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公开(公告)号：US08188115B2
公开(公告)日：2012-05-29
申请号：US11658924
申请日：2005-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Mónica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Henrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Mónica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Henrich Buschmann
IPC分类号： C07D217/18 , A61K31/47
CPC分类号： C07D513/04 , C07D217/04 , C07D401/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US20090163542A1
公开(公告)日：2009-06-25
申请号：US11658924
申请日：2005-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Henrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Henrich Buschmann
IPC分类号： A61K31/472 , C07D217/04 , A61K31/4725 , A61P25/00 , A61P13/00 , A61P1/00 , A61P9/00 , C07D401/12
CPC分类号： C07D513/04 , C07D217/04 , C07D401/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US20080214603A1
公开(公告)日：2008-09-04
申请号：US11813080
申请日：2005-12-27
申请人： Antoni Torrens Jover , Susana Yenes Minguez , Josep Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut Henrich Buschmann
发明人： Antoni Torrens Jover , Susana Yenes Minguez , Josep Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut Henrich Buschmann
IPC分类号： A61K31/4725 , C07D401/06 , A61P25/00 , C07D401/14
CPC分类号： C07B57/00 , C07B2200/07 , C07B2200/11 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US08148397B2
公开(公告)日：2012-04-03
申请号：US11658923
申请日：2005-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Henrich Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Henrich Buschmann
IPC分类号： C07D217/18 , A61K31/47
CPC分类号： C07D513/04 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US20090264458A1
公开(公告)日：2009-10-22
申请号：US12471128
申请日：2009-05-22
申请人： Antoni Torrens Jover , Susana Yenes Minguez , Josep Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut Henrich Buschmann
发明人： Antoni Torrens Jover , Susana Yenes Minguez , Josep Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut Henrich Buschmann
IPC分类号： A61K31/473 , A61P25/00
CPC分类号： C07D221/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , Y10S514/914 , Y10S514/923
摘要： The invention relates to compounds having pharmacological activity towards the 5-receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-受体具有药理活性的化合物，更具体地涉及一些2,2a，4,5-四氢-1H-3-氮杂 - 苊烯取代的磺酰胺化合物，制备这些化合物的方法， 包含它们的组合物，以及它们用于治疗和/或预防其中涉及5-HT的疾病如CNS障碍的用途。
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公开(公告)号：US20090036480A1
公开(公告)日：2009-02-05
申请号：US11813069
申请日：2005-12-27
申请人： Antoni Torrens Jover , Susana Yenes Minguez , Josep Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut Henrich Buschmann
发明人： Antoni Torrens Jover , Susana Yenes Minguez , Josep Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut Henrich Buschmann
IPC分类号： A61K31/439 , C07D221/06 , A61P25/00 , A61P9/00 , A61P1/00
CPC分类号： C07D221/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , Y10S514/914 , Y10S514/923
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地涉及一些2,2a，4,5-四氢-1H-3-氮杂 - 苊烯取代的磺酰胺化合物，用于制备这些化合物的方法， 包含它们的药物组合物，以及它们用于治疗和/或预防其中涉及5-HT的疾病如CNS障碍的用途。
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公开(公告)号：US07211585B2
公开(公告)日：2007-05-01
申请号：US10920738
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D217/04 , C07D401/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US20060040978A1
公开(公告)日：2006-02-23
申请号：US10920738
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Buschmann
IPC分类号： C07D217/12 , A61K31/47 , C07D403/02 , A61K31/4709
CPC分类号： C07D217/04 , C07D401/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US07211584B2
公开(公告)日：2007-05-01
申请号：US10920671
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D401/12 , C07D217/04
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US20060040977A1
公开(公告)日：2006-02-23
申请号：US10920671
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut Buschmann
IPC分类号： C07D217/12 , A61K31/47
CPC分类号： C07D401/12 , C07D217/04
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。
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