公开(公告)号：US20060051844A1

公开(公告)日：2006-03-09

申请号：US10935005

申请日：2004-09-03

Applicant: George Heavner ,  David Knight ,  John Ghrayeb ,  Bernard Scallon ,  Thomas Nesspor ,  Chichi Huang

Inventor： George Heavner ,  David Knight ,  John Ghrayeb ,  Bernard Scallon ,  Thomas Nesspor ,  Chichi Huang

IPC: C07H21/04 ,  C12P21/04 ,  C07K14/505

CPC classification number: C07K14/505 ,  Y10S435/972

Abstract: The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及至少一种新的人EPO模拟铰链核心模拟体或特定部分或变体，包括编码至少一个EPO模拟铰链核心模拟体或特定部分或变体的分离的核酸，EPO模拟铰链核心模拟体或特定部分或 变体，载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。

公开(公告)号：US20060018907A1

公开(公告)日：2006-01-26

申请号：US11182033

申请日：2005-07-14

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  Y02A50/412

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症（包括强直性脊柱炎）的体内诊断和治疗，以及编码 提供了鼠和嵌合抗体，免疫测定和免疫治疗方法中产生抗体的方法，抗TNF抗体或其片段，区域或衍生物的使用方法。

公开(公告)号：US20050249735A1

公开(公告)日：2005-11-10

申请号：US11010954

申请日：2004-12-13

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  C07K16/30

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/241 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/92 ,  C07K2319/00 ,  Y02A50/412

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症（包括强直性脊柱炎）的体内诊断和治疗，以及编码 提供了鼠和嵌合抗体，免疫测定和免疫治疗方法中产生抗体的方法，抗TNF抗体或其片段，区域或衍生物的使用方法。

公开(公告)号：US06790444B2

公开(公告)日：2004-09-14

申请号：US09756301

申请日：2001-01-08

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39395

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-&agr; (TNF&agr;) and are useful in vivo diagnosis and therapy of a number of TNF&agr;-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

公开(公告)号：US5698195A

公开(公告)日：1997-12-16

申请号：US324799

申请日：1994-10-18

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K38/00 ,  C07K16/24 ,  A61K39/395 ,  C07K14/495 ,  C12N15/13

CPC classification number: C07K16/241 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00 ,  Y10S514/825

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo for diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and conditions, including rheumatoid arthritis as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFα）特异性的片段和区域，并且可用于诊断和治疗许多TNFα介导的病理学和病症，包括类风湿性关节炎以及 提供了编码鼠和嵌合抗体的多核苷酸，制备抗体的方法，抗TNF抗体的使用方法或其片段，区域或衍生物，在免疫测定和免疫治疗方法中。

公开(公告)号：US07416729B2

公开(公告)日：2008-08-26

申请号：US11820214

申请日：2007-06-18

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07374761B2

公开(公告)日：2008-05-20

申请号：US11891036

申请日：2007-08-08

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/24

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07335358B2

公开(公告)日：2008-02-26

申请号：US11633650

申请日：2006-12-04

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/24

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20080025976A1

公开(公告)日：2008-01-31

申请号：US11713534

申请日：2007-03-02

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

IPC: A61K39/395 ,  A61P19/00 ,  C12P21/08

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/241 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/92 ,  C07K2319/00 ,  Y02A50/412

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症（包括强直性脊柱炎）的体内诊断和治疗，以及编码 提供了鼠和嵌合抗体，免疫测定和免疫治疗方法中产生抗体的方法，抗TNF抗体或其片段，区域或衍生物的使用方法。

公开(公告)号：US20080003228A1

公开(公告)日：2008-01-03

申请号：US11820214

申请日：2007-06-18

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  A61P37/00

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。