公开(公告)号：US20120307178A1

公开(公告)日：2012-12-06

申请号：US13244284

申请日：2011-09-24

Applicant: Hui-Chuan Cheng ,  Shin-Tson Wu ,  Jin Yan ,  Young-Ran Chuang ,  Ching-Huan Lin

Inventor： Hui-Chuan Cheng ,  Shin-Tson Wu ,  Jin Yan ,  Young-Ran Chuang ,  Ching-Huan Lin

IPC: G02F1/13357

CPC classification number: G02F1/133524 ,  G02B6/0053 ,  G02F1/1334 ,  G02F1/1336 ,  G02F1/1393 ,  G02F2001/133562 ,  G02F2001/13793

Abstract: A display device includes a display module, a light source module and a guiding optical film. The display module includes a first substrate, a second substrate and a display medium. The light source module generates directional light. The display module has a vertical electric field. The display medium is optically isotropic, and the display medium is optically anisotropic when driven by the vertical electric field. The directional light is not perpendicular to the first substrate when the directional light enters the display nodule. The directional light is not perpendicular to the second substrate when the directional light exits the display module. The guiding optical film is disposed on the second substrate and has a light incident surface and a light emitting surface. After the directional light exits the guiding optical film, emitting light is formed, and the emitting light and the light emitting surface has an included angle there between.

Abstract translation: 显示装置包括显示模块，光源模块和引导光学薄膜。 显示模块包括第一基板，第二基板和显示介质。 光源模块产生定向光。 显示模块具有垂直电场。 显示介质是光学各向同性的，并且当由垂直电场驱动时，显示介质是光学各向异性的。 当定向光进入显示结节时，定向光不垂直于第一基底。 当定向光离开显示模块时，定向光不垂直于第二基板。 引导光学膜设置在第二基板上，具有光入射面和发光面。 在定向光离开引导光学膜之后，形成发光，发光和发光面之间具有夹角。

公开(公告)号：US20120062146A1

公开(公告)日：2012-03-15

申请号：US13051453

申请日：2011-03-18

Applicant: Chung-Tsai Huang ,  Shang-Jin Yan

Inventor： Chung-Tsai Huang ,  Shang-Jin Yan

IPC: H05B37/02

CPC classification number: H05B33/0887 ,  H05B33/0809 ,  H05B33/083

Abstract: A lamp driving device is provided for driving plural lamps. The lamp driving device includes a power conversion circuit and plural lamp connectors. The power conversion circuit is capable of converting an input voltage into a first DC voltage, and outputting a first current having a constant current value. The plural lamp connectors are serially connected with each other, and have respective positive terminals and respective negative terminals connected with corresponding lamps, thereby outputting respective output voltages and respective output currents to corresponding lamps. The first DC voltage is subject to voltage-division to obtain the output voltages, and the magnitudes of the output voltages from the lamps are substantially identical.

Abstract translation: 提供一种用于驱动多个灯的灯驱动装置。 灯驱动装置包括电源转换电路和多个灯连接器。 电力转换电路能够将输入电压转换为第一直流电压，并输出具有恒定电流值的第一电流。 多个灯连接器彼此串联连接，并且各自的正极端子和各个负极端子与相应的灯连接，从而将相应的输出电压和相应的输出电流输出到相应的灯。 第一直流电压进行分压以获得输出电压，并且来自灯的输出电压的大小基本相同。

公开(公告)号：US20100001661A1

公开(公告)日：2010-01-07

申请号：US12489984

申请日：2009-06-23

Applicant: Chung-Tsai Huang ,  Shang-Jin Yan ,  Po-Yi Lee

Inventor： Chung-Tsai Huang ,  Shang-Jin Yan ,  Po-Yi Lee

IPC: H05B37/02

CPC classification number: H05B33/0818 ,  Y02B20/347

Abstract: A LED current-controlling circuit includes a first magnetic amplifier, a first current detecting circuit, a first magnetic amplifier controller and a first diode. The first magnetic amplifier is connected to an input terminal of the LED current-controlling circuit and the first LED string. The first current detecting circuit is connected to the first LED string in series for detecting the first current flowing through the first LED string. The first magnetic amplifier controller is used for controlling on/off statuses of the first magnetic amplifier. The first diode is connected to an output terminal of the first magnetic amplifier, the first LED string and the first magnetic amplifier controller. The first magnetic amplifier controller controls on/off statuses of the first magnetic amplifier according to the magnitude of the first current, thereby maintaining the first current at a specified DC current level.

