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公开(公告)号：US20090074794A1
公开(公告)日：2009-03-19
申请号：US12270191
申请日：2008-11-13
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.
摘要翻译： 本发明涉及通过施用包含SEQ ID NO：7的重链可变区和SEQ ID NO：8的轻链可变区的抗TNF抗体来抑制具有类风湿性关节炎，银屑病关节炎或强直性脊柱炎的患者中的TNF， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段。
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公开(公告)号：US08603778B2
公开(公告)日：2013-12-10
申请号：US13547557
申请日：2012-07-12
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译： 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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公开(公告)号：US07521206B2
公开(公告)日：2009-04-21
申请号：US11180219
申请日：2005-07-13
IPC分类号： C12N15/13 , C12N15/63 , C12N1/11 , C12N1/13 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/16
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的抗TNF抗体，包括编码至少一种抗TNF抗体，TNF，载体，宿主细胞，转基因动物或植物的分离核酸及其制备和使用方法，包括治疗 组合物，方法和装置。
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4.发明申请ANTI-TNF ANTIBODIES, COMPOSITIONS, METHODS AND USES FOR TREATMENT OF DEPRESSION AND RELATED CONDITIONS 审中-公开抗TNF抗体，组合物，治疗抑郁症及相关病症的方法和用途公开(公告)号：US20090081234A1
公开(公告)日：2009-03-26
申请号：US12274386
申请日：2008-11-20
IPC分类号： A61K39/395 , C12N5/00 , A61P25/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/567 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to novel anti-TNF antibodies for use in the treatment of depression, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及用于治疗抑郁症的新型抗TNF抗体，包括治疗组合物，方法和装置。
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公开(公告)号：US20120282170A1
公开(公告)日：2012-11-08
申请号：US13547557
申请日：2012-07-12
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/42 , C12N5/071 , G01N33/566 , A61K51/00 , C12N1/00 , G01N33/577 , A61P29/00 , A61P21/02 , A61P23/00 , A61P25/20 , A61P31/00 , A61P17/06 , A61P37/04 , A61P37/06 , A61P25/24 , A61P25/18 , A61P11/06 , C12N15/13
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译： 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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公开(公告)号：US07820169B2
公开(公告)日：2010-10-26
申请号：US12268955
申请日：2008-11-11
IPC分类号： A61K39/395 , A61K31/573 , A61K49/00 , C07K16/00
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.
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公开(公告)号：US08241899B2
公开(公告)日：2012-08-14
申请号：US12271120
申请日：2008-11-14
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译： 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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公开(公告)号：US07815909B2
公开(公告)日：2010-10-19
申请号：US12270191
申请日：2008-11-13
IPC分类号： A61K39/395 , A61K31/573 , C07K16/00 , A61K49/00
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable region of SEQ ID NO:8, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof.
摘要翻译： 本发明涉及通过施用包含SEQ ID NO：7的重链可变区和SEQ ID NO：8的轻链可变区的抗TNF抗体来抑制具有类风湿性关节炎，银屑病关节炎或强直性脊柱炎的患者中的TNF， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段。
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公开(公告)号：US07691378B2
公开(公告)日：2010-04-06
申请号：US10954900
申请日：2004-09-30
IPC分类号： A61K39/395 , A61K31/573 , A61K49/00 , C07K16/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody.
摘要翻译： 本发明涉及使用至少一种抗TNF抗体治疗癌或腺癌的方法。
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公开(公告)号：US20090252743A1
公开(公告)日：2009-10-08
申请号：US12268955
申请日：2008-11-11
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
摘要： The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS: 1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
摘要翻译： 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
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