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公开(公告)号：US20130274134A1
公开(公告)日：2013-10-17
申请号：US13881576
申请日：2011-10-26
IPC分类号： G01N33/50
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5044 , G01N33/5047
摘要： The present invention relates to an in vitro method for identifying agents capable of inducing sensitization of human skin and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 3A and/or 3B in MUTZ-3 cells exposed to a test agent.
摘要翻译： 本发明涉及用于鉴定能够诱导人皮肤和阵列致敏的试剂的体外方法以及用于这些方法的诊断试剂盒。 特别地，所述方法包括测量暴露于测试试剂的MUTZ-3细胞中表3A和/或3B中列出的生物标志物的表达。
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32.发明申请公开(公告)号：US20120099233A1
公开(公告)日：2012-04-26
申请号：US13280128
申请日：2011-10-24
摘要： A method and a device for supervising the sensitivity of a protection function in an electrical power system including a metering device for measuring values of a feature, said protection function being configured to initialize an action based on a test value and a threshold value for the feature, wherein said test value is either a measured value or derived from the said measured values, the device includes a computing unit configured to receive the test values and, repeatedly during the operation of the protection function, to calculate a mean value and a deviation of the test values, to determine the probability of a false action based on the calculated mean value, the threshold value and the calculated deviation, and to indicate that the sensitivity is too high when the probability of a false action exceeds a first limit value for the probability of a false action.
摘要翻译： 一种用于监视包括用于测量特征值的计量装置的电力系统中的保护功能的灵敏度的方法和装置，所述保护功能被配置为基于所述特征的测试值和阈值初始化动作 ，其中所述测试值是测量值或从所述测量值导出，所述设备包括被配置为接收所述测试值并且在所述保护功能的操作期间重复地计算平均值和偏差的计算单元 测试值，以基于计算的平均值，阈值和计算的偏差来确定错误动作的概率，并且当虚假动作的概率超过第一限制值时，表示灵敏度太高 误报的概率。
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公开(公告)号：US08065192B2
公开(公告)日：2011-11-22
申请号：US11901032
申请日：2007-09-14
申请人： Henrik Johansson , Jason Black
发明人： Henrik Johansson , Jason Black
IPC分类号： G06Q30/00
CPC分类号： G06Q30/06 , G06Q30/0605 , G06Q30/0621 , G06Q30/0641
摘要： Systems and methods for organizational purchasing are disclosed herein. More specifically, in certain embodiments a campaign corresponding to a product may be created and potential buyers informed of the campaign. These potential buyers may then themselves purchase the product in association with the campaign. In this manner not only are potential buyers informed that a product is being offered to one or more other buyers but the purchases of the individual buyers in association with the campaign may be aggregated to, for example, achieve a lower purchasing cost for each buyer relative to what the buyer would have paid if he had purchased only the quantity of product he desired.
摘要翻译： 本文公开了组织采购的系统和方法。 更具体地，在某些实施例中，可以创建与产品相对应的活动，并且潜在购买者通知该活动。 这些潜在买家可能会自己购买与该活动相关联的产品。 以这种方式，潜在购买者不仅知道向一个或多个其他买家提供产品，而且可以将与广告系列相关联的个体买家的购买合并为例如为每个买方相关的购买成本降低 如果他只购买了他想要的产品数量，买方将要支付的费用。
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34.发明申请METHOD FOR INTRODUCING COMMON AND/OR INDIVIDUAL SEQUENCE ELEMENTS IN A TARGET NUCLEIC ACID MOLECULE 审中-公开在目标核酸分子中引入通用和/或个体序列元件的方法公开(公告)号：US20100291636A1
公开(公告)日：2010-11-18
申请号：US12664177
申请日：2008-06-11
申请人： Henrik Johansson , Olof Ericsson
发明人： Henrik Johansson , Olof Ericsson
IPC分类号： C12P19/34
CPC分类号： C12N15/1065 , C12N15/10
摘要： The invention relates to a method for introducing common and/or individual sequence elements in a target nucleic acid molecule in a sample containing sample nucleic acid molecules, comprising the steps: i) denaturing the sample nucleic acid molecules, if the sample nucleic acid molecules are double-stranded, to obtain single stranded sample nucleic acid molecules; ii) bringing the sample nucleic acid molecules in contact with primary, secondary and tertiary probe nucleic acid molecules, wherein the 3′-end of the tertiary probe comprise a part complementary to the primary probe and the 5′-end of the tertiary probe comprise a part complementary to a 5′-part of the target nucleic acid molecule; the 3′-end of the secondary probe is complementary to a 3′-part of the target nucleic acid molecule and the 5′-end of the secondary probe is not complementary to the target nucleic acid molecule; wherein said primary, secondary and tertiary probes comprise said common and/or individual sequence elements; iii) ligating the 3′-end of the primary probe to the 5′-end of the target nucleic acid molecule; and iv) elongating the 3′-end of the secondary probe by means of a nucleic acid polymerase; or iv′) elongating the 3′-end of the target nucleic acid molecule.