Abstract translation: LED电流控制电路包括第一磁放大器，第一电流检测电路，第一磁放大器控制器和第一二极管。 第一磁放大器连接到LED电流控制电路和第一LED串的输入端。 第一电流检测电路串联连接到第一LED串，用于检测流过第一LED串的第一电流。 第一磁放大器控制器用于控制第一磁放大器的开/关状态。 第一二极管连接到第一磁放大器的输出端，第一LED串和第一磁放大器控制器。 第一磁放大器控制器根据第一电流的大小控制第一磁放大器的开/关状态，从而将第一电流保持在指定的直流电流水平。

公开(公告)号：US20090315480A1

公开(公告)日：2009-12-24

申请号：US12236237

申请日：2008-09-23

Applicant: Shang-Jin Yan ,  Chung-Tsai Huang ,  Po-Yi Lee

Inventor： Shang-Jin Yan ,  Chung-Tsai Huang ,  Po-Yi Lee

IPC: H05B41/36

CPC classification number: H05B33/0815 ,  H05B33/0845

Abstract: A brightness-adjustable LED driving circuit includes a rectifying and filtering circuit, a power factor correction power conversion circuit, and a detecting and controlling circuit. The rectifying and filtering circuit is used for filtering and rectifying a brightness adjusting voltage into a first DC voltage. The power factor correction power conversion circuit is electrically connected to the rectifying and filtering circuit and at least one LED string for generating an output current required for powering the at least one LED string. The detecting and controlling circuit detects phase data of the brightness adjusting voltage and the output current generated by the power factor correction power conversion circuit. The detecting and controlling circuit generates a control signal to the power factor correction controller according to the phase data of the brightness adjusting voltage, so that the magnitude of the output current is changed according to the phase data of the brightness adjusting voltage.

Abstract translation: 亮度可调的LED驱动电路包括整流滤波电路，功率因数校正功率转换电路和检测和控制电路。 整流滤波电路用于将亮度调整电压滤波和整流为第一直流电压。 功率因数校正功率转换电路电连接到整流和滤波电路以及至少一个LED串，用于产生为至少一个LED串供电所需的输出电流。 检测和控制电路检测亮度调节电压和由功率因数校正功率转换电路产生的输出电流的相位数据。 检测和控制电路根据亮度调节电压的相位数据向功率因数校正控制器产生控制信号，使得输出电流的大小根据亮度调节电压的相位数据而改变。

公开(公告)号：US07449561B1

公开(公告)日：2008-11-11

申请号：US10371222

申请日：2003-02-24

Applicant: Steve S. Sommer ,  Jinong Feng ,  Carolyn Buzin ,  Jin Yan ,  Jeffrey Towbin

Inventor： Steve S. Sommer ,  Jinong Feng ,  Carolyn Buzin ,  Jin Yan ,  Jeffrey Towbin

IPC: C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to detect a human sporadic DCM predisposing gene, specifically the dystrophin gene, some mutant alleles of which cause susceptibility to sporadic DCM. More specifically, the invention relates to germline mutations in the dystrophin gene and their use in the diagnosis of predisposition to sporadic DCM. The invention also relates to the prophylaxis and/or therapy of sporadic DCM associated with a mutation in the dystrophin gene. The invention further relates to the screening of drugs for sporadic DCM therapy. Finally, the invention relates to the screening of the dystrophin gene for mutations/alterations, which are useful for diagnosing the predisposition to sporadic DCM.

Abstract translation: 本发明一般涉及人类遗传学领域。 具体地说，本发明涉及用于检测人类散发性DCM倾向性基因，特别是肌营养不良蛋白基因的一些突变等位基因导致对散发性DCM的易感性的方法和材料。 更具体地，本发明涉及肌营养不良蛋白基因中的种系突变及其在诊断散发性DCM的易感性中的用途。 本发明还涉及与肌营养不良蛋白基因突变相关的散发性DCM的预防和/或治疗。 本发明还涉及用于零星DCM治疗的药物的筛选。 最后，本发明涉及用于突变/改变的肌营养不良蛋白基因的筛选，其可用于诊断散发性DCM的易感性。

