公开(公告)号：US20220244260A1

公开(公告)日：2022-08-04

申请号：US17616246

申请日：2020-06-04

Applicant: Cambridge Enterprise Limited

Inventor： Walid T. KHALED ,  Sara PENSA ,  Karsten BACH

IPC: G01N33/574 ,  C12Q1/6886 ,  C12Q1/6881 ,  G01N33/50

Abstract: The present invention relates to a method of assessing the likelihood of a subject having breast cancer or a precancerous condition associated with breast cancer. The present invention also relates to a method of determining whether treatment of breast cancer in a subject is required, and to a chemotherapeutic agent for use in the treatment of a subject in need of said treatment.

公开(公告)号：US20220172905A1

公开(公告)日：2022-06-02

申请号：US17617671

申请日：2020-04-29

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Shahab AKHAVAN ,  Amin Taheri NAJAFABADI ,  Ilya GOYKHMAN ,  Luigi OCCHIPINTI ,  Andrea Carlo FERRARI

IPC: H01G9/20 ,  H01G9/00 ,  H01L27/30 ,  H01L51/42 ,  H01L51/50 ,  H01L51/52 ,  H01L51/00 ,  G01N27/12

Abstract: We disclose herein a hetero-structure comprising: a curved material; at least one layer of a first material rolled around the curved material; at least one intermediate layer rolled on the at least one layer of the first material; and at least one layer of a second material rolled around the at least one intermediate layer.

公开(公告)号：US11346814B2

公开(公告)日：2022-05-31

申请号：US16970603

申请日：2019-02-15

Applicant: Cambridge Enterprise Limited

Inventor： Andrew Flewitt ,  Ewelina Wajs ,  Girish Rughoobur

IPC: G01N29/036 ,  G01N29/02 ,  G01N29/24

Abstract: A resonator is disclosed for the detection of a mass analyte, such as a biological analyte. The resonator has: a piezoelectric layer formed of a piezoelectric material; a first resonator region and a second resonator region each occupying a corresponding region of the piezoelectric layer; electrodes disposed to apply a driving signal to the piezoelectric layer to generate bulk acoustic waves, the electrodes being common to the first resonator region and the second resonator region. In operation, the first resonator region has a first resonant frequency and the second resonator region has a second resonant frequency. The first resonator region and the second resonator region differ from each other in that the first resonator region is adapted to receive a mass analyte for the mass analyte selectively to attach to a surface of the first resonator region. In operation, attachment of the mass analyte selectively at the first resonator region causes a greater frequency shift in the first resonant frequency than in the second resonant frequency. Also disclosed is a corresponding method for the detection of a mass analyte.

公开(公告)号：US20220149946A1

公开(公告)日：2022-05-12

申请号：US17436575

申请日：2020-02-27

Applicant: Cambridge Enterprise Limited ,  Consorzio Nazionale Interuniversitario per le Telecomunicazioni (CNIT)

Inventor： Andrea C. FERRARI ,  Marco ROMAGNOLI ,  Michele MIDRIO ,  Alberto MONTANARO ,  Vito SORIANELLO

IPC: H04B10/40 ,  H04B10/64 ,  H04B1/38

Abstract: An RF transmitter comprising an optical source configured to generate a pair of optical lines separated by an RF carrier frequency. The transmitter may comprise a graphene photodetector having at least two electrical contacts; a transmit antenna coupled to a first of the electrical contacts; and an electrical data signal input connected to a second of the electrical contacts. The graphene photodetector is illuminated by the optical source; it may comprise a graphene photo-thermal effect (PTE) photodetector or a bolometric photodetector. A corresponding receiver is also described.

公开(公告)号：US20220140222A1

公开(公告)日：2022-05-05

申请号：US17230118

申请日：2021-04-14

Applicant: SUNAM CO., LTD. ,  CAMBRIDGE ENTERPRISE LIMITED

Inventor： Seung-Hyun MOON ,  Judith DRISCOLL ,  Ahmed KURUSUMOVIC ,  John FEIGHAN

IPC: H01L39/24

Abstract: Provided is a superconducting wire. The superconducting wire comprises a substrate, a superconducting film on the substrate and a pinning center in the superconducting film. The superconducting film includes Y1-xRExBCO and the pinning center has an additive of Ba2YNbO6.

