公开(公告)号：US11733239B2

公开(公告)日：2023-08-22

申请号：US17674967

申请日：2022-02-18

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N21/41 ,  G01N21/55 ,  G01N21/59 ,  G01N33/543 ,  G01N33/569 ,  G01N21/17

CPC classification number: G01N33/54313 ,  G01N21/41 ,  G01N21/55 ,  G01N21/59 ,  G01N33/56983 ,  G01N2021/1772

Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.

公开(公告)号：US11598699B2

公开(公告)日：2023-03-07

申请号：US16994124

申请日：2020-08-14

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Hershel Macaulay

IPC: G01N1/28 ,  G01N1/38 ,  G01N33/49 ,  G02B21/36 ,  G01N21/31 ,  G02B21/00

Abstract: Among other things, a diluted sample is generated based on mixing a small sample of blood with a one or more diluents. A thin film of the diluted sample is formed on the surface of a contact optical microscopy sensor. Red blood cells within a portion of the thin film of the diluted sample are illuminated using light of a predetermined wavelength. One or more images of the diluted sample are acquired based on illuminating the red blood cells within the portion of the thin film of the diluted sample. The acquired one or more images of the diluted sample are then processed. The mean corpuscular hemoglobin in the red blood cells within the portion of the thin film of the diluted sample is determined based on processing the acquired images of the diluted sample.

公开(公告)号：US11255850B2

公开(公告)日：2022-02-22

申请号：US16845458

申请日：2020-04-10

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N21/59 ,  G01N33/543 ,  G01N33/569 ,  G01N21/41 ,  G01N21/55 ,  G01N21/17

Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.

公开(公告)号：US11112347B2

公开(公告)日：2021-09-07

申请号：US16889430

申请日：2020-06-01

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N15/14 ,  G01N15/02 ,  G02B27/10 ,  G02B27/00 ,  G06E3/00 ,  G02B27/46 ,  B82Y10/00 ,  B82Y20/00

Abstract: Among other things, an imaging sensor includes a two-dimensional array of photosensitive elements and a surface to receive a sample within a near-field distance of the photosensitive elements. Electronics classify microbeads in the sample as belonging to different classes based on the effects of different absorption spectra of the different classes of microbeads on light received at the surface. In some examples, the number of different distinguishable classes of microbeads can be very large based on combinations of the effects on light received at the surface of the different absorption spectra together, spatial arrangements of colorants in the microbeads that impart the different absorption spectra, different sizes of microbeads, and different shapes of microbeads, among other things.

公开(公告)号：US10900999B2

公开(公告)日：2021-01-26

申请号：US16820904

申请日：2020-03-17

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01Q60/20 ,  G01N21/64 ,  G02B21/00 ,  G02B21/36 ,  H01L27/146

Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.

公开(公告)号：US20200309777A1

公开(公告)日：2020-10-01

申请号：US16845458

申请日：2020-04-10

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G01N33/569 ,  G01N21/41 ,  G01N21/59 ,  G01N21/55

Abstract: A method includes attaching two or more beads to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-bead complex including two or more beads and the unit of the chemical component; placing the sample on a surface of an image sensor; at the image sensor, receiving light originating at a light source, the received light including light reflected by, refracted by, or transmitted through the beads of the multi-bead complexes; at the image sensor, capturing one or more images of the sample from the received light; and identifying, in at least one of the images of the sample, separate multi-bead complexes, the identifying of the separate multi-bead complexes including associating the two or more beads of each of the multi-bead complexes based on proximity to one another.

公开(公告)号：US20200273900A1

公开(公告)日：2020-08-27

申请号：US16837640

申请日：2020-04-01

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Madhuranga Srinath Rankaduwa

IPC: H01L27/146 ,  G01N21/27 ,  G01N33/49 ,  G02B21/00

Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.

公开(公告)号：US20190341414A1

公开(公告)日：2019-11-07

申请号：US16514346

申请日：2019-07-17

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Madhuranga Srinath Rankaduwa

IPC: H01L27/146 ,  G01N33/49 ,  G01N21/27

Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.

公开(公告)号：US20190278075A1

公开(公告)日：2019-09-12

申请号：US16404633

申请日：2019-05-06

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G02B21/36 ,  G01N1/38 ,  G01N15/06 ,  G01N1/28 ,  G01N21/31 ,  G01N33/49 ,  B01L3/00

Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.

公开(公告)号：US20180231753A1

公开(公告)日：2018-08-16

申请号：US15943595

申请日：2018-04-02

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine

IPC: G02B21/00 ,  G02B21/36 ,  G01N33/80 ,  G01N15/14 ,  G06K9/00 ,  G01T1/02 ,  G01N11/00 ,  G03H1/00 ,  G01B9/02 ,  G03H1/04 ,  G01N15/00 ,  C12M1/34 ,  G01N15/10 ,  G06T7/00

CPC classification number: G02B21/0008 ,  C12M41/36 ,  G01B9/02041 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/80 ,  G01N2011/008 ,  G01N2015/0069 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2015/149 ,  G01T1/02 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/361 ,  G02B21/365 ,  G03H2001/005 ,  G03H2001/045 ,  G06K9/00127 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30242 ,  Y10S435/808

Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.