率。 其他改进包括吸盘，密封腔和收集室的紧凑平衡的布局，以及具有与该装置一体的五个面的刚性手柄组件。
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公开(公告)号：US5722964A
公开(公告)日：1998-03-03
申请号：US487468
申请日：1995-06-07
CPC分类号： A61M1/0013 , A61M1/0031 , A61M1/0033 , A61M1/3627
摘要： A blood collection vessel includes a blood inlet, a pooling region in which blood from the inlet collects, and an outlet in the pooling region for reinfusion of the collected blood. A filter located in the blood path between inlet and outlet extends at least in part into the pooling region and impounds clots so they remain away from the outlet but suspended in the collected blood. Preferably, the filter is located to provide venting between both sides of the filter. In one embodiment the filter is a vertical wall, which defines a shielded outlet column or chimney extending above the outlet. Blood permeates to the outlet region over a broad area, and the column forms an open suction path that prevents suction differentials from arising across the filter, so clots cannot be sucked through the large-pore material. With the clots residing in the collected fluid, the total fluid loss is directly displayed in a single window at all times, and maximal use is made of the limited volume in the vessel. In another embodiment, the filter constitutes a false floor or basket in the pooling region. A preferred construction employs filter material on a support grid, to form a flexible and self-supporting filter sheet, which inserts like a plate to compartmentalize the collection vessel and form an impounding surface in the pooling region.
摘要翻译： 血液采集容器包括血液入口，来自入口的血液收集的汇集区域以及汇集区域中用于回收血液回输的出口。 位于入口和出口之间的血液路径中的过滤器至少部分地延伸到汇集区域中并扣留凝块，使得它们保持远离出口但悬浮在收集的血液中。 优选地，过滤器被定位成在过滤器的两侧之间提供排气。 在一个实施例中，过滤器是垂直壁，其限定在出口上方延伸的屏蔽出口塔或烟囱。 血液在大面积上渗透到出口区域，柱形成一个开放的吸入路径，防止吸入差异跨越过滤器，因此凝块不能通过大孔材料吸入。 在收集的液体中存在凝块的情况下，总的流体损失始终直接显示在单个窗口中，并且最大限度地利用了容器中有限的体积。 在另一个实施例中，过滤器构成汇集区域中的假地板或篮子。 优选的结构是在支撑格栅上使用过滤材料，以形成柔性和自支撑的过滤片，其将类似板的插入物分隔成收集容器并在汇集区域中形成蓄水表面。
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34.发明授权
公开(公告)号：US5474824A
公开(公告)日：1995-12-12
申请号：US268240
申请日：1994-06-29
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , B29C47/00 , B29C55/00 , B29C69/00 , B29D23/00 , B29K27/12 , B29K105/04 , D02J1/06
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/56 , B01D67/0027 , B01D69/02 , B01D69/12 , B01D71/36 , B29C47/0004 , B29C47/0021 , B29C55/005 , B01D2325/02 , B29C47/0023 , B29C47/0026 , B29C47/0042 , B29C47/0057 , B29C47/062 , B29C47/065 , B29K2027/18 , B29K2105/04 , B29L2023/005 , B29L2023/007 , Y10T428/139 , Y10T428/1397 , Y10T428/24273 , Y10T428/249986 , Y10T428/24999 , Y10T428/249992 , Y10T428/31544
摘要： A process for producing a shaped porous article includes the steps of providing an extrudate of a fluoropolymer material which is capable of being stretched and bilaterally stretching the extrudate along a longitudinal axis. The stretching step is carried out under conditions sufficient to yield an article which is substantially uniformly stretched over a major portion of its length. After stretching, the material has a unique through-pore microstructure characterized by elongate nodes connected by fibrils. The stretched material is sintered while being maintained in its stretched state to produce the shaped porous article. A significant feature of the inventive process is that stretching is carried out by displacing both ends of the extruded material as opposed to known method wherein only one end of an extruded material is stretched, resulting in a microporous fluoropolymer article which are different than conventional fluoropolymer stretching/expansion processes.