公开(公告)号：US6096881A

公开(公告)日：2000-08-01

申请号：US865666

申请日：1997-05-30

Applicant: Yongxin Han ,  Jimmy Tang ,  Zhoada Zhang ,  Jin-Yan Tang

Inventor： Yongxin Han ,  Jimmy Tang ,  Zhoada Zhang ,  Jin-Yan Tang

IPC: C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D285/16 ,  C07H21/00 ,  C07D285/01 ,  C07H21/02

CPC classification number: C07D285/16 ,  C07H21/00

Abstract: In our research, two commercially available compounds, 3-amino-1,2,4-dithiazole-5-thione (1) and xanthane hydride (2), and their derivatives 3-6 are found to be potential sulfur-transfer reagents. The efficiency and optimization of these new sulfur-transfer reagents were investigated by solid-phase syntheses of dinudeotide and oligonucleotide phosphorothioates. The results show that both compounds 1 and 2 are highly efficient sulfurizing reagents, and better than 99% sulfur transfer efficiency can be achieved at each step. In contrast to Beaucage reagent, these novel sulfur-transfer reagents are very stable in various solvents, and are available in bulk quantities at low cost. Due to these advantages, compounds 1 and 2 can be considered alternatives to Beaucage reagent, especially in large-scale preparation of oligonucleotide phosphorothioates. Furthermore, compounds 1 and 2 were modified to enhance their solubility in acetonitrile. Three types of structure, as described as Formulae I, II, and III, are considered as potential efficient sulfur-transfer reagents based on our results.

Abstract translation: 在我们的研究中，发现两种市售化合物，3-氨基-1,2,4-二噻唑-5-硫酮（1）和氢化蒽（2）及其衍生物3-6是潜在的硫转移试剂。 通过二肽和寡核苷酸硫代磷酸酯的固相合成研究了这些新型硫转移试剂的效率和优化。 结果表明，化合物1和化合物2均为高效硫化试剂，每步可达99％以上的硫转移效率。 与Beaucage试剂相反，这些新型硫转移试剂在各种溶剂中非常稳定，并且可以以低成本批量获得。 由于这些优点，化合物1和2可以被认为是拜耳试剂的替代物，特别是在大规模制备寡核苷酸硫代磷酸酯时。 此外，化合物1和2被修饰以增强其在乙腈中的溶解度。 根据我们的结果，三种类型的结构，如式I，II和III所述被认为是潜在的有效的硫转移试剂。

公开(公告)号：US6087491A

公开(公告)日：2000-07-11

申请号：US827561

申请日：1997-05-02

Applicant: Jin-Yan Tang ,  Nandkumar Bongle ,  Jose Gonzalez ,  Warren E. Schwartz

Inventor： Jin-Yan Tang ,  Nandkumar Bongle ,  Jose Gonzalez ,  Warren E. Schwartz

IPC: C07H21/00

CPC classification number: C07H21/00

Abstract: The present invention comprises an improved method of synthesizing oligonucleotides. The method comprises employing dinucleotides (or "dimer blocks") as the basic synthetic unit building block. The method results in extremely high purity oligonucleotides in which the N-1 content is very low, generally less than 1-2% of the full length, N, oligonucleotide. We have found that synthesis using dinucleotide phosphorothioates results in oligonucleotides having very little phosphodiester content. Furthermore, we have found that the amount of dimer required in each coupling step can be less than about 6 and is preferably about 2 equivalents. Synthesis of oligonucleotides according to the dimer block approach described herein can also be conducted without the capping step that has heretofore been deemed necessary after each coupling.

Abstract translation: 本发明包括一种合成寡核苷酸的改进方法。 该方法包括使用二核苷酸（或“二聚体嵌段”）作为基本合成单元结构单元。 该方法产生非常高纯度的寡核苷酸，其中N-1含量非常低，通常小于全长N，寡核苷酸的1-2％。 我们已经发现，使用二核苷酸硫代磷酸酯的合成导致寡核苷酸具有非常少的磷酸二酯含量。 此外，我们已经发现，每个偶联步骤中所需的二聚体的量可以小于约6，优选约为2当量。 根据本文所述的二聚体嵌段方法的寡核苷酸的合成也可以在每次偶联之前已经被认为是必要的封端步骤的情况下进行。

公开(公告)号：US5652103A

公开(公告)日：1997-07-29

申请号：US412913

申请日：1995-03-29

Applicant: Sudhir Agrawal ,  Jin-Yan Tang

Inventor： Sudhir Agrawal ,  Jin-Yan Tang

IPC: C12N15/09 ,  C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6855 ,  C12Q1/6869 ,  Y10T436/143333

Abstract: The invention relates to synthetic oligonucleotides and more particularly to the determination of nucleotide sequences of synthetic oligonucleotides having non-phosphodiester internucleotide linkages. The invention provides a method for sequencing such modified synthetic oligonucleotides.