公开(公告)号：US20220090054A1

公开(公告)日：2022-03-24

申请号：US17407074

申请日：2021-08-19

Applicant: Cambridge Enterprise Limited

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkeviciüte

IPC: C12N15/10 ,  C40B40/10 ,  C12N15/62 ,  C40B50/06 ,  C40B30/04

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

公开(公告)号：US11243211B2

公开(公告)日：2022-02-08

申请号：US16801009

申请日：2020-02-25

Applicant: Cambridge Enterprise Limited

Inventor： Alasdair J. Coles ,  Joanne L. Jones ,  Alastair Compston

IPC: G01N33/564 ,  G01N33/68 ,  C12Q1/6883 ,  C12Q1/6827 ,  C12N15/10 ,  A61P25/00 ,  A61P37/00

Abstract: The invention provides methods of diagnosing and treating multiple sclerosis (MS) patients, including methods of identifying and treating multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. The increased risk may be linked to certain single nucleotide polymorphism genotypes that are indicative of elevated IL-21 levels. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.

公开(公告)号：US20220026405A1

公开(公告)日：2022-01-27

申请号：US17277223

申请日：2019-09-19

Applicant: Fluidic Analytics Limited ,  Cambridge Enterprise Limited

Inventor： Tadas Kartanas ,  Tuomas Pertti Jonathan Knowles ,  Quentin Alexis Eric Peter ,  Kadi Liis Saar ,  Tom Scheidt ,  Thomas Mueller ,  Sean Devenish

IPC: G01N30/74 ,  G01N15/14

Abstract: A device and a method is provided for profiling particles such as proteins. The device comprises: a liquid chromatography column (16) in a mixture separation module (10); a fractionation device (22, 24) and a plurality of microfluidic analysis modules (26, 28) in a microfluidic network (14). The microfluidic analysis modules are configured to provide multi-dimensional analysis of the particles. Furthermore, a fluidic flow adaptor (20) allows for controlled flow between separator (16) and the microfluidic network to provide a continuous fluid flow.

公开(公告)号：US20220016627A1

公开(公告)日：2022-01-20

申请号：US17414856

申请日：2019-12-20

Applicant: Fluidic Analytics Limilted ,  Cambridge Enterprise Limited

Inventor： Tuomas Pertti Jonathan Knowles ,  Kadi Liis Saar ,  Quentin Alexia Eric Peter ,  Pavan Kumar Challa ,  Thomas Mueller

IPC: B01L3/00

Abstract: A flow apparatus for detecting a component on a surface is provided. The flow apparatus, comprising an inlet for receiving a solution of the components to be detected; a detection chamber in fluid connection with and downstream from the inlet, and in fluid connection with a downstream outlet, wherein the internal surface of the detection chamber comprises a plurality of detection zones and the detection zones are configured to adhere to the component to be detected such that the component is immobilised in the detection zones; a detector for detecting components immobilised on each of the detection zones; and a director for directing the flow of the solution of the components to each of the detection zones in sequence, wherein the director is provided by flow rates.

公开(公告)号：US20220013515A1

公开(公告)日：2022-01-13

申请号：US17385346

申请日：2021-07-26

Applicant: Cambridge Enterprise Limited ,  King Abdulaziz City for Science and Technology

Inventor： Akshay Rao ,  Bruno Ehrler ,  Richard Henry Friend ,  Maxim Tabachnyk

IPC: H01L25/16 ,  H01L51/44 ,  H01L51/50 ,  H01L31/055 ,  H01L31/028 ,  H01L31/0304 ,  H01L31/032 ,  H01L51/42

Abstract: A photovoltaic device and method utilizing a light harvesting device and a photovoltaic cell; wherein the light harvesting device includes an organic semiconductor photoactive layer capable of multiple exciton generation with a luminescent material dispersed therein; wherein the bandgap of the luminescent material is selected such that the triplet excitons, formed as a result from the multiple exciton generation in the organic semiconductor, can be transferred from the organic semiconductor into the luminescent material non-radiatively via Dexter Energy Transfer; a photovoltaic cell disposed in an emissive light path of the luminescent material and having a first photoactive layer, wherein the bandgap of the luminescent material matches or is higher than the bandgap of the first photoactive layer.