公开(公告)号：US20110092540A1

公开(公告)日：2011-04-21

申请号：US12991655

申请日：2009-05-08

Applicant: Josep Mas Prio ,  Antoni Torrens Jover

Inventor： Josep Mas Prio ,  Antoni Torrens Jover

IPC: A61K31/4725 ,  C07D401/14 ,  C07D513/04 ,  A61K31/429 ,  A61P3/04 ,  A61P3/10 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07D513/04 ,  C07D519/00

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT6; receptor, and more particularly to some N-phenyl-2,3-dihydroimidazol[2,1-b]thiazole-5-sulfonamide derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT6 is involved.

Abstract translation: 本发明涉及对5-HT6具有药理活性的化合物; 更具体地涉及一些N-苯基-2,3-二氢咪唑并[2,1-b]噻唑-5-磺酰胺衍生物，制备这些化合物的方法，包括它们的药物组合物及其用于 治疗和/或预防其中涉及5-HT6的疾病。

公开(公告)号：US20090264458A1

公开(公告)日：2009-10-22

申请号：US12471128

申请日：2009-05-22

Applicant: Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

Inventor： Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

IPC: A61K31/473 ,  A61P25/00

CPC classification number: C07D221/16 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  Y10S514/914 ,  Y10S514/923

Abstract: The invention relates to compounds having pharmacological activity towards the 5-receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-受体具有药理活性的化合物，更具体地涉及一些2,2a，4,5-四氢-1H-3-氮杂 - 苊烯取代的磺酰胺化合物，制备这些化合物的方法， 包含它们的组合物，以及它们用于治疗和/或预防其中涉及5-HT的疾病如CNS障碍的用途。

公开(公告)号：US20090036480A1

公开(公告)日：2009-02-05

申请号：US11813069

申请日：2005-12-27

Applicant: Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

Inventor： Antoni Torrens Jover ,  Susana Yenes Minguez ,  Josep Mas Prio ,  Luz Romero Alonso ,  Alberto Dordal Zueras ,  Helmut Henrich Buschmann

IPC: A61K31/439 ,  C07D221/06 ,  A61P25/00 ,  A61P9/00 ,  A61P1/00

CPC classification number: C07D221/16 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  Y10S514/914 ,  Y10S514/923

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地涉及一些2,2a，4,5-四氢-1H-3-氮杂 - 苊烯取代的磺酰胺化合物，用于制备这些化合物的方法， 包含它们的药物组合物，以及它们用于治疗和/或预防其中涉及5-HT的疾病如CNS障碍的用途。

公开(公告)号：US20070105853A1

公开(公告)日：2007-05-10

申请号：US10566399

申请日：2004-07-29

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Fisas Escasany ,  Helmut-Heinrich Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Maria Fisas Escasany ,  Helmut-Heinrich Buschmann

IPC: A61K31/5377 ,  A61K31/454 ,  C07D413/14 ,  C07D403/02

CPC classification number: C04B35/632 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12

Abstract: The present invention relates to 1,4-disubstituted piperidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals. The substituents are as defined in the present claim 1.

Abstract translation: 本发明涉及通式（I）的1,4-二取代哌啶化合物，其制备方法，包含这些化合物的药物及其用于制备治疗人或动物的药物的用途。 取代基如权利要求1中所定义。

公开(公告)号：US07211584B2

公开(公告)日：2007-05-01

申请号：US10920671

申请日：2004-08-18

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut H. Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut H. Buschmann

IPC: C07D217/00 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D217/04

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US20070059364A1

公开(公告)日：2007-03-15

申请号：US10566100

申请日：2004-07-29

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Xavier Codony Soler ,  Ramon Merce Vidal ,  Jose-Aurello Castrillo Perez ,  Jordi Frigola Constansa ,  Helmut-Heinrich Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Alberto Dordal Zueras ,  Xavier Codony Soler ,  Ramon Merce Vidal ,  Jose-Aurello Castrillo Perez ,  Jordi Frigola Constansa ,  Helmut-Heinrich Buschmann

IPC: A61K31/538 ,  A61K31/404 ,  A61K9/22

CPC classification number: A61K31/404 ,  A61K31/4045 ,  A61K31/536 ,  A61K2300/00

Abstract: The present invention relates to an active substance combination comprising at least one compound with neuropeptide Y-receptor affinity and at least one compound with 5-HT6 receptor affinity, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

Abstract translation: 本发明涉及包含至少一种具有神经肽Y受体亲和力的化合物和至少一种具有5-HT 6受体亲和力的化合物的活性物质组合物，包含所述活性物质组合的药物，以及所述活性物质组合物用于 制造药物。

公开(公告)号：US20060040977A1

公开(公告)日：2006-02-23

申请号：US10920671

申请日：2004-08-18

Applicant: Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

Inventor： Antoni Torrens Jover ,  Josep Mas Prio ,  Susana Yenes Minguez ,  Monica Garcia Lopez ,  Alberto Dordal Zueras ,  Luz Romero Alonso ,  Helmut Buschmann

IPC: C07D217/12 ,  A61K31/47

CPC classification number: C07D401/12 ,  C07D217/04

Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

Abstract translation: 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。

公开(公告)号：US06355659B1

公开(公告)日：2002-03-12

申请号：US09492640

申请日：2000-01-27

Applicant: Ramon Merce-Vidal ,  Jordi Frigola-Constansa ,  Blas Andaluz-Mataró ,  Josep Mas-Prió

Inventor： Ramon Merce-Vidal ,  Jordi Frigola-Constansa ,  Blas Andaluz-Mataró ,  Josep Mas-Prió

IPC: A61K314439

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/06

Abstract: Antipsychotic compound 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-[4-(1H-1,2,4-triazol-1-yl) butyl]pyridine, or one of its physiologically acceptable salts, pharmaceutical compositions containing those compounds and a method of treating a disease selected from psychosis and dementias in which a deficit of cognition predominates comprising administering to a patient in need of such treatment a therapeutically effective amount of the antipsychotic compound.

Abstract translation: 抗精神病药化合物4-（4-氯苯基）-1,2,3,6-四氢-1- [4-（1H-1,2,4-三唑-1-基）丁基]吡啶或其生理上可接受的 盐，含有这些化合物的药物组合物和治疗选自认知缺陷占主导地位的精神病和痴呆症的疾病的方法，包括向需要这种治疗的患者施用治疗有效量的抗精神病化合物。