Abstract translation: 本发明涉及合成的寡核苷酸，更具体地涉及确定具有非磷酸二酯核苷酸间键的合成寡核苷酸的核苷酸序列。 本发明提供了对这种修饰的合成寡核苷酸进行测序的方法。

公开(公告)号：US5554744A

公开(公告)日：1996-09-10

申请号：US311156

申请日：1994-09-23

Applicant: Nandkumar Bhongle ,  Jin-Yan Tang

Inventor： Nandkumar Bhongle ,  Jin-Yan Tang

IPC: C07H21/00

CPC classification number: C07H21/00

Abstract: New methods of loading solid supports for oligonucleotide synthesis are presented. The new methods comprise coupling a succinylated nucleoside to a solid support using diisopropylcarbodiimide (DIC) as an activator and N-hydroxybenzotriazole (HOBT) as an acid catalyst. DIC is substantially cheaper than the currently used activating agent, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (DEC). Furthermore, in the preferred embodiment, when it is used in combination with HOBT, coupling is more efficient, requiring less nucleoside to achieve the same loading densities as in the prior art. The loading process is faster than prior art methods and the overall cost savings of about 43% are realized.

Abstract translation: 提出了加载寡核苷酸合成固体载体的新方法。 新方法包括使用二异丙基碳二亚胺（DIC）作为活化剂和作为酸催化剂的N-羟基苯并三唑（HOBT）将琥珀酰化的核苷偶联到固体支持物上。 DIC比目前使用的活化剂，1-（3-二甲基氨基丙基）-3-乙基碳二亚胺（DEC）便宜得多。 此外，在优选实施方案中，当与HOBT组合使用时，耦合更有效，需要更少的核苷以实现与现有技术相同的装载密度。 加载过程比现有技术方法更快，并且实现了约43％的总体成本节约。

公开(公告)号：US5510475A

公开(公告)日：1996-04-23

申请号：US320835

申请日：1994-10-07

Applicant: Sudhir Agrawal ,  Jin-Yan Tang

Inventor： Sudhir Agrawal ,  Jin-Yan Tang

IPC: C07H21/04 ,  C07F9/141 ,  C07H21/00 ,  C12N15/09 ,  C12Q1/68

CPC classification number: C07H21/00 ,  C07F9/1411

Abstract: Oligonucleotides containing multiple free amino groups attached directly to the phosphorus atoms of the phosphodiester linkages having the structure shown below. ##STR1## wherein D=a ribonucleoside or deoxyribonucleotide;p=a 5' to 3'-phosphodiester or phosphoramidate linkage;n=1 to 20;a=1 to 20;b=1 to 20;c=1=20;z=0 to 20;t=1 to 100; andwhereinfor each repeating unit, "a" represents the same number or a different number than that number represented by "a" in every other repeating unit; and for each repeating unit "b" represents the same number or a different number than represented by "b" in every other repeating unit.Multiple reporter molecules can be incorporated into the oligonucleotide via the free amino groups allowing for increased probe sensitivity.

Abstract translation: 含有多个游离氨基的寡核苷酸，其直接连接到具有下面所示结构的磷酸二酯键的磷原子上。 其中D =核糖核苷或脱氧核糖核苷酸; p = 5'至3'-磷酸二酯或氨基磷酸酯键; n = 1〜20; a = 1〜20; b = 1〜20; c = 1 = 20; z = 0〜20; t = 1〜100; 并且其中对于每个重复单元，“a”表示与每隔一个重复单元中由“a”表示的数字相同的数字或不同的数字; 并且对于每个重复单元“b”表示与每隔一个重复单元中的“b”相同的数字或不同的数字。 多个报道分子可以通过游离氨基引入寡核苷酸，从而增加探针灵敏度。