公开(公告)号：US20090074794A1

公开(公告)日：2009-03-19

申请号：US12270191

申请日：2008-11-13

Applicant: George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallen ,  David Shealy

Inventor： George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallen ,  David Shealy

IPC: A61K39/395 ,  A61P37/00

CPC classification number: C07K16/241 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  Y02A50/386 ,  Y02A50/412 ,  Y10S514/825 ,  Y10S514/826

Abstract: The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.

Abstract translation: 本发明涉及通过施用包含SEQ ID NO：7的重链可变区和SEQ ID NO：8的轻链可变区的抗TNF抗体来抑制具有类风湿性关节炎，银屑病关节炎或强直性脊柱炎的患者中的TNF， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段。

公开(公告)号：US07365154B2

公开(公告)日：2008-04-29

申请号：US10873848

申请日：2004-06-22

Applicant: David Shealy ,  Sam Wu ,  Yan Chen ,  Audrey Baker

Inventor： David Shealy ,  Sam Wu ,  Yan Chen ,  Audrey Baker

IPC: A61K38/04

CPC classification number: C07K7/06 ,  C07K14/70557

Abstract: The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.

Abstract translation: 本发明涉及在肿瘤学应用中具有治疗活性的α融合整联蛋白的拮抗剂，以及使用与已证实具有抗肿瘤活性的已知单克隆抗体竞争αV-整联蛋白结合的肽来选择此类拮抗剂的方法。 要求保护的肽表示存在于治疗性抗体选择性结合的配体上的构象表位或模拟表位。

公开(公告)号：US07166285B2

公开(公告)日：2007-01-23

申请号：US10975708

申请日：2004-10-28

Applicant: Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K39/395

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to an anti-IL-12 antibody, including isolated nucleic acids that encode an anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及抗IL-12抗体，包括编码抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。

公开(公告)号：US20060246073A1

公开(公告)日：2006-11-02

申请号：US11401337

申请日：2006-04-10

Applicant: David Knight ,  David Shealy

Inventor： David Knight ,  David Shealy

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K31/519 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/412 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

公开(公告)号：US20060246070A1

公开(公告)日：2006-11-02

申请号：US11241269

申请日：2005-09-30

Applicant: George Heavner ,  Jill Giles-Komar ,  David Knight ,  Bernard Scallon ,  David Shealy

Inventor： George Heavner ,  Jill Giles-Komar ,  David Knight ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  A61K38/17

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/565

Abstract: The present invention relates to methods for treating at least one renal cell carcinoma related condition or pathology, including therapeutic compositions, methods and devices, using TNF antagonists.

Abstract translation: 本发明涉及使用TNF拮抗剂治疗至少一种肾细胞癌相关病症或病理学的方法，包括治疗组合物，方法和装置。

公开(公告)号：US20050002937A1

公开(公告)日：2005-01-06

申请号：US10912994

申请日：2004-08-06

Applicant: Jill Giles-Komar ,  David Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

Inventor： Jill Giles-Komar ,  David Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A01H1/00 ,  A01K67/027 ,  A61K20060101 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P20060101 ,  A61P17/06 ,  A61P25/00 ,  A61P37/00 ,  A61P43/00 ,  C07K20060101 ,  C07K16/24 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/13 ,  C12P21/08 ,  G01N20060101 ,  C07H21/04 ,  C12N5/06

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to at least one novel anti-IL-12 antibodies, including isolated nucleic acids that encode at least one anti-IL-12 antibody, IL-12, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及至少一种新的抗IL-12抗体，包括编码至少一种抗IL-12抗体，IL-12，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 包括治疗组合物，方法和装置。

公开(公告)号：US09676848B2

公开(公告)日：2017-06-13

申请号：US15198678

申请日：2016-06-30

Applicant: Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

公开(公告)号：US20170029496A1

公开(公告)日：2017-02-02

申请号：US15198678

申请日：2016-06-30

Applicant: Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣。

公开(公告)号：US08329171B2

公开(公告)日：2012-12-11

申请号：US13299874

申请日：2011-11-18

Applicant: Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriatic arthritis.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣关节炎。

公开(公告)号：US08241899B2

公开(公告)日：2012-08-14

申请号：US12271120

申请日：2008-11-14

Applicant: George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

Inventor： George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

IPC: C12P21/08 ,  C07H21/04 ,  C12N15/63 ,  C12N15/28

CPC classification number: C07K16/241 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  Y02A50/386 ,  Y02A50/412 ,  Y10S514/825 ,  Y10S514/826

Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

Abstract translation: 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。