摘要翻译： 本发明涉及在含有样本核酸分子的样品中引入目标核酸分子中的常见和/或单个序列元件的方法，其包括以下步骤：i）如果样品核酸分子为 双链，获得单链样品核酸分子; ii）使样品核酸分子与初级，次级和第三级探针核酸分子接触，其中第三级探针的3'-末端包含与主要探针互补的部分，并且第三探针的5'-末端包含 与靶核酸分子的5'-部分互补的部分; 第二探针的3'-末端与靶核酸分子的3'-部分互补，并且第二探针的5'-末端与靶核酸分子不互补; 其中所述初级，次级和第三级探针包括所述共同和/或单个序列元件; iii）将主要探针的3'-末端连接到靶核酸分子的5'-末端; 和iv）通过核酸聚合酶延伸第二探针的3'-末端; 或iv'）延伸靶核酸分子的3'末端。
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35.发明申请Method for automatically detecting factors that disturb analysis by a photometer 有权自动检测光度计干扰分析的因素的方法公开(公告)号：US20090009750A1
公开(公告)日：2009-01-08
申请号：US11665021
申请日：2004-10-11
申请人： Henrik Johansson
发明人： Henrik Johansson
IPC分类号： G01N33/487 , G01N21/59
CPC分类号： G01N21/314 , G01N33/72 , G01N2333/805
摘要： The invention concerns a method for detecting the amounts of substances that may disturb chemical analysis performed by an analyzer for clinical chemistry. The presence and concentration of hemoglobin, bilirubin and lipemia are detected by measuring the absorbance or reflectance on at least two, preferably six, different wavelengths over the measured spectrum. The measurements are performed at two wavelengths for each substance, preferably on the absorbance peaks of the specific substance and on the root of the specific peaks. Since the three substances mentioned above each have at least one peak in the spectrum, the measurement is done on three peaks and three root positions respectively when three substances have to be measured.
摘要翻译： 本发明涉及一种用于检测可能干扰由临床化学分析仪进行的化学分析的物质的量的方法。 血红蛋白，胆红素和脂血症的存在和浓度通过在测量的光谱上测量至少两个，优选六个不同波长的吸光度或反射率来检测。 对于每种物质，优选在特定物质的吸收峰上和特定峰的根上对两种波长进行测量。 由于上述三种物质在光谱中至少有一个峰，所以当必须测量三种物质时，分别测量三个峰和三个根位置。
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公开(公告)号：US20090007628A1
公开(公告)日：2009-01-08
申请号：US11665023
申请日：2004-10-11
IPC分类号： G01F25/00
CPC分类号： G01N35/1016 , B01L3/021 , B01L2200/146
摘要： A method for controlling the dispensation of a liquid volume sample when metering amounts of liquid by sucking into a tube, probe or tip a volume of a liquid to be displaced and ejecting the sample to a different vessel. According to the method the metering act is performed normally and the liquid to be metered is, displaced thereafter in a desired vessel. During the metering act and after a desired amount of liquid is sucked into the metering line, a supplementary suction step is performed wherefrom the success of the metering act can be deduced. The pressure function of the supplementary suction step is measured and this function is compared with a calibration function.
