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公开(公告)号：US08314111B2
公开(公告)日：2012-11-20
申请号：US13106954
申请日：2011-05-13
Applicant: Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Quinghua Weng , James David Beard
Inventor： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Quinghua Weng , James David Beard
IPC: C07D487/04 , C07D403/04 , C07D403/14 , A61K31/519 , A61P19/02
CPC classification number: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US20120184533A1
公开(公告)日：2012-07-19
申请号：US13381856
申请日：2010-07-02
Applicant: Bijoy Panicker , Dong Sung Lim , David E. Smith
Inventor： Bijoy Panicker , Dong Sung Lim , David E. Smith
IPC: A61K31/55 , C07D403/04 , A61K31/4725 , A61K31/4184 , A61K31/4709 , A61P21/00 , A61P9/10 , A61P13/12 , A61P25/00 , A61P25/16 , A61P25/28 , A61P9/00 , A61P3/10 , A61P43/00 , A61P1/16 , A61P35/00 , A61P29/00 , A61P19/02 , C12N9/99 , C07D401/04
CPC classification number: C07D403/04 , C07D401/04
Abstract: Compounds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
Abstract translation: 提供了抑制聚ADP-核糖合成酶（PARP）的活性的化合物和药物组合物。 这些化合物可用于治疗各种疾病，病症和损伤如中风，心肌梗死，各种器官的缺血灌注损伤，创伤性脑损伤，动脉粥样硬化，炎性疾病和癌症。
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33.发明授权公开(公告)号：US08101613B2
公开(公告)日：2012-01-24
申请号：US12540047
申请日：2009-08-12
Applicant: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
Inventor： Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D487/00
CPC classification number: C07F5/025 , C07D471/04 , C07D487/04
Abstract: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
Abstract translation: 其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防 过度增生性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢神经系统的疾病和状况。
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公开(公告)号：US07943767B2
公开(公告)日：2011-05-17
申请号：US12622545
申请日：2009-11-20
Applicant: Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Quinghua Weng , James David Beard
Inventor： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Quinghua Weng , James David Beard
IPC: C07D487/04 , C07D403/04 , C07D401/14 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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35.发明申请公开(公告)号：US20090325928A1
公开(公告)日：2009-12-31
申请号：US12540047
申请日：2009-08-12
Applicant: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
Inventor： Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC: C07D471/04 , A61K31/495 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/04
CPC classification number: C07F5/025 , C07D471/04 , C07D487/04
Abstract: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
Abstract translation: 其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶，并且可用于治疗和/或预防 过度增生性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢神经系统的疾病和状况。
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Patent Agency Ranking
公开(公告)号：US20070112005A1
公开(公告)日：2007-05-17
申请号：US11599663
申请日：2006-11-15
Applicant: Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
Inventor： Xin Chen , Heather Coate , Andrew Crew , Han-Qing Dong , Ayako Honda , Mark Mulvihill , Paula Tavares , Jing Wang , Douglas Werner , Kristen Mulvihill , Kam Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James Beard
IPC: A61K31/498 , A61K31/53 , C07D487/12
CPC classification number: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US08865752B2
公开(公告)日：2014-10-21
申请号：US13935517
申请日：2013-07-04
Applicant: Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J. W. M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
Inventor： Bijoy Panicker , Dong Sung Lim , Rama K. Mishra , Lambertus J. W. M. Oehlen , James G. Tarrant , Xiaokang Zhu , Dawoon Jung
IPC: C07D417/12 , A61K31/428 , C07D417/06 , C07D417/04 , C07D417/14
CPC classification number: C07D417/06 , C07D417/04 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving fibrosis and proliferation, and where anti-fibrotic or anti-proliferative activity is beneficial.
Abstract translation: 本发明提供具有一般结构式（I）的化合物及其药学上可接受的衍生物，如本文中一般和本类和亚类所述，并且另外提供其药物组合物，以及用于治疗任何一种 涉及纤维化和增殖的病症或疾病，其中抗纤维化或抗增殖活性是有益的。
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公开(公告)号：US08796455B2
公开(公告)日：2014-08-05
申请号：US13767947
申请日：2013-02-15
Applicant: Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
Inventor： Xin Chen , Heather Coate , Andrew Philip Crew , Han-Qing Dong , Ayako Honda , Mark Joseph Mulvihill , Paula A. R. Tavares , Jing Wang , Douglas S. Werner , Kristen Michelle Mulvihill , Kam W. Siu , Bijoy Panicker , Apoorba Bharadwaj , Lee D. Arnold , Meizhong Jin , Brian Volk , Qinghua Weng , James David Beard
IPC: C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/5025 , A61P19/02 , A61P35/00
CPC classification number: C07D487/04 , A61K31/5025 , C07D253/07 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
Abstract: Compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of mTOR and useful in the treatment of cancer.
Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是mTOR的抑制剂，可用于治疗癌症。
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公开(公告)号：US20130303567A1
公开(公告)日：2013-11-14
申请号：US13941510
申请日：2013-07-14
Applicant: Bijoy Panicker , Dong Sung Lim , David E. Smith
Inventor： Bijoy Panicker , Dong Sung Lim , David E. Smith
IPC: C07D403/04 , C07D401/04
CPC classification number: C07D403/04 , C07D401/04
Abstract: Compounds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such compounds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
Abstract translation: 提供了抑制聚ADP-核糖合成酶（PARP）的活性的化合物和药物组合物。 这些化合物可用于治疗各种疾病，病症和损伤如中风，心肌梗死，各种器官的缺血灌注损伤，创伤性脑损伤，动脉粥样硬化，炎性疾病和癌症。
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公开(公告)号：US20120190716A1
公开(公告)日：2012-07-26
申请号：US13384759
申请日：2010-08-05
Applicant: Lambertus J.W.M. Oehlen , Bijoy Panicker
Inventor： Lambertus J.W.M. Oehlen , Bijoy Panicker
IPC: A61K31/4174 , A61P11/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P13/12 , A61P17/02 , A61P21/00 , A61P17/00 , A61P3/10 , A61K31/4196 , A61P1/16
CPC classification number: A61K31/4172 , A61K31/045 , A61K31/4164 , A61K31/4192 , A61K31/4196
Abstract: Methods are provided for treating or preventing chronic obstructive pulmonary diseases such as emphysema, and fibrotic diseases including heart, liver, kidney and vascular diseases, by administering to a subject a pharmaceutical composition comprising a compound that inhibits cytochrome P450RA or CYP26.
Abstract translation: 提供了通过向受试者施用包含抑制细胞色素P450RA或CYP26的化合物的药物组合物来治疗或预防慢性阻塞性肺疾病如肺气肿和包括心脏，肝脏，肾脏和血管疾病的纤维化疾病的方法。
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