公开(公告)号：US11363822B2

公开(公告)日：2022-06-21

申请号：US16389147

申请日：2019-04-19

Applicant: Academia Sinica

Inventor： Yet-Ran Chen ,  Ying-Lan Chen ,  Mei-Chun Tseng

IPC: A61K38/00 ,  A61K38/01 ,  A61K38/03 ,  A61K38/04 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  C07K14/00 ,  A01N65/38 ,  C07K14/415 ,  C12N15/82

Abstract: The present invention is related to a novel plant defense signaling peptide and applications thereof.

公开(公告)号：US11357788B2

公开(公告)日：2022-06-14

申请号：US16355545

申请日：2019-03-15

Applicant: ACADEMIA SINICA

Inventor： Hung-Chih Kuo ,  Yi-Ying Wu

IPC: A61K31/7105 ,  A61P25/16 ,  A61P25/28

Abstract: The present disclosure provides a method of reducing neurodegeneration and/or TDP43 associated aggregation, comprising knocking down the expression of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) or LncRNA NEAT1. Also provided are methods for screening a candidate agent that reduces neurodegeneration and/or TDP43 associated aggregation in a cell, treating or preventing a neurodegenerative disorder, delaying or preventing the onset of a neurodegenerative disorder or reducing a risk for developing a neurodegenerative disorder in a subject and determining whether a subject is suffering from, or at a risk of developing a neurodegenerative disorder, comprising measuring the presence of cytoplasmic NEAT1 in a biological sample, wherein the presence is indicative of the risk of developing a neurodegenerative disorder.

公开(公告)号：US11311592B2

公开(公告)日：2022-04-26

申请号：US16799158

申请日：2020-02-24

Applicant: Academia Sinica ,  Industrial Technology Research Institute

Inventor： Chang-Jen Huang ,  Rita P.-Y. Chen ,  Yung-Feng Liao ,  Bo-Kai Wu ,  Po-Ting Chen ,  Hui-Ping Tsai ,  Yi-Cheng Cheng ,  Cheng-Li Fang ,  Hung-Chi Chien ,  Tien-Soung Tong ,  Ting-Shou Chen ,  Shu-Jiau Chiou

IPC: B01D11/02 ,  A61K36/48 ,  A61P25/28 ,  A61K9/00

Abstract: Disclosed herein is the novel use of use of a Bauhinia spp. extract, which may upregulate neprilysin, induce autophagy, protect neuron from amyloidopathy or tauopathy, and/or promote neurite outgrowth, thus the Bauhinia spp. extract of the present disclosure may be used as a dietary supplement for the prophylaxis or treatment of amyloid related neurodegenerative diseases so as to ameliorate or alleviate symptoms associated with the amyloid related neurodegenerative diseases.

公开(公告)号：US11299744B2

公开(公告)日：2022-04-12

申请号：US15838702

申请日：2017-12-12

Applicant: Academia Sinica

Inventor： Su-May Yu ,  Chun-Hsien Lu ,  Tuan-Hua David Ho ,  Shuen-Fang Lo

IPC: C12N15/82 ,  C12N9/16

Abstract: The present disclosure relates to transgenic plants that over-express PP2CABA and methods of using such for enhancing osmotic stress tolerance.

公开(公告)号：US20220100985A1

公开(公告)日：2022-03-31

申请号：US17427086

申请日：2020-05-08

Applicant: Academia Sinica

Inventor： Yi-Sheng WANG ,  Chih-Hao HSIAO

IPC: G06K9/00

Abstract: Disclosed herein are methods and apparatus for reducing errors in spectroscopic measurements. The present method minimizes errors by aligning peak positions and recalculating intensities in every single-scan spectrum with reference to spectral features observed in the spectrum integrating all uncorrected single-scan spectra. Additionally, the corrected single-scan spectra are integrated to improve the resolving power, signal intensity and peak shape.

公开(公告)号：US20220090023A1

公开(公告)日：2022-03-24

申请号：US17418619

申请日：2019-12-26

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Wei-Ju CHEN

IPC: C12N5/074 ,  C12N5/00 ,  C12N15/86 ,  C12N15/873 ,  C12N15/85 ,  C07K14/435

Abstract: The present invention relates to a method for regulating potency of pluripotent stem cells (PSCs) by modulating expression of podocalyxin-like protein 1 (PODXL) and applications thereof.

公开(公告)号：US11264601B2

公开(公告)日：2022-03-01

申请号：US16189005

申请日：2018-11-13

Applicant: National Chi Nan University ,  Academia Sinica

Inventor： Horng-Yi Tang ,  Maw-Kuen Wu ,  Yan-Ting Chen ,  Prem Chandan Devanga

IPC: H01M4/04 ,  H01M10/0525 ,  H01M4/485

Abstract: A method for making a vanadium pentoxide-based active material for a cathode of an alkali metal ion battery includes steps of: a) preparing an aqueous solution of a triazine derivative of Formula (I) wherein each R independently represents hydrogen or an amino group; and b) adding vanadium pentoxide to the aqueous solution of the triazine derivative under stirring, so as to permit condensation among hydrolyzed vanadium pentoxide along with self-assembly of the triazine derivatives to obtain a reaction solution containing the active material.

公开(公告)号：US20210361706A1

公开(公告)日：2021-11-25

申请号：US17269612

申请日：2019-08-28

Applicant: ACADEMIA SINICA

Inventor： Nan-Shih LIAO ,  Shih-Wen HUANG ,  Zhen-Qi WU ,  Yein-Gei LAI ,  Yae-Huei LIOU

IPC: A61K35/17 ,  A61K31/675 ,  A61P35/00

Abstract: Combined therapy of cancer (e.g., breast cancer) involving a cyclophosphamide compound and natural killer (NK) cells. Also provided herein are methods for inducing immune memory and/or reducing the risk of tumor recurrence using the combined therapy of a cyclophosphamide compound and NK cells.

公开(公告)号：US20210315966A1

公开(公告)日：2021-10-14

申请号：US17265090

申请日：2019-07-30

Applicant: Academia Sinica

Inventor： Che-Ming Jack Hu ,  Yu-Han Liu ,  Te-Li Chen

IPC: A61K38/12 ,  A61K9/16 ,  A61P31/04

Abstract: A therapeutic nanoparticle containing a cationic polypeptide and a polyanionic molecule, in which the cationic polypeptide, exerting antibacterial activity, forms electrostatic interaction with the polyanionic molecule, and the therapeutic nanoparticle has a diameter of less than 50 nm. Also disclosed are a pharmaceutical composition, a treatment method, and a preparation method, all related to the therapeutic nanoparticle.

公开(公告)号：US20210292438A1

公开(公告)日：2021-09-23

申请号：US17340102

申请日：2021-06-07

Applicant: ACADEMIA SINICA

Inventor： Steve ROFFLER ,  Tian-Lu Cheng ,  Yu-Cheng Su ,  Kuo-Hsiang Chuang

IPC: C07K16/44 ,  A61K47/60 ,  A61K47/69 ,  A61P35/00 ,  A61K31/55 ,  A61K31/704 ,  A61K51/06 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  G01N33/574

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also disclosed is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. Further disclosed is a method for diagnosing a cell-mediated disorder by administering a PEG engager followed by a PEGylated diagnostic agent.