摘要翻译： 一种用于当通过吸入管中来测量液体量的液体量时，控制液体体积样品的分配的方法，探测或提取待移位的液体的体积并将样品排出到不同的容器。 根据该方法，计量作用是正常进行的，待计量的液体此后在期望的容器中移动。 在计量作业期间，并且在将所需量的液体吸入计量管线之后，执行辅助抽吸步骤，从而可以推断计量作用的成功。 测量辅助抽吸步骤的压力功能，并将此功能与校准功能进行比较。
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公开(公告)号：US07410966B2
公开(公告)日：2008-08-12
申请号：US10524204
申请日：2003-08-13
IPC分类号： C07D413/00 , C07D471/02 , C07D491/02 , C07D498/02 , A61K31/535 , A61K31/44 , A01N43/42
CPC分类号： C07D471/04 , A61K31/437
摘要： The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed
摘要翻译： 使用其中R 1，R 3，R 10，m和Ar的式（I）化合物如本说明书和 其药学上可接受的盐在制备用于治疗或预防其中抑制激酶Itk活性有益的疾病或病症的药物中的用途。 还公开了某些新的式（I）化合物及其制备方法，含有它们的组合物及其在治疗中的用途
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公开(公告)号：US20080135741A1
公开(公告)日：2008-06-12
申请号：US11984935
申请日：2007-11-26
IPC分类号： G01J3/50
CPC分类号： G01J3/12 , G01J2003/1213 , G01N21/255 , G01N21/31 , G01N21/47 , G01N2021/3133 , G01N2021/3174 , G01N2201/0696
摘要： The present invention relates to photometers wherein light signals on different wavelengths are directed to samples and a light scattered from or penetrated through the sample is measured with a photodetector. Method provides a required filtered light signal for a photometer (4). The method comprises providing a source of white light by a pulsed flash light source (7) and filtering the light signal for providing signals on different wavelengths by using multiple filters (6) arranged on a perimeter of a rotary filter disk (5). At least one filtered light signal is led to at least one photometer (4). The filter disk (5) Is rotated continuously for passing successive filters (6) over the path of light from the flash light source (7) to the photometer (4) and the flash light source (7) is triggered when a filter (6) providing the required wavelength of light is on the path of light from the flash light source (7) to the photometer (4).
摘要翻译： 本发明涉及光检测器，其中不同波长的光信号指向样品，并用光电检测器测量散射或穿透样品的光。 方法为光度计（4）提供所需的滤光光信号。 该方法包括通过脉冲闪光光源（7）提供白光源，并通过使用布置在旋转滤光片（5）的周边上的多个滤光片（6）来过滤光信号以提供不同波长的信号。 至少一个滤光的光信号被引导到至少一个光度计（4）。 过滤盘（5）连续旋转，以使连续的过滤器（6）穿过从闪光光源（7）到光度计（4）的光的路径，并且当过滤器（6） ）提供所需波长的光在从闪光光源（7）到光度计（4）的光的路径上。
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公开(公告)号：US20060292038A1
公开(公告)日：2006-12-28
申请号：US10545391
申请日：2004-01-15
申请人： Henrik Johansson , Juhani Makuhen
发明人： Henrik Johansson , Juhani Makuhen
CPC分类号： G01N35/025
摘要： An automated sample analyzer (10) has a sample store (20) and a sample dispenser (90) which is controlled by a controller (170). Samples of a substance to be analyzed are dispensed into a cuvette (60), along with a reagent from a reagent storage compartment (40), after which incubation occurs in an incubator (70). The incubated analyte is then passed to a sample analysis module (140). This has a photometric analysis arrangement (150) and a twin photon excitation (TPX) analysis arrangement (160). The incubated analyte is analyzed using one or other of the arrangements (150, 160). By parallel processing of samples in the analysers (150), (160), a rapid throughput of samples is possible but with the possibility of both photometric and TPX analysis. The cuvette (60) is of a tapered design which is particularly suitable for samples to be analysed by either arrangement (150, 160).
摘要翻译： 自动化样品分析仪（10）具有由控制器（170）控制的样品储存器（20）和样品分配器（90）。 要分析的物质的样品与来自试剂储存室（40）的试剂一起分配到比色皿（60）中，之后在培养箱（70）中进行孵育。 然后将温育的分析物传递到样品分析模块（140）。 这具有光度分析装置（150）和双光子激发（TPX）分析装置（160）。 使用一个或另一个布置（150,160）分析孵育的分析物。 通过在分析仪（150），（160）中并行处理样品，样品的快速通量是可能的，但具有光度测定和TPX分析的可能性。 试管（60）具有锥形设计，特别适用于通过任一装置（150,160）进行分析的样品。
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公开(公告)号：US20050261333A1
公开(公告)日：2005-11-24
申请号：US10524204
申请日：2003-08-13
IPC分类号： A61K31/437 , A61P11/06 , A61P37/08 , C07D471/04 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , A61K31/437
摘要： The use of compounds of formula (I) wherein R1, R3, R10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed.
摘要翻译： 使用其中R 1，R 3，R 10，m和Ar的式（I）化合物如本说明书和 其药学上可接受的盐在制备用于治疗或预防其中抑制激酶Itk活性有益的疾病或病症的药物中的用途。 还公开了某些新的式（I）化合物及其制备方法，含有它们的组合物及其在治疗中的用途。
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