公开(公告)号：US20210311037A1

公开(公告)日：2021-10-07

申请号：US17349682

申请日：2021-06-16

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N33/543 ,  G01N33/50 ,  G01N21/77 ,  G01N33/53

Abstract: Two or more upconverting particles are attached to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-particle complex including the unit of the chemical component and two or more corresponding upconverting particles. The sample is illuminated by input light having a first wavelength. Light is received at an imaging sensor, the received light including output light generated by at least a portion of the upconverting particles attached to the units of the chemical component, the output light having a second wavelength that is shorter than the first wavelength. One or more images of the sample are captured from the received light. Based on the captured one or more images, a presence or a level of the chemical component in the sample is determined.

公开(公告)号：US10991744B2

公开(公告)日：2021-04-27

申请号：US17070743

申请日：2020-10-14

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Madhuranga Srinath Rankaduwa

IPC: G01N33/49 ,  H01L27/146 ,  G01N21/27 ,  G02B21/00

Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.

公开(公告)号：US20210063713A1

公开(公告)日：2021-03-04

申请号：US17085389

申请日：2020-10-30

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Peter Hodges Gregson

IPC: G02B21/00

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

公开(公告)号：US20200256889A1

公开(公告)日：2020-08-13

申请号：US16820904

申请日：2020-03-17

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01Q60/20 ,  H01L27/146 ,  G02B21/36 ,  G02B21/00 ,  G01N21/64

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

公开(公告)号：US10684278B1

公开(公告)日：2020-06-16

申请号：US16368707

申请日：2019-03-28

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N21/77 ,  G01N33/543 ,  G01N33/50 ,  G01N33/53

Abstract: Among other things, two or more different antibodies are caused to bind to one or more units of a chemical component in a sample. Each of the antibodies is attached to one or more beads (e.g., microbeads). The sample is situated on a surface of an image sensor. At the image sensor, light is received originating at a light source that is other than the beads. The received light includes light reflected by, refracted by, or transmitted through the beads. The image sensor captures one or more images of the sample including the beads. At least one of the images of the sample is processed to separately enumerate individual beads and complexes of two or more of the beads attached to the two or more antibodies that are bound to a unit of the chemical component. The results of the processing are used to identify a presence or a level of the chemical component in the sample.

公开(公告)号：US10461112B1

公开(公告)日：2019-10-29

申请号：US16282501

申请日：2019-02-22

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Madhuranga Srinath Rankaduwa

IPC: H01L27/146 ,  G01N21/27 ,  G01N33/49

Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.

公开(公告)号：US20190324239A1

公开(公告)日：2019-10-24

申请号：US16439333

申请日：2019-06-12

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Peter Hodges Gregson

IPC: G02B21/00

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

公开(公告)号：US20190293524A9

公开(公告)日：2019-09-26

申请号：US15066065

申请日：2016-03-10

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Hershel Macaulay

IPC: G01N1/28 ,  G01N1/38 ,  G01N33/49 ,  G02B21/36 ,  G01N21/31

Abstract: Among other things, a diluted sample is generated based on mixing a small sample of blood with a one or more diluents. A thin film of the diluted sample is formed on the surface of a contact optical microscopy sensor. Red blood cells within a portion of the thin film of the diluted sample are illuminated using light of a predetermined wavelength. One or more images of the diluted sample are acquired based on illuminating the red blood cells within the portion of the thin film of the diluted sample. The acquired one or more images of the diluted sample are then processed. The mean corpuscular hemoglobin in the red blood cells within the portion of the thin film of the diluted sample is determined based on processing the acquired images of the diluted sample.

公开(公告)号：US10249669B1

公开(公告)日：2019-04-02

申请号：US16210098

申请日：2018-12-05

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Madhuranga Srinath Rankaduwa

IPC: G01N33/49 ,  H01L27/146 ,  G01N21/27

Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.

公开(公告)号：US20190094509A1

公开(公告)日：2019-03-28

申请号：US16113578

申请日：2018-08-27

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Peter Hodges Gregson

IPC: G02B21/00

CPC classification number: G02B21/0008

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.