公开(公告)号：US10752695B2

公开(公告)日：2020-08-25

申请号：US15197496

申请日：2016-06-29

Applicant: GENMAB A/S

Inventor： Jan Van De Winkel ,  Tom Vink ,  Janine Schuurman ,  Paul Parren ,  Rob Aalberse ,  Marijn Van Der Neut Kolfschoten

IPC: C07K16/00 ,  C12P21/08 ,  C07K16/28 ,  A61K51/10 ,  A61K47/68 ,  C07K16/16 ,  C07K16/18 ,  C07K1/00 ,  A61K39/00

Abstract: The present invention relates to novel stabilized IgG4 antibodies, to methods of producing such antibodies and to uses of such antibodies as a medicament. In a main aspect, the invention relates to a stabilized IgG4 antibody, comprising a heavy chain and a light chain, wherein said heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position (409), the Phe residue at position (405) or the Lys residue at position (370).

公开(公告)号：US10703818B2

公开(公告)日：2020-07-07

申请号：US15420824

申请日：2017-01-31

Applicant: GENMAB A/S

Inventor： Janine Schuurman ,  Catharina Emanuele Gerarda Havenith ,  Paul Parren ,  Jan G. J. Van De Winkel ,  Denise Leah Williams ,  Jørgen Petersen ,  Ole Baadsgaard

IPC: C07K16/20 ,  C07K16/30 ,  C07K16/40 ,  C07K16/28 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61N5/06 ,  C07K16/42 ,  C07K16/46 ,  G01N33/574 ,  G01N33/569 ,  A61K39/00

Abstract: Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：US10590206B2

公开(公告)日：2020-03-17

申请号：US14760157

申请日：2014-01-09

Applicant: GENMAB A/S

Inventor： Aran Frank Labrijn ,  Joyce Meesters ,  Joost J. Neijssen ,  Edward Norbert Van Den Brink ,  Janine Schuurman ,  Paul Parren

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/10 ,  C07K16/36 ,  C07K16/00 ,  C07K16/32 ,  C07K16/12 ,  A61K39/00

Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.

公开(公告)号：US20200062853A1

公开(公告)日：2020-02-27

申请号：US16316534

申请日：2017-07-14

Applicant: GENMAB A/S ,  BIONTECH AG

Inventor： Isil ALTINTAS ,  David SATIJN ,  Rik RADEMAKER ,  Paul PARREN ,  Friederike GIESEKE ,  Ugur SAHIN

IPC: C07K16/28 ,  G01N33/569 ,  A61K39/395

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.

公开(公告)号：US20190315877A1

公开(公告)日：2019-10-17

申请号：US16451714

申请日：2019-06-25

Applicant: GENMAB B.V.

Inventor： Marije OVERDIJK ,  Kristin STRUMANE ,  Rik RADEMAKER ,  Esther BREIJ ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  C12N15/62 ,  C07K16/46 ,  C07K16/30 ,  A61P35/00

Abstract: The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DR5 antigen. The invention relates in particular to DR5-specific antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DR5 signaling, apoptosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DR5. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.

公开(公告)号：US20190275149A1

公开(公告)日：2019-09-12

申请号：US16248402

申请日：2019-01-15

Applicant: GENMAB A/S

Inventor： Esther BREIJ ,  David SATIJN ,  Edward Norbert VAN DEN BRINK ,  Dennis VERZIJL ,  Rob N. DE JONG ,  Paul PARREN ,  Riemke VAN DIJKHUIZEN RADERSMA

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68

Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.

公开(公告)号：US10344050B2

公开(公告)日：2019-07-09

申请号：US14353962

申请日：2012-10-26

Applicant: GENMAB A/S

Inventor： Michael Gramer ,  Amitava Kundu ,  Ewald T. J. Van Den Bremer ,  Muriel Van Kampen ,  Patrick Priem ,  Aran Frank Labrijn ,  Joyce I. Meesters ,  Joost J. Neijssen ,  Janine Schuurman ,  Paul Parren ,  Patrick Van Berkel ,  Werner L. Vos ,  Arnout Gerritsen

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/46 ,  C07K1/113

Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.

公开(公告)号：US10201607B2

公开(公告)日：2019-02-12

申请号：US15938961

申请日：2018-03-28

Applicant: GENMAB A/S

Inventor： Esther Breij ,  David Satijn ,  Edward Norbert Van Den Brink ,  Dennis Verzijl ,  Rob N. De Jong ,  Paul Parren ,  Riemke Van Dijkhuizen Radersma

IPC: A61K39/00 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395

Abstract: The present invention relates to anti-AXL antibodies, immunoconjugates, compositions and method of treatment of cancer with such anti-AXL antibodies, immunoconjugates, or compositions.

公开(公告)号：US20190030178A1

公开(公告)日：2019-01-31

申请号：US15758520

申请日：2016-09-09

Applicant: GENMAB A/S

Inventor： Steen LISBY ,  Nancy Cherry WHITING

IPC: A61K47/68 ,  A61K38/07 ,  C07K16/36

Abstract: Anti-TF antibody drug conjugate and pharmaceutical compositions comprising the antibody drug-conjugate for use in the treatment of a solid cancer comprising administering to a subject a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an anti-TF antibody drug conjugate once a week for three consecutive weeks followed by a one week resting period without any administration of anti-TF ADC so that each cycle time is 28 days including the resting period.

公开(公告)号：US20190022243A1

公开(公告)日：2019-01-24

申请号：US16069395

申请日：2017-01-13

Applicant: GENMAB A/S

Inventor： Julia BOSHUIZEN ,  Esther BREIJ ,  Louise KOOPMAN ,  David SATIJN ,  Edward VAN DEN BRINK ,  Dennis VERZIJL ,  Rob DE JONG ,  Riemke VAN DIJKHUIZEN RADERSMA ,  Daniel PEEPER ,  Paul PARREN

IPC: A61K47/68 ,  C07K16/28 ,  A61P35/00

Abstract: Antibody-drug conjugates (ADCs) binding to human AXL for therapeutic use, particularly for treatment of melanoma in combination with one or more MAPK pathway inhibitors such as, e.g., a BRAF inhibitor and/or a MEK inhibitor.