摘要翻译： 一种生产成形多孔制品的方法包括以下步骤：提供含氟聚合物材料的挤出物，该挤出物能够沿着纵向轴线被拉伸和双向拉伸挤出物。 拉伸步骤在足以产生在其长度的主要部分上基本上均匀拉伸的制品的条件下进行。 拉伸后，该材料具有独特的通孔微结构，其特征在于由原纤维连接的细长节点。 拉伸的材料在保持拉伸状态下被烧结以产生成形的多孔制品。 本发明方法的一个重要特征是通过使挤出材料的两端位移来进行拉伸，与已知方法相反，其中仅挤出材料的一端被拉伸，得到与常规含氟聚合物拉伸不同的微孔含氟聚合物制品 /扩展过程。
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公开(公告)号：US5141504A
公开(公告)日：1992-08-25
申请号：US385823
申请日：1989-07-26
IPC分类号： A61M1/00
CPC分类号： A61M1/0013 , A61M1/0056 , A61M2205/3348 , A61M2205/59
摘要： A drainage device includes a vessel having a plurality of sub-chambers one of which is a regulated drainage collection chamber, and two of which cooperate to maintain a selected suction level in the drainage collection chamber. A stopcock proximate to the vessel communicates directly with the two cooperating sub-chambers, and allows quick adjustment and stable operation in varying environments. A float ball arrangement provides an indication of water loss that may compromise the water seal. The device is suitable for wound drainage, and may be used as a cardiotomy reservoir or a thoracic cavity drain device. Different embodiments collect blood for autologous infusion.
摘要翻译： 排水装置包括具有多个子室的容器，其中一个是受调节的排水收集室，其中两个辅助以在排液收集室中保持选定的吸入水平。 靠近船舶的旋塞阀与两个协作的子舱直接通信，并且允许在不同的环境中进行快速调节和稳定的操作。 浮球布置提供可能损害水封的失水指示。 该装置适用于伤口引流，可用作心脏切开术储存器或胸腔排液装置。 不同的实施例收集用于自体输注的血液。
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公开(公告)号：USD328790S
公开(公告)日：1992-08-18
申请号：US253739
申请日：1988-10-05
申请人： Steve A. Herweck , Steven M. Vail
设计人： Steve A. Herweck , Steven M. Vail
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公开(公告)号：US11213652B2
公开(公告)日：2022-01-04
申请号：US16451835
申请日：2019-06-25
发明人： Steve A. Herweck , Ronit R. Furman
IPC分类号： A61M25/00 , A61B5/00 , A61M25/01 , A61M5/00 , A61B6/12 , A61B34/20 , A61B5/055 , A61B8/08 , A61B90/00 , A61B6/00
摘要： A method and apparatus for fluid delivery enables navigation through tortuous, spatially restricted body anatomy to access narrow diameter body lumens for the continuous delivery of fluids, including therapeutic fluids, to the lumen in an atraumatic manner that avoids damage to the body lumen. The fluid delivery device can have a flexible conduit having a proximal end, a distal end, and a lumen extending along an interior of the flexible conduit providing a fluid flow path between the proximal and distal ends, where the lumen transitions into a micro-lumen exiting through a port through which a high concentration of fluid injected into the lumen exits laterally out along an image viewable zone at the distal end of the flexible conduit. The flexible conduit has a maximum outer diameter sized sufficient to navigate narrow diameter body lumens.
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公开(公告)号：US10814043B2
公开(公告)日：2020-10-27
申请号：US15794086
申请日：2017-10-26
发明人： Keith M. Faucher , Hui Tang , Paul Martakos , Theodore Karwoski , Alison Sullivan , Greg Melville , Scott E. Corbeil
IPC分类号： A61L31/08 , A61L31/16 , A61K31/4353 , A61L31/14 , A61F2/82
摘要： Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
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公开(公告)号：US10792312B2
公开(公告)日：2020-10-06
申请号：US15710514
申请日：2017-09-20
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Phillip McNamara
IPC分类号： A61K35/60 , A61F13/02 , A61K9/00 , A61K31/355 , A61L2/07 , A61L2/08 , A61L2/20 , A61L31/00 , A61L27/36 , A61L27/54 , A61K9/06 , A61K31/225 , A61K47/12 , A61K47/14 , A61L31/10 , A61L31/14 , A61L27/52 , A61K38/13 , A61F2/06 , B05D3/06
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
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公开(公告)号：US10603153B2
公开(公告)日：2020-03-31
申请号：US14948844
申请日：2015-11-23
摘要： A hernia patch supporting tissue in-growth conforms to a tissue wall upon surgical installation and fixation within a patient. The hernia patch can include a base and positioning straps. The base is formed of two layers that are affixed to each other around the perimeter of the patch, for example by stitching. A stabilizing washer is provided between the two layers, and the stitch is provided peripherally around the stabilizing washer, keeping the washer free-floating between the layers. The base, positioning straps, and stabilizing washer are formed of a structure that does not separate the layers of the implant or form a space in the form of a pocket, and promotes more uniform and confluent tissue incorporation or in-growth after implantation. The hernia patch may further include a hydrolysable bioabsorbable cross-linked coating of a fatty acid based material, such as an omega-3 fatty acid based material.
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